Corrination mitigates peptide aggregation as exemplified for Glucagon.

Autor: Liles A; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States., Cham N; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States., Opp ML; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States., Tinsley IC; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States., Chepurny OG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States., Holz GG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States., Doyle RP; Department of Chemistry, Syracuse University, Syracuse, NY 13244, United States; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States; Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, United States. Electronic address: rpdoyle@syr.edu.

Publikováno v: Peptides [Peptides] 2024 Jan; Vol. 171, pp. 171134. Date of Electronic Publication: 2023 Dec 12.

Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects.

Autor: Asker M; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for molecular and translational medicine, University of Gothenburg, Gothenburg, Sweden., Krieger JP; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Liles A; Department of Chemistry, Syracuse University, Syracuse, New York, USA., Tinsley IC; Department of Chemistry, Syracuse University, Syracuse, New York, USA., Borner T; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Maric I; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Department of Chemistry, Syracuse University, Syracuse, New York, USA.; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA., Doebley S; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA., Furst CD; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA., Börchers S; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for molecular and translational medicine, University of Gothenburg, Gothenburg, Sweden., Longo F; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Bhat YR; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA., De Jonghe BC; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hayes MR; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Doyle RP; Department of Chemistry, Syracuse University, Syracuse, New York, USA.; Departments of Medicine and Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York, USA., Skibicka KP; Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for molecular and translational medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Mar; Vol. 25 (3), pp. 856-877. Date of Electronic Publication: 2023 Jan 09.

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4.

Autor: Tinsley IC; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Borner T; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States., Swanson ML; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Chepurny OG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States., Doebley SA; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States., Kamat V; Department of Medicine, University of Washington, Medicine Diabetes Institute, Seattle, Washington 98109, United States., Sweet IR; Department of Medicine, University of Washington, Medicine Diabetes Institute, Seattle, Washington 98109, United States., Holz GG; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States., Hayes MR; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States., De Jonghe BC; Department of Biobehavioral Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104, United States., Doyle RP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.; Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 3479-3492. Date of Electronic Publication: 2021 Mar 06.

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis.

Autor: Borner T; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA., Workinger JL; Department of Chemistry, Syracuse University, Syracuse, NY, USA., Tinsley IC; Department of Chemistry, Syracuse University, Syracuse, NY, USA., Fortin SM; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stein LM; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chepurny OG; Department of Medicine, Upstate Medical University, State University of New York, Syracuse, NY, USA., Holz GG; Department of Medicine, Upstate Medical University, State University of New York, Syracuse, NY, USA., Wierzba AJ; Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland., Gryko D; Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland., Nexø E; Department of Clinical Biochemistry and Clinical Medicine, University of Aarhus, Aarhus, Denmark., Shaulson ED; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA., Bamezai A; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Da Silva VAR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA., De Jonghe BC; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA., Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104, USA., Doyle RP; Department of Chemistry, Syracuse University, Syracuse, NY, USA; Department of Medicine, Upstate Medical University, State University of New York, Syracuse, NY, USA. Electronic address: rpdoyle@syr.edu.

Publikováno v: Cell reports [Cell Rep] 2020 Jun 16; Vol. 31 (11), pp. 107768.