Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tino W Sanchez"'
Autor:
Salma Khan, Jennifer Simpson, James C Lynch, David Turay, Saied Mirshahidi, Amber Gonda, Tino W Sanchez, Carlos A Casiano, Nathan R Wall
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0183122 (2017)
African-American men with prostate cancer typically develop more aggressive tumors than men from other racial/ethnic groups, resulting in a disproportionately high mortality from this malignancy. This study evaluated differences in the expression of
Externí odkaz:
https://doaj.org/article/e3c8c5f2f9064624b15ec8285156d8b7
Autor:
Allan I. Paxson, Loren H. Chang, Jaime M. C. Gard, William L. Harryman, Colin S. Nelson, Stella B. Salmon, Kendra D. Marr, Leah M. Wachsmuth, Anita Ramanathan, Jing Ran, Abhijeet Kapoor, Juan J. Marugan, Mark J. Henderson, Tino W. Sanchez, Anne E. Cress
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In 2023, approximately 288,300 new diagnoses of prostate cancer will occur, with 34,700 disease-related deaths. Death from prostate cancer is associated with metastasis, enabled by progression of tumor phenotypes and successful extracapsular extensio
Externí odkaz:
https://doaj.org/article/a456044366374dd1a817306440c69162
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Alpha-enolase, also known as enolase-1 (ENO1), is a glycolytic enzyme that “moonlights” as a plasminogen receptor in the cell surface, particularly in tumors, contributing to cancer cell proliferation, migration, invasion, and metastasis. ENO1 al
Externí odkaz:
https://doaj.org/article/7300ce534c0a425c8ccabc8c5d0688c4
Autor:
Ashley E. Owens, Michael J. Iannotti, Tino W. Sanchez, Ty Voss, Abhijeet Kapoor, Matthew D. Hall, Juan J. Marugan, Sam Michael, Noel Southall, Mark J. Henderson
Publikováno v:
ACS Chem Biol
Cellular thermal shift assay (CETSA) is a valuable method to confirm target engagement within a complex cellular environment, by detecting changes in a protein's thermal stability upon ligand binding. The classical CETSA method measures changes in th
Autor:
Tino W. Sanchez, Michael H. Ronzetti, Ashley E. Owens, Maria Antony, Ty Voss, Eric Wallgren, Daniel Talley, Krishna Balakrishnan, Ganesha Rai, Juan J. Marugan, Sam Michael, Bolormaa Baljinnyam, Noel Southall, Anton Simeonov, Mark J. Henderson
Determining a molecule’s mechanism of action is paramount during chemical probe development and drug discovery. The cellular thermal shift assay (CETSA) is a valuable tool to confirm target engagement in cells for a small molecule that demonstrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::583e055c50073797ad6dc130051773ba
https://doi.org/10.1101/2022.01.24.477382
https://doi.org/10.1101/2022.01.24.477382
Autor:
Mark J. Henderson, Eric Wallgren, Tino W. Sanchez, Natalia J. Martinez, Anton Simeonov, Ashley Owens
Publikováno v:
Targeted Protein Degradation ISBN: 9781071616642
Methods Mol Biol
Methods Mol Biol
The confirmation of a small molecule binding to a protein target can be challenging when switching from biochemical assays to physiologically relevant cellular models. The cellular thermal shift assay (CETSA) is an approach to validate ligand-protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3220f1476b6a2a13cb32a50a9cc4ee43
https://doi.org/10.1007/978-1-0716-1665-9_2
https://doi.org/10.1007/978-1-0716-1665-9_2
Autor:
Bo Li, Christine Molinaro, Denise L. Bellinger, Carlos A. Casiano, Tino W. Sanchez, Eugenia Mata-Greenwood
Publikováno v:
Am J Reprod Immunol
PROBLEM The Brown Norway (BN) rat is a model of T-helper 2 immune diseases, and also a model of pregnancy disorders that include placental insufficiency, fetal loss, and pre-eclampsia-like symptoms. The aim of this study was to investigate the plasma
Autor:
Catherine Elix, Chien-Shing Chen, Anamika Basu, Tino W. Sanchez, Ivana Alicea-Polanco, Leslimar Rios-Colon, Carlos A. Casiano, Vinodh Kumar Radhakrishnan, Christina K. Cajigas-Du Ross
Publikováno v:
Oncotarget
// Leslimar Rios-Colon 1 , Christina K. Cajigas-Du Ross 1 , Anamika Basu 1 , Catherine Elix 1 , Ivana Alicea-Polanco 1 , Tino W. Sanchez 1 , Vinodh Radhakrishnan 1 , Chien-Shing Chen 2 , Carlos A. Casiano 1, 3 1 Center for Health Disparities and Mole
Publikováno v:
The Prostate. 76:1375-1386
BACKGROUND The prostate-specific antigen (PSA) testing has been widely implemented for the early detection and management of prostate cancer (PCa). However, the lack of specificity has led to overdiagnosis, resulting in many possibly unnecessary biop
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 29:D117-D117
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the U.S., with African American (AA) men showing a higher mortality than European American (EA) men. While biological determinants contributing to PCa health disparities re