Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Titus J Boggon"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229627 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0226113.].
Externí odkaz:
https://doaj.org/article/6c04569ab7304da3b596e5f5b663217b
Autor:
Chad J Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S Fisher, Natasha L Pirman, Titus J Boggon, Jesse Rinehart, Michael B Yaffe, Rune Linding, Benjamin E Turk
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e2006540 (2019)
Specificity within protein kinase signaling cascades is determined by direct and indirect interactions between kinases and their substrates. While the impact of localization and recruitment on kinase-substrate targeting can be readily assessed, evalu
Externí odkaz:
https://doaj.org/article/4ebc7355466a4a8d843960e4922a2832
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226113 (2019)
The Rho and Ras pathways play vital roles in cell growth, division and motility. Cross-talk between the pathways amplifies their roles in cell proliferation and motility and its dysregulation is involved in disease pathogenesis. One important interac
Externí odkaz:
https://doaj.org/article/65d0f23a5c5c4372b3917893d3d467b9
Autor:
Joel A. Sexton, Tony Potchernikov, Jeffrey P. Bibeau, Gabriela Casanova-Sepúlveda, Wenxiang Cao, Hua Jane Lou, Titus J. Boggon, Enrique M. De La Cruz, Benjamin E. Turk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short, unstructured N-terminal region of cofilin is critical for actin binding and harbors the major sit
Externí odkaz:
https://doaj.org/article/0bf806576040487297309399396227f8
Autor:
Amy L Stiegler, Thomas D Grant, Joseph R Luft, David A Calderwood, Edward H Snell, Titus J Boggon
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55591 (2013)
The heterotrimeric protein complex containing the integrin linked kinase (ILK), parvin, and PINCH proteins, termed the IPP complex, is an essential component of focal adhesions, where it interacts with many proteins to mediate signaling from integrin
Externí odkaz:
https://doaj.org/article/6a1e5d283b594e66aeaa98d536348e31
Autor:
Jia Gao, Byung Hak Ha, Hua Jane Lou, Elizabeth M Morse, Rong Zhang, David A Calderwood, Benjamin E Turk, Titus J Boggon
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77818 (2013)
The p21-activated kinases (PAKs) are important effectors of Rho-family small GTPases. The PAK family consists of two groups, type I and type II, which have different modes of regulation and signaling. PAK6, a type II PAK, influences behavior and loco
Externí odkaz:
https://doaj.org/article/c3d0c0c6392e44dea8c849505f070ca7
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament severing, and are key nodes between Rho GTPase cascades and
Externí odkaz:
https://doaj.org/article/c3531119e69c4b7a96f2d5730a4cef1c
Autor:
Daniel B Costa, Balázs Halmos, Amit Kumar, Susan T Schumer, Mark S Huberman, Titus J Boggon, Daniel G Tenen, Susumu Kobayashi
Publikováno v:
PLoS Medicine, Vol 4, Iss 10, Pp 1669-79; discussion 1680 (2007)
Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib. These EGFR-dependent tumors eventually
Externí odkaz:
https://doaj.org/article/4fea8d1701474260a7245325bb964647
Autor:
Andrew T. Timberlake, Stephen McGee, Garrett Allington, Emre Kiziltug, Erin M. Wolfe, Amy L. Stiegler, Titus J. Boggon, May Sanyoura, Michelle Morrow, Tara L. Wenger, Erica M. Fernandes, Oana Caluseriu, John A. Persing, Sheng Chih Jin, Richard P. Lifton, Kristopher T. Kahle, Paul Kruszka
Publikováno v:
The American Journal of Human Genetics. 110:846-862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88afd7996bcebbdc97470493c1cea232
https://doi.org/10.1016/j.ajhg.2023.03.017
https://doi.org/10.1016/j.ajhg.2023.03.017
Autor:
Balázs Halmos, Daniel G. Tenen, Jeffrey A. Kern, Afshin Dowlati, Patrick C. Ma, Cheng Jin, Susumu Kobayashi, Titus J. Boggon, Zhiwei Yu
Supplementary Figure 2 from Resistance to an Irreversible Epidermal Growth Factor Receptor (EGFR) Inhibitor in EGFR-Mutant Lung Cancer Reveals Novel Treatment Strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18413f9ed303b411277e84386118179f
https://doi.org/10.1158/0008-5472.22370169.v1
https://doi.org/10.1158/0008-5472.22370169.v1
