Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tinne Verhulst"'
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
A) Structure of JNJ-42541707, a structurally related compound to JNJ-42756493. B) 72h growth inhibition (IC50) of JNJ-42541707 against 236 cancer cell lines from multiple origins color coded based on FGFR1,2,4 mRNA overexpression and FGFR WT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014876daf0ea3141cec8e46d4cd3afe8
https://doi.org/10.1158/1535-7163.22503741
https://doi.org/10.1158/1535-7163.22503741
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
In vitro kinase inhibition by DiscoverX KinomeScan assay. For details see (19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707b5abacc5ec387fe47990836d03d73
https://doi.org/10.1158/1535-7163.22503738
https://doi.org/10.1158/1535-7163.22503738
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
Inhibitory activity of Brivanib and JNJ-42756943 in kinase (top) and BaF3 kinase dependent proliferation (bottom) assays and ratio of FGFRs/VEGFR2 activities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60399ae060b7382e0f81605f3d51fc78
https://doi.org/10.1158/1535-7163.22503735
https://doi.org/10.1158/1535-7163.22503735
Autor:
Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
JNJ-42756493 anti-proliferative activity against cancer cells lines from multiple origins.. Detailed data supporting Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bca756040d98715cf3d679230a312d
https://doi.org/10.1158/1535-7163.22503732.v1
https://doi.org/10.1158/1535-7163.22503732.v1
Autor:
Jorge Vialard, Timothy Perera, Tinne Verhulst, Elena Maria Tosca, Paolo Magni, Nadia Terranova, Peter King, Anne-Gaëlle Dosne, Kim Stuyckens, Juan Jose Perez-Ruixo, Italo Poggesi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:117-128
Erdafitinib (JNJ-42756493, BALVERSA) is a tyrosine kinase inhibitor indicated for the treatment of advanced urothelial carcinoma. In this work, a translational model-based approach to inform the choice of the doses in phase 1 trials is illustrated. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca80545d962515567feae8c83d1b1b1
https://doi.org/10.1007/s00280-021-04370-7
https://doi.org/10.1007/s00280-021-04370-7
Autor:
Min Chul Kwon, Olivier Querolle, Xuedong Dai, Jan Willem Thuring, Tinne Verhulst, Ann Marien, Dries Goffin, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Karin Verstraeten, Sara El Ashkar, Shanna M Hogeling, Frank Jacob, Petra Vinken, Nicolas Darville, Vineet Pande, Daniel Krosky, Gregor Urbanietz, Bie Verbist, Lucille A. Ferrante, Christina Diane Drenberg, David Wilson, Ricardo M. Attar, Jan Jacob Schuringa, Nikki Daskalakis, Kathryn Packman, Christine Pietsch, Yusri Elsayed, Ulrike Philippar
Publikováno v:
Blood. 140:5928-5929
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc637fd2b48b32c40a713ec792434dbb
https://doi.org/10.1182/blood-2022-168921
https://doi.org/10.1182/blood-2022-168921
Autor:
Tinne Verhulst, Lieven Meerpoel, Emmanuel Gustin, Weimei Sun, Matthew V. Lorenzi, Junchen Gu, Longen Zhou, Wim Bert Griet Schepens, Hillary Millar, Tongfei Wu, Viellevoye Marcel, Vineet Pande, Petra Vinken, Desiree De Lange, An Boeckx, Christopher Moy, Friederike Pastore, Geert Mannens, Sylvie Laquerre, Ulrike Philippar, Vipul Bhargava, Gaston Stanislas Marcella Diels, Thomas Nys, Kathryn Packman, Jan Willem Thuring, Erika van Heerde, Bie Verbist, Sumit Rai, Lijs Beke, Pegah Safabakhsh, Timothy A. Graubert, Yue Fan, Angelique N Gilbert, Dirk Brehmer, Vikki Keersmaekers, Barbara Morschhäuser, Danilo Fiore, David Walker, Amy J. Johnson
Publikováno v:
Molecular cancer therapeutics. 20(12)
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bff6d3af11d308608e3ab20a3144c14
https://pubmed.ncbi.nlm.nih.gov/34583982
https://pubmed.ncbi.nlm.nih.gov/34583982
Autor:
Peter King, Suso Platero, Matthew V. Lorenzi, Kelly Van De Ven, Caroline Paulussen, Liang Xie, Jennifer Yang, Jorge Vialard, Christopher Moy, Eleonora Jovcheva, Timothy Perera, David R. Newell, Jayaprakash Karkera, Sylvie Laquerre, Martin Page, Ron Gilissen, David C. Rees, Neil T. Thompson, George Ward, Desiree De Lange, Laurence Anne Mevellec, Patrick Angibaud, Matthew S Squires, Tinne Verhulst, Na Cheng, Eddy Jean Edgard Freyne, Christopher William Murray, Gordon Saxty
Publikováno v:
Molecular Cancer Therapeutics. 16:1010-1020
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links to several hallmarks of cancer. Genetic alterations in FGF receptor (FGFR) family members are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4415ac185c23833df1086dc6f666f7
https://doi.org/10.1158/1535-7163.mct-16-0589
https://doi.org/10.1158/1535-7163.mct-16-0589
Autor:
Dushen Chetty, Matthew V. Lorenzi, Sylvie Laquerre, Gaston Stanislas Marcella Diels, Edward C. Lawson, Carol Yanovich, Italo Poggesi, Ivan Somers, Dana Gaffney, Wim Bert Griet Schepens, Hillary Millar, Weimei Sun, Tongfei Wu, Lijs Beke, Viellevoye Marcel, Marc Du Jardin, Petra Vinken, Erika van Heerde, Tinne Verhulst, James P. Edwards, Dirk Brehmer, Barbara Herkert, Geert Mannens, Vineet Pande, Alain Philippe Poncelet, Christopher Moy, An Boeckx, Marc Parade, Thomas Nys, Jan-Willem Thuring, Lieven Meerpoel, Joannes T. M. Linders
Publikováno v:
Cancer Research. 77:DDT02-04
PRMT5 is a type II methyltransferase that specifically adds methyl groups to arginine as a long-lasting post-translational modification. The PRMT5/MEP50 complex regulates a plethora of cellular processes, such as epigenetics and splicing, which are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987bd807a6c9b8052bd2995cb8ff5795
https://doi.org/10.1158/1538-7445.am2017-ddt02-04
https://doi.org/10.1158/1538-7445.am2017-ddt02-04
Autor:
Tinne Verhulst, Tongfei Wu, An Boeckx, Nahor Haddish-Berhane, Erika van Heerde, Joseph Portale, Dirk Brehmer, Tony Greway, Kathryn Packman, Hillary Millar, Dana Gaffney, Sylvie Laquerre, Thomas Nys, Ulrike Philippar
Publikováno v:
Cancer Research. 79:950-950
Protein arginine methyltransferase 5 (PRMT5), a type II methyltransferase, is responsible for symmetric arginine di-methylation of multiple cellular proteins involved in the regulation of cellular transcription. PRMT5 is involved in cellular processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b3d4ec4e7e41833e3a1b01ba499f744
https://doi.org/10.1158/1538-7445.am2019-950
https://doi.org/10.1158/1538-7445.am2019-950