Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Tiphaine Huet"'
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Akademický článek
A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects
Autor: Tiphaine Huet, Gilles Laverny, Fabrice Ciesielski, Ferdinand Molnár, Thanuja Gali Ramamoorthy, Anna Y. Belorusova, Pierre Antony, Noelle Potier, Daniel Metzger, Dino Moras, Natacha Rochel
Publikováno v: Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)
The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding dom
Externí odkaz: https://doaj.org/article/c1ca4632498449e98f431812cd05e383
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2
Akademický článek
Steroid receptor RNA activator (SRA) modification by the human pseudouridine synthase 1 (hPus1p): RNA binding, activity, and atomic model.
Autor: Tiphaine Huet, François-Alexandre Miannay, Jeffrey R Patton, Stéphane Thore
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94610 (2014)
The most abundant of the modified nucleosides, and once considered as the "fifth" nucleotide in RNA, is pseudouridine, which results from the action of pseudouridine synthases. Recently, the mammalian pseudouridine synthase 1 (hPus1p) has been report
Externí odkaz: https://doaj.org/article/b77fe52de2cf4b4cafd706ce10ca8ee1
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4
Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures
Autor: Vanessa, Delfosse, Tiphaine, Huet, Deborah, Harrus, Meritxell, Granell, Maxime, Bourguet, Caroline, Gardia-Parège, Barbara, Chiavarina, Marina, Grimaldi, Sébastien, Le Mével, Pauline, Blanc, David, Huang, Jakub, Gruszczyk, Barbara, Demeneix, Sarah, Cianférani, Jean-Baptiste, Fini, Patrick, Balaguer, William, Bourguet
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Many environmental pollutants act as endocrine disruptors that interfere with normal endocrine regulation and promote adverse effects in humans. As a major target of xenobiotics, the pregnane X receptor (PXR) is known to play opposite ro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68433fa00e8b9b0d20b25716c0e31102
https://pubmed.ncbi.nlm.nih.gov/33361153
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5
Akademický článek
The 'Phantom Effect' of the Rexinoid LG100754: structural and functional insights.
Autor: Yoshiteru Sato, Nick Ramalanjaona, Tiphaine Huet, Noelle Potier, Judit Osz, Pierre Antony, Carole Peluso-Iltis, Pierre Poussin-Courmontagne, Eric Ennifar, Yves Mély, Annick Dejaegere, Dino Moras, Natacha Rochel
Publikováno v: PLoS ONE, Vol 5, Iss 11, p e15119 (2010)
Retinoic acid receptors (RARs) and Retinoid X nuclear receptors (RXRs) are ligand-dependent transcriptional modulators that execute their biological action through the generation of functional heterodimers. RXR acts as an obligate dimer partner in ma
Externí odkaz: https://doaj.org/article/d2a19c9db72a4ebea9b6ac69ed9cb650
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7
A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects
Autor: Ferdinand Molnár, Noelle Potier, Fabrice Ciesielski, Pierre Antony, Gilles Laverny, Daniel Metzger, Anna Y. Belorusova, Thanuja Gali Ramamoorthy, Natacha Rochel, Dino Moras, Tiphaine Huet
Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2015, 10 (4), pp.516-526. ⟨10.1016/j.celrep.2014.12.045⟩
Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)
Summary The bioactive form of vitamin D [1,25(OH) 2 D 3 ] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59668a4739c2097bb989497f1a37d9ed
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8
Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction
Autor: Tiphaine Huet, Leonard M. G. Chavas, Nathalie Ferte, Charline J. J. Gerard, Romain Grossier, Nadine Candoni, Laurent Vuillard, Gilles Ferry, Stéphane Veesler, Jean A. Boutin
Publikováno v: Acta crystallographica Section F : Structural biology communications [2014-...]
Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩
Acta crystallographica. Section F, Structural biology communications
Acta crystallographica. Section F, Structural biology communications, John Wiley & Sons Ltd, 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩
Acta Crystallographica Section F Structural Biology Communications
A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b765580ecefb1a7518a375abfdd948
https://hal.science/hal-01493598v2/file/Charline_mF_RX_Acta_F_rev.pdf
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9
The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs
Autor: Adam Round, Tiphaine Huet, Stéphane Thore, Caroline Gabus, Margherita Tambalo, Fabiana Arieti
Publikováno v: Nucleic Acids Research
'Nucleic Acids Research ', vol: 42, pages: 6742-6752 (2014)
Nucleic Acids Research, Vol. 42, No 10 (2014) pp. 6742-6752
Nucleic acids research
The Split Ends (SPEN) protein was originally discovered in Drosophila in the late 1990s. Since then, homologous proteins have been identified in eukaryotic species ranging from plants to humans. Every family member contains three predicted RNA recogn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2ab62417aef3593bc58646523a4b6d
https://doi.org/10.1093/nar/gku277
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10
Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6): Chemical Synthesis of Catalytically Active Calstabin and Mutants
Autor: Leonard M. G. Chavas, Magali Jullian, Gilles Ferry, Mathias Antoine, Serena Sirigu, Lisa Bruyand, Olivier Nosjean, Karine Puget, Benjamin Fould, Tiphaine Huet, Laurent Vuillard, Luisa Ronga, Marine Bacchi, Jean A. Boutin
Publikováno v: Protein Science
Protein Science, Wiley, 2016, 25 (12), pp.2225-2242. ⟨10.1002/pro.3051⟩
International audience; Synthetic biology (or chemical biology) is a growing field to which the chemical synthesis of proteins, particularly enzymes, makes a fundamental contribution. However, the chemical synthesis of catalytically active proteins (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2975521da97be967543702c69f8c4f
https://hal.archives-ouvertes.fr/hal-01498750
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