Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration.

Autor: Wisdom KM; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Suijker J; Mimetas B.V., Oegstgeest, The Netherlands., Van den Broek L; Mimetas B.V., Oegstgeest, The Netherlands., Sridharan B; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Grandhi TSP; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Cheng A; Genomic Sciences, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Lamb M; Genomic Sciences, Research, Pharmaceutical R&D, GSK, Stevenage, UK., Titus SA; Genomic Sciences, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Poore D; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Shah N; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Cheng SH; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Kim E; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA., Griffin S; Immuno-Oncology, Research, Pharmaceutical R&D, GSK, Stevenage, UK., Ekert J; In Vitro In Vivo Translation, Research, Pharmaceutical R&D, GSK, Collegeville, PA, USA.

Publikováno v: ALTEX [ALTEX] 2023; Vol. 40 (4), pp. 649-664. Date of Electronic Publication: 2023 Jun 16.

A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System.

Autor: Cheng E; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA., Dorjsuren D; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA., Lehman S; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA., Larson CL; Laboratory of Bacteriology, Coxiella Pathogenesis Section, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana, USA., Titus SA; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA., Sun H; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA., Zakharov A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA., Rai G; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA., Heinzen RA; Laboratory of Bacteriology, Coxiella Pathogenesis Section, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana, USA., Simeonov A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA., Machner MP; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Publikováno v: MBio [mBio] 2022 Apr 26; Vol. 13 (2), pp. e0024022. Date of Electronic Publication: 2022 Mar 08.

The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.

Autor: Caffall ZF; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Wilkes BJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA., Hernández-Martinez R; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Rittiner JE; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Fox JT; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Wan KK; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Shipman MK; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA., Titus SA; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Zhang YQ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Patnaik S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Boxer MB; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Li Z; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Vaillancourt DE; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.; Department of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA., Calakos N; Department of Neurology, Duke University Medical Center, Durham, NC 27715, USA. nicole.calakos@duke.edu.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27715, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC 27715, USA.; Duke Institute for Brain Sciences, Duke University, Durham, NC 27715, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Aug 18; Vol. 13 (607).

A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets.

Autor: Klanert G; Austrian Centre of Industrial Biotechnology, Graz, Austria.; University of Natural Resources and Life Sciences, Vienna, Austria., Fernandez DJ; Division of Preclinical Innovation, NCATS, NIH, Rockville, MD, USA., Weinguny M; Austrian Centre of Industrial Biotechnology, Graz, Austria.; University of Natural Resources and Life Sciences, Vienna, Austria., Eisenhut P; Austrian Centre of Industrial Biotechnology, Graz, Austria.; University of Natural Resources and Life Sciences, Vienna, Austria., Bühler E; Division of Preclinical Innovation, NCATS, NIH, Rockville, MD, USA., Melcher M; Austrian Centre of Industrial Biotechnology, Graz, Austria.; University of Natural Resources and Life Sciences, Vienna, Austria., Titus SA; Division of Preclinical Innovation, NCATS, NIH, Rockville, MD, USA., Diendorfer AB; Austrian Centre of Industrial Biotechnology, Graz, Austria., Gludovacz E; University of Natural Resources and Life Sciences, Vienna, Austria.; Medical University of Vienna, Vienna, Austria., Jadhav V; Austrian Centre of Industrial Biotechnology, Graz, Austria., Xiao S; Biotechnology Core Laboratory, NIDDK, NIH, Bethesda, MD, USA., Stern B; Department of Biomedicine, University of Bergen, Bergen, Norway.; UniTargetingResearch AS, Bergen, Norway., Lal M; Division of Preclinical Innovation, NCATS, NIH, Rockville, MD, USA. madhu.lal@nih.gov., Shiloach J; Biotechnology Core Laboratory, NIDDK, NIH, Bethesda, MD, USA. josephs@niddk.nih.gov., Borth N; Austrian Centre of Industrial Biotechnology, Graz, Austria. nicole.borth@boku.ac.at.; University of Natural Resources and Life Sciences, Vienna, Austria. nicole.borth@boku.ac.at.

