Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tiny G. J. Meeuwsen-de Boer"'
Autor:
Inna Armandari, Walderik W. Zomerman, Sabine L. A. Plasschaert, Marlinde J. Smit, Tosca. E. I. Martini, Eduardo S. de Camargo Magalhães, Shanna M. Hogeling, Geesina C. Rozema-Huizinga, Harm J. Lourens, Tiny G. J. Meeuwsen-de Boer, Frank J. G. Scherpen, Eveline S. J. M. de Bont, Sophia W. M. Bruggeman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored. However, it is important to obtain a complete understanding of medulloblasto
Externí odkaz:
https://doaj.org/article/4b52aa87cc92410bae837f1ba12b32f3
Autor:
Irena Bočkaj, Tosca E. I. Martini, Eduardo S. de Camargo Magalhães, Petra L. Bakker, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, Saskia L. Meuleman, Marin T. Mondria, Colin Stok, Yannick P. Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J. C. Broekhuis, Hilda van den Bos, Diana C. J. Spierings, Femke C. A. Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A. T. M. van Vugt, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Externí odkaz:
https://doaj.org/article/f0f9f42a292e496a8dbe120dc4b20697
Autor:
Irena Bočkaj, Tosca E. I. Martini, Marlinde J. Smit, Inna Armandari, Bjorn Bakker, René Wardenaar, Tiny G. J. Meeuwsen-de Boer, Petra L. Bakker, Diana C. J. Spierings, Eelco W. Hoving, Victor Guryev, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9852 (2022)
Medulloblastoma is a pediatric brain malignancy that consists of four transcriptional subgroups. Structural and numerical aneuploidy are common in all subgroups, although they are particularly profound in Group 3 and Group 4 medulloblastoma and in a
Externí odkaz:
https://doaj.org/article/f73240404c5b403f963b1f47798fd400
Autor:
Walderik W. Zomerman, Sophia W.M. Bruggeman, Eduardo Sabino de Camargo Magalhães, Harm Jan Lourens, Frank J. G. Scherpen, Eveline S. J. M. de Bont, Tosca. E. I. Martini, Marlinde J. Smit, Shanna M. Hogeling, Tiny G. J. Meeuwsen-de Boer, Sabine L. A. Plasschaert, Geesina C. Rozema-Huizinga, Inna Armandari
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, 11(1):16077. Nature Publishing Group
Scientific Reports
Scientific Reports, 11(1):16077. Nature Publishing Group
While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored. However, it is important to obtain a complete understanding of medulloblastoma protei
Autor:
Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Autor:
Valerie de Haas, Eveline S. J. M. de Bont, Steven M. Kornblau, Victor Guryev, Kim R. Kampen, Hasan Mahmud, Tiny G. J. Meeuwsen-de Boer, Maikel M Peppelenbosch, Frank J. G. Scherpen, Arja ter Elst
Publikováno v:
Oncotarget, 10(45), 4679-4690. Impact Journals LLC
Scopus-Elsevier
Oncotarget
Scopus-Elsevier
Oncotarget
The majority of acute myeloid leukemia (AML) patients suffer from relapse and the exact etiology of AML remains unclear. The aim of this study was to gain comprehensive insights into the activity of signaling pathways in AML. In this study, using a h
Autor:
Marcel A. T. M. van Vugt, Pieter Wesseling, Wilfred F. A. den Dunnen, Frank A.E. Kruyt, Daniël O. Warmerdam, Sophia W.M. Bruggeman, Lisethe Meijer, Eveline S. J. M. de Bont, Esther Hulleman, Annika Seitz, Lorian Slagter-Menkema, Léon C van Kempen, Anke van den Berg, Walderik W. Zomerman, Tiny G. J. Meeuwsen-de Boer, Siobhan Conroy, Victor Guryev, Harm Jan Lourens, Frank J. G. Scherpen, Sergi Guerrero Llobet, Sabine L. A. Plasschaert, Floris Foijer, Marlinde J. Smit, Eelco W. Hoving, Corrie Gidding
Publikováno v:
Cell Reports
Cell Reports, 22(12), 3206-3216. Cell Press
Cell Reports, Vol 22, Iss 12, Pp 3206-3216 (2018)
Cell reports, 22(12), 3206-3216. CELL PRESS
Cell Reports, 22, 3206-3216
