Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tino Heimburg"'
Autor:
Hugo Rolando Vaca, Ana María Celentano, María Agustina Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Oliveira, María Celina Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009226 (2021)
BackgroundEchinococcosis and cysticercosis are neglected tropical diseases caused by cestode parasites (family Taeniidae). Not only there is a small number of approved anthelmintics for the treatment of these cestodiases, but also some of them are no
Externí odkaz:
https://doaj.org/article/4e0617f643d64ddcac83ccd16c054427
Autor:
Salma Darwish, Tino Heimburg, Johannes Ridinger, Daniel Herp, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4559db7af55f1dd1ef423c05112f67b
https://doi.org/10.1007/978-1-0716-2788-4_12
https://doi.org/10.1007/978-1-0716-2788-4_12
Autor:
Salma, Darwish, Tino, Heimburg, Johannes, Ridinger, Daniel, Herp, Matthias, Schmidt, Christophe, Romier, Manfred, Jung, Ina, Oehme, Wolfgang, Sippl
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2589
Histone deacetylases are considered promising epigenetic targets for chemical protein degradation due to their diverse roles in physiological cellular functions and in the diseased state. Proteolysis-targeting chimeras (PROTACs) are bifunctional mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfe001de6a122f48974a927d57baf115
https://pubmed.ncbi.nlm.nih.gov/36255625
https://pubmed.ncbi.nlm.nih.gov/36255625
Autor:
Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Johannes Ridinger, Karin Schmidtkunz, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
While histone deacetylases (HDACs) are known as modulators of epigenetic gene regulation, they also control the activity of non-histone protein substrates. The isozyme HDAC8 plays a role in inhibiting apoptosis and increasing cancer cell proliferatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b597d966a7daac3125736d75f535dd
https://doi.org/10.26434/chemrxiv-2022-blb5v
https://doi.org/10.26434/chemrxiv-2022-blb5v
Autor:
Wolfgang Sippl, Tino Heimburg, Simon Nadal, Polina Prokofeva, Ludwig Lautenbacher, Michael W. Pfaffl, Maurine E. Linder, Carmen Stumpf, Christina Loos, Chen Meng, Xin Ku, Christian Grätz, Agnes Baron, Vivian Würf, Severin Lechner, Mathias Wilhelm, Bernhard Kuster, Karin Kleigrewe, Karl J. Kramer, Martin Ian P. Malgapo, Josch Konstantin Pauling, Patrick Leopold Rüther, Guillaume Médard
HDAC drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a chemical proteomics assay using three promiscuous chemotypes and quantitative mass spectrometry that we dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::517663c2d59a2fc20032ea9acb0153ce
https://doi.org/10.21203/rs.3.rs-646613/v1
https://doi.org/10.21203/rs.3.rs-646613/v1
Publikováno v:
Epigenetic Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef031bd3b8fc2474830960971cc9a2d
https://doi.org/10.1002/9783527809257.ch3
https://doi.org/10.1002/9783527809257.ch3
Autor:
Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, Raphael R. Steimbach, Agnes Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Kuster, Guillaume Médard
Publikováno v:
Nature Chemical Biology. 18:913-913
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7a11bf5cbf9f98e56d57ead7e4842b9
https://doi.org/10.1038/s41589-022-01112-5
https://doi.org/10.1038/s41589-022-01112-5
Autor:
Nikolas Gunkel, Manfred Jung, Tino Heimburg, Fiona R. Kolbinger, E Koeneke, Frank Westermann, Johannes Ridinger, Michael W. Müller, Theresa Bayer, Ina Oehme, Wolfgang Sippl, Aubry K. Miller, Olaf Witt
Publikováno v:
Archives of Toxicology
High histone deacetylase (HDAC) 8 and HDAC10 expression levels have been identified as predictors of exceptionally poor outcomes in neuroblastoma, the most common extracranial solid tumor in childhood. HDAC8 inhibition synergizes with retinoic acid t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2224347a7fc89bf54ace597034f75773
https://doi.org/10.1007/s00204-018-2234-8
https://doi.org/10.1007/s00204-018-2234-8
Autor:
E Koeneke, Olaf Witt, Sara Najafi, Frank Westermann, Benjamin Meder, Manfred Jung, Fiona R. Kolbinger, Martin Distel, Johannes Fabian, Ina Oehme, Sina Stäble, Dominique Kranz, Tino Heimburg, Heike Peterziel, Wolfgang Sippl, Jagoda K. Wrobel, Michael Boutros, Jing Shen
Publikováno v:
Cell Death and Differentiation
The prognosis of advanced stage neuroblastoma patients remains poor and, despite intensive therapy, the 5-year survival rate remains less than 50%. We previously identified histone deacetylase (HDAC) 8 as an indicator of poor clinical outcome and a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e1c15279863d8f2560b093c6833de6
https://doi.org/10.1038/s41418-018-0080-0
https://doi.org/10.1038/s41418-018-0080-0
Autor:
Raymond J. Pierce, Sophie Salomé-Desnoulez, Katia Cailliau, Wolfgang Sippl, Stéphanie Caby, Jean-Michel Saliou, Thierry Chassat, Julien Lancelot, Lucile Pagliazzo, Jérôme Vicogne, Tino Heimburg
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2021, 15 (11), pp.e0009503. ⟨10.1371/journal.pntd.0009503⟩
PLoS Neglected Tropical Diseases, Public Library of Science, 2021, 15 (11), pp.e0009503. ⟨10.1371/journal.pntd.0009503⟩
PLoS Neglected Tropical Diseases, 2021, 15 (11), pp.e0009503. ⟨10.1371/journal.pntd.0009503⟩
PLoS Neglected Tropical Diseases, Public Library of Science, 2021, 15 (11), pp.e0009503. ⟨10.1371/journal.pntd.0009503⟩
Background Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has elicited considerable interest as a target for drug discovery. Invalidation of its transcripts by RNAi leads to impaired survival of the worms in infected mice and its inhibition caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ee57789c9a99f38cc6cf32931b8c55
https://doi.org/10.1371/journal.pntd.0009503
https://doi.org/10.1371/journal.pntd.0009503