Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tito Candelli"'
Autor:
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L. van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H. D. Kerstens, Lindy L. Visser, Maarten Rookmaaker, Marianne Verhaar, Godelieve A. M. Tytgat, Patrick Kemmeren, Ronald R. de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C. Rios, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Ruben van Boxtel, Frank C. P. Holstege, Hans Clevers, Jarno Drost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different
Externí odkaz:
https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d988
Publikováno v:
eLife, Vol 7 (2018)
RNA polymerase (RNAPII) transcription occurs pervasively, raising the important question of its functional impact on other DNA-associated processes, including replication. In budding yeast, replication originates from Autonomously Replicating Sequenc
Externí odkaz:
https://doaj.org/article/6ea0c7c5cba34868a1757bbe3c66d673
Publikováno v:
eLife, Vol 6 (2017)
In fission yeast, meiosis-specific transcripts are selectively eliminated during vegetative growth by the combined action of the YTH-family RNA-binding protein Mmi1 and the nuclear exosome. Upon nutritional starvation, the master regulator of meiosis
Externí odkaz:
https://doaj.org/article/5077cf4aae4542a1aadf53d1fe31f8b8
Autor:
Luke Jones, Ronald W. Stam, Pauline Schneider, Tito Candelli, Dedeke Rockx-Brouwer, Eduard Bodewes, Frank C. P. Holstege, P. Castro, Thanasis Margaritis, Rob Pieters
Publikováno v:
Leukemia
Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30–40%. The majority of patients initially show therapy response, but in two-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055657886cf10f39e341568437e46098
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Autor:
Vivian Morris, Dahai Wang, Zhiheng Li, William Marion, Travis Hughes, Patricia Sousa, Taku Harada, Shannan Ho Sui, Sergey Naumenko, Jérémie Kalfon, Prerana Sensharma, Marcelo Falchetti, Renan Vinicius da Silva, Tito Candelli, Pauline Schneider, Thanasis Margaritis, Frank C.P. Holstege, Yana Pikman, Marian Harris, Ronald W. Stam, Stuart H. Orkin, Angela N. Koehler, Alex K. Shalek, Trista E. North, Maxim Pimkin, George Q. Daley, Edroaldo Lummertz da Rocha, R. Grant Rowe
Publikováno v:
Cell Reports. 39:110752
High-risk forms of B-acute lymphoblastic leukemia (B-ALL) remain a therapeutic challenge. Leukemia-initiating cells (LICs) self-renew and spark relapse and therefore have been the subject of intensive investigation; however, the properties of LICs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a924113db672816a27cef43bd2f20799
https://doi.org/10.1016/j.celrep.2022.110752
https://doi.org/10.1016/j.celrep.2022.110752
Autor:
Thanasis Margaritis, P. Castro, Tito Candelli, Rob Pieters, Ronald W. Stam, Luke Jones, Frank C. P. Holstege, Pauline Schneider
Infants with MLL-rearranged acute lymphoblastic leukemia (ALL) undergo intense therapy to counter a highly aggressive leukemia with survival rates of only 30-40%. The majority of patients initially show therapy response, but in two-thirds of cases th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424454d7077f844ba1ef179ee68a4ff5
https://doi.org/10.1101/2020.04.14.20056580
https://doi.org/10.1101/2020.04.14.20056580
Autor:
Frank C. P. Holstege, Thanasis Margaritis, Jurrian K. de Kanter, Tito Candelli, Philip Lijnzaad
Publikováno v:
Nucleic Acids Research
Cell type identification is essential for single-cell RNA sequencing (scRNA-seq) studies, currently transforming the life sciences. CHETAH (CHaracterization of cEll Types Aided by Hierarchical classification) is an accurate cell type identification a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640c51b662345b8399f19bfe77ef2526
Autor:
Frank Feuerbach, Tito Candelli, David Shore, Mara Barucco, Drice Challal, Chaima Benaksas, Slawomir Kubik, Hélène Geoffroy, Domenico Libri
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2018, 72 (6), pp.955-969.e7. ⟨10.1016/j.molcel.2018.11.037⟩
Molecular Cell, 2018, 72 (6), pp.955-969.e7. ⟨10.1016/j.molcel.2018.11.037⟩
Molecular Cell, Elsevier, 2018, 72 (6), pp.955-969.e7. ⟨10.1016/j.molcel.2018.11.037⟩
Molecular Cell, 2018, 72 (6), pp.955-969.e7. ⟨10.1016/j.molcel.2018.11.037⟩
The fidelity of transcription initiation is essential for accurate gene expression, but the determinants of start site selection are not fully understood. Rap1 and other General Regulatory Factors (GRFs) control the expression of many genes in yeast.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda96180451db3a31d5250991233b9ed
https://hal.archives-ouvertes.fr/hal-02406559
https://hal.archives-ouvertes.fr/hal-02406559
Autor:
Thanasis Margaritis, Camilla Calandrini, Jarno Drost, Tito Candelli, Hans Clevers, Ruben van Boxtel, Marry M. van den Heuvel-Eibrink, Harry Begthel, Rurika Oka, Philip Lijnzaad, Marianne C. Verhaar, Frans Schutgens, Sepideh Derakhshan, Maarten Rookmaker, Ronald R. de Krijger, Kathy Pritchard-Jones, Luka Mathijsen, Frank C. P. Holstege, Anne C. Rios, Ravian L. van Ineveld, Hinri Kerstens, Lars Custers, Carola Ammerlaan, Patrick Kemmeren
Publikováno v:
Cancer Research. 80:IA27-IA27
Recent advances in in vitro culture technologies, such as adult stem cell-derived organoids, have opened up new avenues for the development of novel, more physiologic human cancer models. Such preclinical models are essential for efficient translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c8d958995099e6f693c6d283017c3c
https://doi.org/10.1158/1538-7445.pedca19-ia27
https://doi.org/10.1158/1538-7445.pedca19-ia27