Neuro-Oncology, 20, 136-136. Oxford University Press
Zomerman, W W, Plasschaert, S L A, Conroy, S, Scherpen, F J, Meeuwsen-de Boer, T G J, Lourens, H J, Guerrero Llobet, S, Smit, M J, Slagter-Menkema, L, Seitz, A, Gidding, C E M, Hulleman, E, Wesseling, P, Meijer, L, van Kempen, L C, van den Berg, A, Warmerdam, D O, Kruyt, F A E, Foijer, F, van Vugt, M A T M, den Dunnen, W F A, Hoving, E W, Guryev, V, de Bont, E S J M & Bruggeman, S W M 2018, ' Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma ', Cell Reports, vol. 22, no. 12, pp. 3206-3216 . https://doi.org/10.1016/j.celrep.2018.02.089
Cell Reports, 22, 12, pp. 3206-3216
Cell Reports, 22(12), 3206-3216. Cell Press
Cell Reports, Vol 22, Iss 12, Pp 3206-3216 (2018)
Cell reports, 22(12), 3206-3216. CELL PRESS
Cell Reports, 22, 3206-3216
Neuro-Oncology, 20, 136-136. Oxford University Press
Zomerman, W W, Plasschaert, S L A, Conroy, S, Scherpen, F J, Meeuwsen-de Boer, T G J, Lourens, H J, Guerrero Llobet, S, Smit, M J, Slagter-Menkema, L, Seitz, A, Gidding, C E M, Hulleman, E, Wesseling, P, Meijer, L, van Kempen, L C, van den Berg, A, Warmerdam, D O, Kruyt, F A E, Foijer, F, van Vugt, M A T M, den Dunnen, W F A, Hoving, E W, Guryev, V, de Bont, E S J M & Bruggeman, S W M 2018, ' Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma ', Cell Reports, vol. 22, no. 12, pp. 3206-3216 . https://doi.org/10.1016/j.celrep.2018.02.089
Cell Reports, 22, 12, pp. 3206-3216
Summary: The brain cancer medulloblastoma consists of different transcriptional subgroups. To characterize medulloblastoma at the phosphoprotein-signaling level, we performed high-throughput peptide phosphorylation profiling on a large cohort of SHH
Autor:
Naomi E. van der Sligte, Arja ter Elst, Frank N. van Leeuwen, Tiny G. J. Meeuwsen-de Boer, Steven M. Kornblau, Eveline S. J. M. de Bont, Victor Guryev, Kim R. Kampen, Frank J. G. Scherpen
Publikováno v:
Oncotarget
Oncotarget, 6, 14970-81
Oncotarget, 6(17), 14970-14981. Impact Journals LLC
ResearcherID
Oncotarget, 6, 17, pp. 14970-81
Scopus-Elsevier
Oncotarget, 6, 14970-81
Oncotarget, 6(17), 14970-14981. Impact Journals LLC
ResearcherID
Oncotarget, 6, 17, pp. 14970-81
Scopus-Elsevier
Contains fulltext : 155199.pdf (Publisher’s version ) (Open Access) Acute lymphoblastic leukemia (ALL) relapse remains a leading cause of cancer related death in children, therefore, new therapeutic options are needed. Recently, we showed that a pe
Autor:
Eveline S. J. M. de Bont, Sander H. Diks, Frank N. van Leeuwen, Tiny G. J. Meeuwsen-de Boer, Maikel P. Peppelenbosch, Victor Guryev, Naomi E. van der Sligte, Harm Jan Lourens, Arja ter Elst, Frank J. G. Scherpen
Publikováno v:
Proteomics, 15, 1245-54
Proteomics, 15(7), 1245-1254. Wiley
Proteomics, 15, 7, pp. 1245-54
Proteomics, 15(7), 1245-1254. Wiley-VCH
Proteomics, 15(7), 1245-1254. Wiley
Proteomics, 15, 7, pp. 1245-54
Proteomics, 15(7), 1245-1254. Wiley-VCH
Item does not contain fulltext Still about 20% of patients with acute lymphoblastic leukemia (ALL) struggle with relapse, despite intensive chemotherapy. We and others have shown that kinase activity profiling is able to give more insights in active
Autor:
Wilfred F. A. den Dunnen, Irena Bockaj, Judith T.M.L. Paridaen, Victor Guryev, Eelco W. Hoving, Gerald de Haan, Zillah Siragna, Mirthe H. Schoots, Tosca. E. I. Martini, Tiny G. J. Meeuwsen-de Boer, Frank J. G. Scherpen, Marlinde J. Smit, Martha Ritsema, Sophia W.M. Bruggeman, Inna Armandari, Walderik W. Zomerman
Publikováno v:
Neuro-Oncology. 21:ii104-ii104
Sonic Hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) population that depends on Hedgehog signaling for its expansion. While SHH tumors are characterized by an overall deregulation of this pathway, they