Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Tip W. Loo"'
Autor:
Zsolt Bikadi, Istvan Hazai, David Malik, Katalin Jemnitz, Zsuzsa Veres, Peter Hari, Zhanglin Ni, Tip W Loo, David M Clarke, Eszter Hazai, Qingcheng Mao
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25815 (2011)
Human P-glycoprotein (P-gp) is an ATP-binding cassette multidrug transporter that confers resistance to a wide range of chemotherapeutic agents in cancer cells by active efflux of the drugs from cells. P-gp also plays a key role in limiting oral abso
Externí odkaz:
https://doaj.org/article/a19f57097012451dab15ef5acf742c53
Autor:
David M. Clarke, Tip W. Loo
Publikováno v:
Biochemical and Biophysical Research Communications. 488:573-577
P-glycoprotein (P-gp, ABCB1) is an ABC drug pump that is clinically important because it is involved in multidrug resistance. Many studies have used purified P-gp in detergent (n-dodecyl-β-D-maltoside; DM) micelles to map the locations of the drug-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259313812363b2e70e688a0ba3363d9a
https://doi.org/10.1016/j.bbrc.2017.05.106
https://doi.org/10.1016/j.bbrc.2017.05.106
Autor:
Tip W. Loo, David M. Clarke
Publikováno v:
Biochemical and Biophysical Research Communications. 472(2):379-383
P-glycoprotein (P-gp) is an ABC (ATP-Binding Cassette) drug pump. A common feature of ABC proteins is that they are organized into two wings. Each wing contains a transmembrane domain (TMD) and a nucleotide-binding domain (NBD). Drug substrates and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0217cd401da9644f4aa446e3ac4cdd4c
Autor:
David M. Clarke, Tip W. Loo
Publikováno v:
The Journal of Biological Chemistry
ABC (ATP-binding cassette) transporters are clinically important because drug pumps like P-glycoprotein (P-gp, ABCB1) confer multidrug resistance and mutant ABC proteins are responsible for many protein-folding diseases such as cystic fibrosis. Ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c98202b549a47b7b9a530ec3b562dfb
http://europepmc.org/articles/PMC4705942
http://europepmc.org/articles/PMC4705942
Autor:
David M. Clarke, Tip W. Loo
Publikováno v:
Biochemical pharmacology. 136
A large number of correctors have been identified that can partially repair defects in folding, stability and trafficking of CFTR processing mutants that cause cystic fibrosis (CF). The best corrector, VX-809 (Lumacaftor), has shown some promise when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9f5e131597b1356641ec949c9c6052
https://pubmed.ncbi.nlm.nih.gov/28366727
https://pubmed.ncbi.nlm.nih.gov/28366727
Autor:
David M. Clarke, Tip W. Loo
Publikováno v:
Journal of Biological Chemistry. 289:24749-24758
P-glycoprotein (P-gp) is an ATP-binding cassette drug pump that protects us from toxic compounds and confers multidrug resistance. The protein is organized into two halves. The halves contain a transmembrane domain (TMD) with six transmembrane segmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6b43cab9e34f9b8adc7ec931e93025
https://doi.org/10.1074/jbc.m114.583021
https://doi.org/10.1074/jbc.m114.583021
Autor:
Tip W. Loo, David M. Clarke
Publikováno v:
Journal of Biological Chemistry. 289:8484-8492
P-glycoprotein (P-gp, ABCB1) is an ATP-binding cassette drug pump that protects us from toxic compounds and confers multidrug resistance. Each homologous half contains a transmembrane domain with six transmembrane segments followed by a nucleotide-bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f25ac209c30c8da8c0cdc7f5d16bca
https://doi.org/10.1074/jbc.m114.552075
https://doi.org/10.1074/jbc.m114.552075
Autor:
David M. Clarke, Tip W. Loo
Publikováno v:
Biochemical Pharmacology. 88:46-57
Processing mutations that inhibit folding and trafficking of CFTR are the main cause of cystic fibrosis. Repair of CFTR mutants requires an understanding of the mechanisms of misfolding caused by processing mutations. Previous studies on helix-loop-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f33ebfac1f04b7f90a66aa8132e14eb
https://doi.org/10.1016/j.bcp.2013.12.027
https://doi.org/10.1016/j.bcp.2013.12.027
Publikováno v:
Biochemical Pharmacology. 86:612-619
Processing mutations that inhibit folding and trafficking of CFTR are the main cause of cystic fibrosis (CF). A potential CF therapy would be to repair CFTR processing mutants. It has been demonstrated that processing mutants of P-glycoprotein (P-gp)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b37f45129d757465e10718b26a5d8f
https://doi.org/10.1016/j.bcp.2013.06.028
https://doi.org/10.1016/j.bcp.2013.06.028
Publikováno v:
Journal of Biological Chemistry. 288:20326-20333
The P-glycoprotein drug pump protects us from toxins. Drug-binding sites in the transmembrane (TM) domains (TMDs) are connected to the nucleotide-binding domains (NBDs) by intracellular helices (IHs). TMD-NBD cross-talk is a key step in the transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f250a8af15213b5487c1f0ee8dbd4d42
https://doi.org/10.1074/jbc.m113.484550
https://doi.org/10.1074/jbc.m113.484550