Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tiziana Ginex"'
Autor:
Irene Molina-Panadero, Marcos Morales-Tenorio, Alfonso García-Rubia, Tiziana Ginex, Khalil Eskandari, Ana Martinez, Carmen Gil, Younes Smani
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our aim is to identify new small molecules with antimicrobial potential, especially against colistin-resistant (Col-R) Acinetobacter baumannii and Escherichia coli. After initial hits identification by fingerprint similarity, MIC of 24 heterocyclic d
Externí odkaz:
https://doaj.org/article/c5d65201a6bb4f93b0e75e543b8a7281
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Chemical libraries have become of utmost importance to boost drug discovery processes. It is widely accepted that the quality of a chemical library depends, among others, on its availability and chemical diversity which help in rising the chances of
Externí odkaz:
https://doaj.org/article/824044ccdabf497d9fbaf9fd1a8b4316
Autor:
Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P Mata, James Krieger, Paula Ruiz-Rodriguez, Maria Luisa López-Redondo, Clara Francés-Gómez, Roberto Melero, Carlos Óscar Sánchez-Sorzano, Marta Martínez, Nadine Gougeard, Alicia Forcada-Nadal, Sara Zamora-Caballero, Roberto Gozalbo-Rovira, Carla Sanz-Frasquet, Rocío Arranz, Jeronimo Bravo, Vicente Rubio, Alberto Marina, IBV-Covid19-Pipeline, Ron Geller, Iñaki Comas, Carmen Gil, Mireia Coscolla, Modesto Orozco, José Luis Llácer, Jose-Maria Carazo
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010995 (2022)
[This corrects the article DOI: 10.1371/journal.ppat.1010631.].
Externí odkaz:
https://doaj.org/article/ba2f6b5305b14bfdb18ac6c0d06dd810
Autor:
Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P Mata, James Krieger, Paula Ruiz-Rodriguez, Maria Luisa López-Redondo, Clara Francés-Gómez, Roberto Melero, Carlos Óscar Sánchez-Sorzano, Marta Martínez, Nadine Gougeard, Alicia Forcada-Nadal, Sara Zamora-Caballero, Roberto Gozalbo-Rovira, Carla Sanz-Frasquet, Rocío Arranz, Jeronimo Bravo, Vicente Rubio, Alberto Marina, IBV-Covid19-Pipeline, Ron Geller, Iñaki Comas, Carmen Gil, Mireia Coscolla, Modesto Orozco, José Luis Llácer, Jose-Maria Carazo
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010631 (2022)
The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific e
Externí odkaz:
https://doaj.org/article/2ac3186a08434f9d9f6e2286ac7350ff
Autor:
Dongwei Kang, Da Feng, Tiziana Ginex, Jinmi Zou, Fenju Wei, Tong Zhao, Boshi Huang, Yanying Sun, Samuel Desta, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 878-894 (2020)
In this report, a series of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives were designed to explore the hydrophobic channel of the non-nucleoside reverse transcriptase inhibitors binding pocket (NNIBP) by incorporating an aromati
Externí odkaz:
https://doaj.org/article/a73308a75e054803891d9922a9fb8b25
Autor:
Marc Aragó, Juan Moreno-Felici, Sonia Abás, Sergio Rodríguez-Arévalo, Petra Hyroššová, Agnes Figueras, Francesc Viñals, Belén Pérez, Maria I. Loza, Jose Brea, Pedro Latorre, Jose A. Carrodeguas, Pablo M. García-Rovés, Carlos Galdeano, Tiziana Ginex, Francisco J. Luque, Carmen Escolano, Jose C. Perales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 121, Iss , Pp 109601- (2020)
Background: Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. The mitochondrial isozyme, PEPCK-M is highly expressed in cancer cells, where it plays a role in nutrient stress response. To
Externí odkaz:
https://doaj.org/article/4129df432cec43aeb4c51f46efffb0d1
Autor:
Fatih Sonmez, Belma Zengin Kurt, Isil Gazioglu, Livia Basile, Aydan Dag, Valentina Cappello, Tiziana Ginex, Mustafa Kucukislamoglu, Salvatore Guccione
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 285-297 (2017)
New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-
Externí odkaz:
https://doaj.org/article/3acf90b3d3314526b2f00e68ec8bc1d9
Autor:
Tiziana Ginex, Urtzi Garaigorta, David Ramírez, Victoria Castro, Vanesa Nozal, Inés Maestro, Javier García-Cárceles, Nuria E. Campillo, Ana Martinez, Pablo Gastaminza, Carmen Gil
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 332 (2021)
The unprecedent situation generated by the COVID-19 global emergency has prompted us to actively work to fight against this pandemic by searching for repurposable agents among FDA approved drugs to shed light into immediate opportunities for the trea
Externí odkaz:
https://doaj.org/article/06dc279ce2ad4441b64f2dabf3ad9cba
Autor:
Sergio Rodríguez-Arévalo, Sònia Abás, Marc Aragó, Juan Moreno-Felici, Petra Hyroššová, Jose Carlos Perales, Carles Galdeano, Tiziana Ginex, Francisco Javier Luque, Carmen Escolano
Publikováno v:
Proceedings, Vol 22, Iss 1, p 95 (2019)
Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in gluconeogenesis, catalyzingthe decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
Externí odkaz:
https://doaj.org/article/ddc82735154c401190f258956eb2a5bd
Autor:
Francisco Javier Pérez-Areales, María Garrido, Ester Aso, Manuela Bartolini, Angela De Simone, Alba Espargaró, Tiziana Ginex, Raimon Sabate, Belén Pérez, Vincenza Andrisano, Francisco Javier Luque, Isidro Ferrer, Francisco Ciruela, Angel Messeguer, Diego Muñoz-Torrero
Publikováno v:
Proceedings, Vol 22, Iss 1, p 71 (2019)
Simultaneous modulation of several targets or pathological events with a key pathogenic role isa promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases [...]
Externí odkaz:
https://doaj.org/article/b1b387353b1a46559b0c75f36863a096