Publikováno v: Scientific reports [Sci Rep] 2019 Jun 18; Vol. 9 (1), pp. 8689. Date of Electronic Publication: 2019 Jun 18.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Autor: Kearney SE; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zahoránszky-Kőhalmi G; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Brimacombe KR; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Henderson MJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lynch C; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zhao T; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Wan KK; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.; Department of Chemistry, Harvey Mudd College, 301 Platt Boulevard, Claremont, California 91711, United States., Itkin Z; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Dillon C; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Cheff DM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Bougie D; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Cheng K; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Coussens NP; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Dorjsuren D; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Eastman RT; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Huang R; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Iannotti MJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Karavadhi S; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Klumpp-Thomas C; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Roth JS; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Sakamuru S; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Sun W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Titus SA; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Yasgar A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zhang YQ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zhao J; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Andrade RB; Department of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania 19122, United States., Brown MK; Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States., Burns NZ; Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States., Cha JK; Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States., Mevers EE; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, United States., Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, United States., Clement JA; Natural Products Discovery Institute, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States., Crooks PA; University of Arkansas for Medical Sciences, 4301 West Markham Street 522, Little Rock, Arkansas 72205, United States., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 4849 Calhoun Road, Houston, Texas 77204, United States., Ganor J; Diamond Age Corp., 344 East Louisiana Street, McKinney, Texas 75069, United States., Moreno J; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Morrill LA; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Picazo E; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Susick RB; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Garg NK; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Goess BC; Department of Chemistry, Furman University, 3300 Poinsett Highway, Greenville, South Carolina 29613, United States., Grossman RB; Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States., Hughes CC; Scripps Institution of Oceanography, UCSD, 9500 Gilman Drive, La Jolla, California 92093, United States., Johnston JN; Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Nashville, Tennessee 37235, United States., Joullie MM; Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States., Kinghorn AD; College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, Ohio 43210, United States., Kingston DGI; Department of Chemistry, Virginia Tech, 900 West Campus Drive, Blacksburg, Virginia 24061, United States., Krische MJ; Chemistry Department, The University of Texas at Austin, 105 East 24th Street STOP A5300, Austin, Texas 78712, United States., Kwon O; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Maimone TJ; Department of Chemistry, University of California Berkeley, 826 Latimer Hall, Berkeley, California 94720, United States., Majumdar S; Department of Molecular Pharmacology and Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.; Center for Clinical Pharmacology, St Louis College of Pharmacy and Washington University School of Medicine, 2 Pharmacy Place, St. Louis, Missouri 63110, United States., Maloney KN; Department of Chemistry, Point Loma Nazarene University, 3900 Lomaland Drive, San Diego, California 92106, United States., Mohamed E; University of Mississippi School of Pharmacy, 2500 North State Street, Jackson, Mississippi 39216, United States., Murphy BT; College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607, United States., Nagorny P; Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States., Olson DE; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.; School of Medicine, Department of Biochemistry and Molecular Medicine, University of California, Davis, 2700 Stockton Boulevard, Suite 2102, Sacramento, California 95817, United States.; Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, California 95618, United States., Overman LE; Department of Chemistry, University of California, Irvine, Irvine, California 92697, United States., Brown LE; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States., Snyder JK; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States., Porco JA Jr; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States., Rivas F; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, United States., Ross SA; University of Mississippi School of Pharmacy, 2500 North State Street, Jackson, Mississippi 39216, United States., Sarpong R; Department of Chemistry, University of California Berkeley, 841-A Latimer Hall, Berkeley, California 94720, United States., Sharma I; Department of Chemistry and Biochemistry, and Institute of Natural Products and Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States., Shaw JT; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States., Xu Z; Department of Chemistry, Florida Campus, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States., Shen B; Department of Chemistry, Florida Campus, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States., Shi W; Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, United States., Stephenson CRJ; Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, United States., Verano AL; Pharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States., Tan DS; Pharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.; Chemical Biology Program, Sloan Kettering Institute and Tri-Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States., Tang Y; Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States., Taylor RE; Department of Chemistry and Biochemistry and the Warren Family Research Center for Drug Discovery and Development, University of Notre Dame, 305 McCourtney Hall, Notre Dame, Indiana 46556, United States., Thomson RJ; Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States., Vosburg DA; Department of Chemistry, Harvey Mudd College, 301 Platt Boulevard, Claremont, California 91711, United States., Wu J; Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States., Wuest WM; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.; Emory Antibiotic Resistance Center, Emory University School of Medicine, 201 Dowman Drive, Atlanta, Georgia 30322, United States., Zakarian A; Santa Barbara Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States., Zhang Y; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR., Ren T; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR., Zuo Z; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong SAR., Inglese J; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Michael S; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Shinn P; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Boxer MB; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Xia M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Guha R; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Rohde JM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

Publikováno v: ACS central science [ACS Cent Sci] 2018 Dec 26; Vol. 4 (12), pp. 1727-1741. Date of Electronic Publication: 2018 Dec 05.