Routine peri-operative cessation of glucagon-like peptide-1 receptor agonists has unintended consequences.

Autor: Levy NA; West Suffolk NHS Foundation Trust, Suffolk, UK., Tinsley SL; University Hospitals of North Midlands, Stoke-on-Trent, UK., Dhatariya K; Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.

Publikováno v: Anaesthesia [Anaesthesia] 2024 Dec 05. Date of Electronic Publication: 2024 Dec 05.

Unbiased discovery of cancer pathways and therapeutics using Pathway Ensemble Tool and Benchmark.

Autor: Wang L; Department of Computer Science, Purdue University, West Lafayette, IN, USA.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA., Pattnaik A; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Sahoo SS; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Stone EG; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Zhuang Y; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Benton A; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Tajmul M; Department of Biochemistry, Purdue University, West Lafayette, IN, USA.; Immunoregulation Section, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA., Chakravorty S; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Dhawan D; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA., Nguyen MA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Sirit I; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Mundy K; Department of Biomedical Engineering, Purdue University, West Lafayette, IN, USA., Ricketts CJ; Urologic Oncology Branch of Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA., Hadisurya M; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Baral G; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Tinsley SL; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Anderson NL; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Hoda S; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Briggs SD; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA., Kaimakliotis HZ; Department of Urology, School of medicine, Indiana University, Indianapolis, IN, USA., Allen-Petersen BL; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Tao WA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA.; Department of Chemistry, Purdue University, West Lafayette, IN, USA., Linehan WM; Urologic Oncology Branch of Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA., Knapp DW; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA., Hanna JA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Olson MR; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Afzali B; Immunoregulation Section, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA. ben.afzali@nih.gov., Kazemian M; Department of Computer Science, Purdue University, West Lafayette, IN, USA. kazemian@purdue.edu.; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA. kazemian@purdue.edu.; Department of Biochemistry, Purdue University, West Lafayette, IN, USA. kazemian@purdue.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 24; Vol. 15 (1), pp. 7288. Date of Electronic Publication: 2024 Aug 24.

PRMT5 Cooperates with pICln to Function as a Master Epigenetic Activator of DNA Double-Strand Break Repair Genes.

Autor: Owens JL; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA., Beketova E; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; Purdue University Interdisciplinary Life Sciences Graduate Program, Purdue University, West Lafayette, IN 47907, USA., Liu S; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA; The Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA., Tinsley SL; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; Purdue University Interdisciplinary Life Sciences Graduate Program, Purdue University, West Lafayette, IN 47907, USA., Asberry AM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; Purdue University Interdisciplinary Life Sciences Graduate Program, Purdue University, West Lafayette, IN 47907, USA., Deng X; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA., Huang J; Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA., Li C; Department of Medicinal Chemistry, University of Florida College of Pharmacy, Gainesville, FL 32610, USA., Wan J; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA; The Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA; The Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of BioHealth Informatics, Indiana University School of Informatics and Computing, Indiana University - Purdue University Indianapolis, Indianapolis, IN 46202, USA. Electronic address: junwan@iu.edu., Hu CD; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: hu1@purdue.edu.

Publikováno v: IScience [iScience] 2020 Jan 24; Vol. 23 (1), pp. 100750. Date of Electronic Publication: 2019 Nov 29.

Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.

Autor: Moody RR; From the Chemical Biology Program.; Department of Pharmaceutical Sciences, College of Pharmacy., Lo MC; Department of Pharmaceutical Sciences, College of Pharmacy, miaoclo@umich.edu., Meagher JL; Life Sciences Institute, and., Lin CC; Department of Pharmaceutical Sciences, College of Pharmacy., Stevers NO; Department of Pharmaceutical Sciences, College of Pharmacy., Tinsley SL; Department of Pharmaceutical Sciences, College of Pharmacy., Jung I; Department of Pharmaceutical Sciences, College of Pharmacy., Matvekas A; Department of Pharmaceutical Sciences, College of Pharmacy., Stuckey JA; Life Sciences Institute, and.; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109., Sun D; From the Chemical Biology Program, duxins@umich.edu.; Department of Pharmaceutical Sciences, College of Pharmacy.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Feb 09; Vol. 293 (6), pp. 2125-2136. Date of Electronic Publication: 2017 Dec 20.