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Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.

Autor: Tirumuru Nagaraja, Li Chen, Anuradha Balasubramanian, Jerome E Groopman, Kalpana Ghoshal, Samson T Jacob, Andrew Leask, David R Brigstock, Appakkudal R Anand, Ramesh K Ganju

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46526 (2012)

BACKGROUND:The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the pathogenesis of hepatitis C virus (H

Externí odkaz: https://doaj.org/article/2c90ea8be2f44c04b8b614d69b5e4c8e

N ⁶ -Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production.

Autor: Lu W; From the Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210., Tirumuru N; From the Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210., St Gelais C; From the Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210., Koneru PC; the Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado 80045, and., Liu C; the Departments of Chemistry and of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and.; Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637., Kvaratskhelia M; the Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado 80045, and., He C; the Departments of Chemistry and of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and.; Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637., Wu L; From the Center for Retrovirus Research, Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, wu.840@osu.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Aug 24; Vol. 293 (34), pp. 12992-13005. Date of Electronic Publication: 2018 Jul 05.