Stepwise conformational stabilization of a hiv-1 clade c consensus envelope trimer immunogen impacts the profile of vaccine-induced antibody responses

Autor: Hauser, Alexandra, Carnell, George, Held, Kathrin, Sulbaran, Guidenn, Tischbierek, Nadine, Rogers, Lisa, Pollakis, Georgios, Tonks, Paul, Hoelscher, Michael, Ding, Song, Sanders, Rogier W., Geldmacher, Christof, Sattentau, Quentin, Weissenhorn, Winfried, Heeney, Jonathan L., Peterhoff, David, Wagner, Ralf

Publikováno v: Vaccines, 9(7):750. Multidisciplinary Digital Publishing Institute

Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn, will most likely be a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::06ea5f5f9baff9f18554dc5376f098fe
https://pure.amc.nl/en/publications/stepwise-conformational-stabilization-of-a-hiv1-clade-c-consensus-envelope-trimer-immunogen-impacts-the-profile-of-vaccineinduced-antibody-responses(e55d4831-1539-42ac-9ffa-f8bb7a1bb799).html

Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses

Autor: Wagner, Ralf, Hauser, Alexandra, Carnell, George, Held, Kathrin, Sulbaran, Guidenn, Tischbierek, Nadine, Rogers, Lisa, Pollakis, Georgios, Tonks, Paul, Hoelscher, Michael, Ding, Song, Sanders, Rogier W., Geldmacher, Christof, Sattentau, Quentin, Weissenhorn, Winfried, Heeney, Jonathan L., Peterhoff, David

Stabilization of the HIV-1 Envelope glycoprotein trimer (Env) in its native pre-fusion closed conformation is regarded as one of several requirements for the induction of neutralizing antibody (nAb) responses, which, in turn, will most likely be a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3175acaf0aa7caddef0b9f49718e6007

Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses.

Autor: Hauser A; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, 93053 Regensburg, Germany., Carnell G; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK., Held K; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802 Munich, Germany.; German Center for Infection Research (DZIF), Partner site Munich, 80802 Munich, Germany., Sulbaran G; Institut de Biologie Structurale (IBS), University Grenoble Alpes, CEA, CNRS, 38000 Grenoble, France., Tischbierek N; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, 93053 Regensburg, Germany., Rogers L; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802 Munich, Germany.; German Center for Infection Research (DZIF), Partner site Munich, 80802 Munich, Germany., Pollakis G; Department of Clinical Infection, Microbiology, and Immunology (CIMI), University of Liverpool, Liverpool L69 7BE, UK.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections (HPRU EZI), Liverpool L69 7BE, UK., Tonks P; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK., Hoelscher M; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802 Munich, Germany.; German Center for Infection Research (DZIF), Partner site Munich, 80802 Munich, Germany., Ding S; EuroVacc Foundation, 1105 BP Amsterdam, The Netherlands., Sanders RW; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA., Geldmacher C; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802 Munich, Germany.; German Center for Infection Research (DZIF), Partner site Munich, 80802 Munich, Germany., Sattentau Q; The Sir Willian Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, UK., Weissenhorn W; Institut de Biologie Structurale (IBS), University Grenoble Alpes, CEA, CNRS, 38000 Grenoble, France., Heeney JL; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK., Peterhoff D; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, 93053 Regensburg, Germany.; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany., Wagner R; Institute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), University of Regensburg, 93053 Regensburg, Germany.; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, Germany.

Publikováno v: Vaccines [Vaccines (Basel)] 2021 Jul 06; Vol. 9 (7). Date of Electronic Publication: 2021 Jul 06.