Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Titus Kretzschmar"'
Autor:
Emese Szabo, Michael Weller, Abdijapar Shamshiev, Andrea Marti, Miriam Droste, Douglas J. Phillips, Titus Kretzschmar
Angiogenesis mediated by vascular endothelial growth factor (VEGF) is a hallmark of glioblastoma. Based on the response rate and improved progression-free survival, although not on overall survival, the 149-kDa anti-VEGF-A IgG antibody bevacizumab (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0d4e49f28a050a9dd597bfc9197f7c
https://doi.org/10.5167/uzh-153712
https://doi.org/10.5167/uzh-153712
Autor:
Emese Szabo, Douglas J. Phillips, Titus Kretzschmar, Julia Molitor, Japar Shamshiev, Michael Weller, Miriam Steinwand, Andrea Marti, Nicole Dreier, AnnaBianca Howald, Marco Landi, Camilla Winnewisser
Angiogenesis mediated by vascular endothelial growth factor (VEGF) is a hallmark of glioblastoma. Moreover, VEGF may exert tumor-intrinsic survival properties mediated both by VEGF receptors 1 and 2. Although various VEGF inhibitors have shown limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201371b2ef0b3c47d12060d3e0490b06
http://doc.rero.ch/record/292481/files/nov207.12.pdf
http://doc.rero.ch/record/292481/files/nov207.12.pdf
Publikováno v:
Expert Opinion on Drug Discovery. 2:1453-1465
The manipulation of eukaryotic cells by introducing nucleic acids and other substrates using chemical, physical or viral methods is one of the ground-breaking tools in the life sciences. Changes in the molecular equipment of a cell induced by introdu
Autor:
Titus Kretzschmar, Ralf Ostendorp, Bodo Brocks, Thomas von Rüden, Christian Frisch, Adolf Hoess
Publikováno v:
Journal of Immunological Methods. 275:203-212
We have developed a method for the high-level expression of expressed sequence tags (ESTs) as inclusion bodies in Escherichia coli by C-terminal fusion to the N1-domain of g3p of filamentous phage M13. Soluble fusion protein is obtained by an efficie
Autor:
Thomas von Rüden, Titus Kretzschmar
Publikováno v:
Current Opinion in Biotechnology. 13:598-602
Phage display has proven to be a robust and convenient technology for the selection of high-quality human antibodies from diverse libraries. Besides enabling the identification of antibodies in a fast, high-throughput mode, which allows comprehensive
Publikováno v:
Nucleic Acids Research. 26:697-702
Protein engineering by inserting stretches of random DNA sequences into target genes in combination with adequate screening or selection methods is a versatile technique to elucidate and improve protein functions. Established compounds for generating
Autor:
Otto Zingel, Bénédicte Vonach, Laurent Aoustin, Harry Towbin, Marcello Marangi, Titus Kretzschmar, Martin Geiser
Publikováno v:
Journal of Immunological Methods. 195:93-101
We have constructed a recombinant baculovirus encoding an anti-(phenyl-oxazolone) single-chain Fv antibody (anti-phOx-scFv) fused to the baculovirus GP67 secretion signal sequence. 6 liters of Sf9 insect cells were infected with this virus at a multi
Autor:
Andreas Klos, Dieter Bitter-Suermann, T. Stühmer, Monica Emde, Axel Kola, Titus Kretzschmar, Jörg Köhl, Wilfried Bautsch
Publikováno v:
Scopus-Elsevier
By site-directed mutagenesis of a human complement factor C5a cDNA clone, we have designed a hybrid anaphylatoxin in which three amino acid residues in the C-terminal sequence of human C5a were exchanged to create the native C-terminal human C3a (hC3
Autor:
Titus Kretzschmar, Derek Saunders, Andreas Klos, Michael Przewosny, Jörg Köhl, Wilfried Bautsch, Martina Pohl, Monika Casaretto
Publikováno v:
European Journal of Biochemistry. 210:185-191
Peptide compounds resembling the receptor-binding C-terminal domain of the anaphylatoxic peptide C3a were synthesized to examine two kinds of C3a antagonism: (a) specific desensitization of C3a-sensitive cells and (b) competitive binding to the C3a r
Autor:
Jörg Köhl, Wilfried Bautsch, Monica Emde, Dieter Bitter-Suermann, Detlev Suckau, Titus Kretzschmar
Publikováno v:
Immunobiology. 185:41-52
A gene coding for the human anaphylatoxin C5a was cloned and expressed in Escherichia coli. A combination of reverse transcription of mRNA of the U937 cell line with subsequent preparative polymerase chain reaction was employed to obtain the gene. Th