Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tino Klein"'
Autor:
Palle Serup, Carsten Gustavsen, Tino Klein, Leah A. Potter, Robert Lin, Nandita Mullapudi, Ewa Wandzioch, Angela Hines, Ashley Davis, Christine Bruun, Nina Engberg, Dorthe R. Petersen, Janny M. L. Peterslund, Raymond J. MacDonald, Anne Grapin-Botton, Mark A. Magnuson, Kenneth S. Zaret
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 956-966 (2012)
SUMMARY Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals a
Externí odkaz:
https://doaj.org/article/63f5b0186d674ef187de317844c569e5
Autor:
Peter Brøgger, Lars Aagaard, H. D. Pedersen, Peter Bross, Sif Groth Rønn, Tino Klein, Charlotte Brandt Sørensen, Trine Skov Petersen, Rasha Abdelkadhem Al-Saaidi, Yan Zhou, Dianna Hussmann, Yonglun Luo, Yong Liu, Anders Lade Nielsen, Guangqian Zhou, Lin Lin, Shuang Tan, Lars Bolund
Publikováno v:
Zhou, Y, Liu, Y, Hussmann, D, Brøgger, P, Al-Saaidi, R A, Tan, S, Lin, L, Petersen, T S, Zhou, G Q, Bross, P, Aagaard, L, Klein, T, Rønn, S G, Pedersen, H D, Bolund, L, Nielsen, A L, Sørensen, C B & Luo, Y 2016, ' Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system ', Cellular and Molecular Life Sciences, vol. 73, no. 13, pp. 2543-63 . https://doi.org/10.1007/s00018-015-2128-3
Programmable DNA nucleases such as TALENs and CRISPR/Cas9 are emerging as powerful tools for genome editing. Dual-fluorescent surrogate systems have been demonstrated by several studies to recapitulate DNA nuclease activity and enrich for genetically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40220a9109b2dfd8d54bcffbf05a291
https://pure.au.dk/portal/da/publications/enhanced-genome-editing-in-mammalian-cells-with-a-modified-dualfluorescent-surrogate-system(44e6d9fd-64a1-4f25-a66e-cff3c3f69c3b).html
https://pure.au.dk/portal/da/publications/enhanced-genome-editing-in-mammalian-cells-with-a-modified-dualfluorescent-surrogate-system(44e6d9fd-64a1-4f25-a66e-cff3c3f69c3b).html
Autor:
Signe Horn, Tino Klein, Mette C. Jørgensen, Jonas Ahnfelt-Rønne, Young-Yun Kong, Mark A. Magnuson, Heiko Lickert, Jill Lindner, Jan N. Jensen, Moritz Gegg, Sune Kobberup, Palle Serup, Ryoichiro Kageyama, Mark Kalisz
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 109, 7356-7361 (2012)
During early pancreatic development, Notch signaling represses differentiation of endocrine cells and promotes proliferation of Nkx6-1 + Ptf1a + multipotent progenitor cells (MPCs). Later, antagonistic interactions between Nkx6 transcription factors
Publikováno v:
Gene Expression Patterns. 12:85-93
The cis-acting elements that regulate Eomes transcription during embryonic development are largely unknown. Here we identify a conserved cis-acting region (EoIV) located ~20kb upstream of the Eomes coding region that faithfully drives reporter expres
Autor:
Stoyan G. Petkov, Hendrik Marks, Tino Klein, Rodrigo S. Garcia, Poul Hyttel, Henk Stunnenberg, Yu Gao
Publikováno v:
Stem Cell Research
Stem Cell Research; Vol 6
Stem Cell Research, 6, 226-237
Stem Cell Research, 6, 3, pp. 226-237
Stem Cell Research; Vol 6
Stem Cell Research, 6, 226-237
Stem Cell Research, 6, 3, pp. 226-237
Embryonic germ cells (EGC) are cultured pluripotent cells derived from primordial germ cells (PGC). This study explored the possibility of establishing porcine EGC from domestic breeds and Yucatan mini pigs using embryos at Days 17-24 of gestation. I
Publikováno v:
Vrije Universiteit Brussel
In this study we examined the expression of nestin in islets, the exocrine part, and the big ducts of the adult human pancreas by immunofluorescent double staining. Two different anti-nestin antisera in combination with various pancreatic and endothe
Publikováno v:
Vrije Universiteit Brussel
Writs arc important signaling molecules involved in many normal developmental processes in the human body as well as some forms of cancer. Nineteen Wnt genes arc found in the human genome, as well as 10 Wnt receptor genes called Frizzled. Two corecep
Publikováno v:
Archives of Biochemistry and Biophysics. 395:259-263
It is currently believed that pancreatic progenitor or stem cells exist in the ductal cell population and that these cells have the ability to be grown and differentiated into endocrine cells for the treatment of diabetes. In this study, we have exam
Publikováno v:
European Journal of Biochemistry. 267:1008-1018
The three-dimensional solution structure of the protein part of Cu7 metallothionein (Cu7MT) of Saccharomyces cerevisiae has been attempted by 1H two-dimensional NMR spectroscopy at 800 MHz. The protein part constitutes 53 amino acids. A total of 1192
Autor:
Sonja-Verena Albers, Hans Peter Arnold, Jan Hiort, Tino Klein, David Prangishvili, Wolfram Zillig, Anja Schweier, Jakob K. Kristjansson, Harpreet Singh, Ingelore Holz, Kenneth M. Stedman
Publikováno v:
Plasmid. 40:190-202
We describe five novel conjugative plasmids (CPs) and two subfamilies, each comprising several closely related variants of CPs isolated from colony-cloned strains of the extremely thermophilic, heterotrophic archaeon Sulfolobus islandicus, which were