In vivo and in vitro metabolite profiling of nirmatrelvir using LC-Q-ToF-MS/MS along with the in silico approaches for prediction of metabolites and their toxicity.

Autor: Chaganti S; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Kushwah BS; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Velip L; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Tiwari SS; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Chilvery S; Department of Pharmacology, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Godugu C; Department of Pharmacology, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Samanthula G; Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.

Publikováno v: Biomedical chromatography : BMC [Biomed Chromatogr] 2024 May; Vol. 38 (5), pp. e5849. Date of Electronic Publication: 2024 Feb 25.

Establishment of antitick efficacy of a phytoformulation prepared from Annona squamosa leaf extracts for the management of acaricide resistant tick infestations on cattle.

Autor: Sharma AK; Entomology Laboratory, Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122 U.P. India., Tiwari SS; Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001 U.P., India., Kumar S; Entomology Laboratory, Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122 U.P. India., Rawat AKS; Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001 U.P., India., Srivastava S; Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001 U.P., India., Ray D; Entomology Laboratory, Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122 U.P. India., Singh NK; Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana 141004 Punjab India., Rawat SS; Department of Animals Husbandry, Govt. of Rajasthan, Chittorgarh 312001 Rajasthan, India., Sangwan AK; Department of Veterinary Parasitology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, 125004 Haryana, India., Ghosh S; Entomology Laboratory, Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122 U.P. India. Electronic address: sghoshtick@gmail.com.

Publikováno v: Acta tropica [Acta Trop] 2022 Sep; Vol. 233, pp. 106463. Date of Electronic Publication: 2022 Apr 20.

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

Autor: Jiwaji Z; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Tiwari SS; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Avilés-Reyes RX; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., Hooley M; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Hampton D; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Torvell M; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK.; UK Dementia Research Institute at Cardiff University, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Johnson DA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., McQueen J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Baxter P; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Sabari-Sankar K; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., Qiu J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., He X; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Fowler J; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Febery J; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Gregory J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Rose J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Tulloch J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Loan J; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Story D; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., McDade K; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK., Smith AM; UK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK., Greer P; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Ball M; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Kind PC; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Matthews PM; UK Dementia Research Institute at Imperial College, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK., Smith C; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK., Dando O; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Spires-Jones TL; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK., Johnson JA; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA. jeffrey.johnson@wisc.edu., Chandran S; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK. Siddharthan.Chandran@ed.ac.uk.; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK. Siddharthan.Chandran@ed.ac.uk., Hardingham GE; UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh, EH16 4SB, UK. Giles.Hardingham@ed.ac.uk.; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Giles.Hardingham@ed.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Jan 10; Vol. 13 (1), pp. 135. Date of Electronic Publication: 2022 Jan 10.

Elucidating the role of CYFIP2 in conferring cisplatin resistance in esophageal squamous cell carcinoma.

Autor: Zhang, Peipei¹ (AUTHOR), Zhang, Weiguang¹ (AUTHOR), Hong, Zhinuan¹ (AUTHOR), Jiang, Junfei¹ (AUTHOR), Wu, Ningzi¹ (AUTHOR), Lin, Jihong² (AUTHOR) ljh060@fjmu.edu.cn, Kang, Mingqiang^1,2,3,4 (AUTHOR) mingqiang_kang@163.com

Publikováno v: Scientific Reports. 11/7/2024, Vol. 14 Issue 1, p1-15. 15p.

Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing.

Autor: Ghosh A; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., Mizuno K; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., Tiwari SS; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., Gomez Perez-Nievas B; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., Glennon E; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., Martinez-Nunez RT; Department of Infectious Diseases, Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, 5th Floor Tower Wing, Guy's Campus, London, SE1 9RT, UK., Giese KP; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK. karl.giese@kcl.ac.uk.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2020 Jun 16; Vol. 10 (1), pp. 192. Date of Electronic Publication: 2020 Jun 16.