Glyoxylate protects against cyanide toxicity through metabolic modulation.

Autor: Nielson JR; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, 84112, USA., Nath AK; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.; Broad Institute, Cambridge, MA, 02142, USA., Doane KP; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, 84112, USA., Shi X; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.; Broad Institute, Cambridge, MA, 02142, USA., Lee J; Beckman Laser Institute and Department of Medicine, University of California, Irvine, CA, 92697, USA., Tippetts EG; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, 84112, USA., Saha K; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Morningstar J; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.; Broad Institute, Cambridge, MA, 02142, USA., Hicks KG; Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, USA., Chan A; Department of Medicine, University of California, San Diego, CA, 92093, USA., Zhao Y; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Kelly A; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Hendry-Hofer TB; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Witeof A; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Sips PY; Department of Biomolecular Medicine, Ghent University, 9000, Ghent, Belgium., Mahon S; Beckman Laser Institute and Department of Medicine, University of California, Irvine, CA, 92697, USA., Bebarta VS; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Davisson VJ; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA., Boss GR; Department of Medicine, University of California, San Diego, CA, 92093, USA., Rutter J; Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, USA., MacRae CA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Brenner M; Beckman Laser Institute and Department of Medicine, University of California, Irvine, CA, 92697, USA., Gerszten RE; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.; Broad Institute, Cambridge, MA, 02142, USA., Peterson RT; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT, 84112, USA. randall.peterson@pharm.utah.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Mar 23; Vol. 12 (1), pp. 4982. Date of Electronic Publication: 2022 Mar 23.