Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tinyi Chu"'
Autor:
Anniina Vihervaara, Dig Bijay Mahat, Michael J. Guertin, Tinyi Chu, Charles G. Danko, John T. Lis, Lea Sistonen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Heat Shock Factor 1 (HSF1) is a regulator of stress-induced transcription. Here, the authors investigate changes to transcription and chromatin organization upon stress and find that activated HSF1 binds to transcription-primed promoters and enhancer
Externí odkaz:
https://doaj.org/article/8396af8fe6874b93839c2a87662af811
Publikováno v:
PeerJ, Vol 7, p e7008 (2019)
Quantitative trait locus (QTL) mapping has been used as a powerful tool for inferring the complexity of the genetic architecture that underlies phenotypic traits. This approach has shown its unique power to map the developmental genetic architecture
Externí odkaz:
https://doaj.org/article/d3cab0770e4a43c19d605ce4b164e8cc
Autor:
Sachi Horibata, Edward J Rice, Hui Zheng, Chinatsu Mukai, Tinyi Chu, Brooke A Marks, Scott A Coonrod, Charles G Danko
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194522 (2018)
Discovering regulatory interactions between genes that specify the behavioral properties of cells remains an important challenge. We used the dynamics of transcriptional changes resolved by PRO-seq to identify a regulatory network responsible for end
Externí odkaz:
https://doaj.org/article/18ccffbc827744b1b08c5ada6c81555e
Autor:
Ariella Glasner, Samuel A. Rose, Roshan Sharma, Herman Gudjonson, Tinyi Chu, Jesse A. Green, Sham Rampersaud, Izabella K. Valdez, Emma S. Andretta, Bahawar S. Dhillon, Michail Schizas, Stanislav Dikiy, Alejandra Mendoza, Wei Hu, Zhong-Min Wang, Ojasvi Chaudhary, Tianhao Xu, Linas Mazutis, Gabrielle Rizzuto, Alvaro Quintanal-Villalonga, Parvathy Manoj, Elisa de Stanchina, Charles M. Rudin, Dana Pe’er, Alexander Y. Rudensky
Publikováno v:
Nature Immunology. 24:1020-1035
While regulatory T (Treg) cells are traditionally viewed as professional suppressors of antigen presenting cells and effector T cells in both autoimmunity and cancer, recent findings of distinct Treg cell functions in tissue maintenance suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc13d7dbf662e5a5f892faf4c537973c
https://doi.org/10.1038/s41590-023-01504-2
https://doi.org/10.1038/s41590-023-01504-2
Publikováno v:
Nature Cancer. 3:505-517
Inferring single-cell compositions and their contributions to global gene expression changes from bulk RNA sequencing (RNA-seq) datasets is a major challenge in oncology. Here we develop Bayesian cell proportion reconstruction inferred using statisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e613eb6f260307c37ac1b671e33df8
https://doi.org/10.1038/s43018-022-00356-3
https://doi.org/10.1038/s43018-022-00356-3
Autor:
Rachel E. Niec, Tinyi Chu, Marina Schernthanner, Shiri Gur-Cohen, Lynette Hidalgo, Hilda Amalia Pasolli, Kathleen A. Luckett, Zhong Wang, Sohni R. Bhalla, Francesco Cambuli, Raghu P. Kataru, Karuna Ganesh, Babak J. Mehrara, Dana Pe’er, Elaine Fuchs
Publikováno v:
Cell Stem Cell
Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair. Epithelial stem cells of small and large intestines (ISCs) respond to their local microenvironments (niches) to fulfill a continuous demand for tissue turnover. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e9f5c4c09349aa499167391ff701f
https://europepmc.org/articles/PMC9271639/
https://europepmc.org/articles/PMC9271639/
Autor:
Zhong Wang, Alexandra G. Chivu, Lauren A. Choate, Edward J. Rice, Donald C. Miller, Tinyi Chu, Shao-Pei Chou, Nicole B. Kingsley, Jessica L. Petersen, Carrie J. Finno, Rebecca R. Bellone, Douglas F. Antczak, John T. Lis, Charles G. Danko
Publikováno v:
Nature genetics, vol 54, iss 3
The role of histone modifications in transcription remains incompletely understood. Here, we examine the relationship between histone modifications and transcription using experimental perturbations combined with sensitive machine-learning tools. Tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f45b8090fcc3bc4abaa84cc4e0f41a
https://escholarship.org/uc/item/3zw483c2
https://escholarship.org/uc/item/3zw483c2
Autor:
Richard Y.T. Kao, Tinyi Chu, Jacky Chi Ki Ngo, Sheila Li, Carmen O. K. Law, Liang Zhang, Jeffrey Kwan-Yiu Lau, Terrence Chi-Kong Lau, Xing Weng, Hoa Quynh Pham, Hoi-Kuan Kong, Kwok-Fai Lau, Rui Wang
Publikováno v:
Journal of Biological Chemistry. 294:372-378
The ribosomal maturation factor P (RimP) is a highly conserved protein in bacteria and has been shown to be important in ribosomal assembly in Escherichia coli. Because of its central importance in bacterial metabolism, RimP represents a good potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a428f8031b32b1e7f947a3c02b44df19
https://doi.org/10.1074/jbc.ra118.002298
https://doi.org/10.1074/jbc.ra118.002298
Autor:
Zhong, Wang, Alexandra G, Chivu, Lauren A, Choate, Edward J, Rice, Donald C, Miller, Tinyi, Chu, Shao-Pei, Chou, Nicole B, Kingsley, Jessica L, Petersen, Carrie J, Finno, Rebecca R, Bellone, Douglas F, Antczak, John T, Lis, Charles G, Danko
Publikováno v:
Nature genetics. 54(3)
The role of histone modifications in transcription remains incompletely understood. Here, we examine the relationship between histone modifications and transcription using experimental perturbations combined with sensitive machine-learning tools. Tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e156af18e49e5005c73fefcf142c92d4
https://pubmed.ncbi.nlm.nih.gov/35273400
https://pubmed.ncbi.nlm.nih.gov/35273400
Autor:
Tinyi Chu, Gregory T. Booth, H. Hans Salamanca, John T. Lis, Leighton J. Core, Robert John Corona, Charles G. Danko, Sharon L. Longo, Zhong Wang, Hojoong Kwak, Edward J. Rice, Lawrence S. Chin
Publikováno v:
Nature genetics
The human genome encodes a variety of poorly understood RNA species that remain challenging to identify using existing genomic tools. We developed chromatin run-on and sequencing (ChRO-seq) to map the location of RNA polymerase for almost any input s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f382d524229b11dc9834d8ca8fdcb9
http://europepmc.org/articles/PMC6204104
http://europepmc.org/articles/PMC6204104