Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Tingxi Guo"'
Autor:
Kenji Murata, Munehide Nakatsugawa, Muhammed A Rahman, Linh T Nguyen, Douglas G Millar, David T Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Brian D Burt, Dalam Ly, Kayoko Saso, Alexandra Easson, David P Goldstein, Michael Reedijk, Danny Ghazarian, Trevor J Pugh, Marcus O Butler, Tak W Mak, Pamela S Ohashi, Naoto Hirano
Publikováno v:
eLife, Vol 9 (2020)
HLA-restricted T cell responses can induce antitumor effects in cancer patients. Previous human T cell research has largely focused on the few HLA alleles prevalent in a subset of ethnic groups. Here, using a panel of newly developed peptide-exchange
Externí odkaz:
https://doaj.org/article/d455cc6e68c4440b81ba240acbcb367a
Autor:
Yuki Kagoya, Munehide Nakatsugawa, Kayoko Saso, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Marcus O. Butler, Cheryl H. Arrowsmith, Naoto Hirano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Adoptive T cell therapy using an allogeneic T cell graft is an encouraging therapeutic approach in cancer, but issues such as graft-versus-host disease can hinder applicability. Here, the authors show that DOT1L inhibition or DUSP6 overexpression in
Externí odkaz:
https://doaj.org/article/d6ce55cb15b249f6b173e89e668c2976
Autor:
Yuki Yamashita, Mark Anczurowski, Munehide Nakatsugawa, Makito Tanaka, Yuki Kagoya, Ankit Sinha, Kenji Chamoto, Toshiki Ochi, Tingxi Guo, Kayoko Saso, Marcus O. Butler, Mark D. Minden, Thomas Kislinger, Naoto Hirano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP84Glyuses both class I and II mechanisms to constitutively present pe
Externí odkaz:
https://doaj.org/article/6fca40eaed414738a7794321edcd0a22
Autor:
Tingxi Guo, Kenji Chamoto, Munehide Nakatsugawa, Toshiki Ochi, Yuki Yamashita, Mark Anczurowski, Marcus O Butler, Naoto Hirano
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156114 (2016)
Invariant natural killer T (iNKT) cells recognize self-lipids presented by CD1d through characteristic TCRs, which mainly consist of the invariant Vα14-Jα18 TCRα chain and Vβ8.2, 7 or 2 TCRβ chains with hypervariable CDR3β sequences in mice. Th
Externí odkaz:
https://doaj.org/article/3cda122c78174bf59909393caef671e5
Autor:
Naoto Hirano, Marcus O. Butler, Yota Ohashi, Yukiko Matsunaga, Hiroshi Saijo, Kenji Sugata, Kenji Murata, Chung-Hsi Wang, Mark Anczurowski, Kayoko Saso, Brian Yeung, Tingxi Guo, Yuki Kagoya
Adoptive immunotherapy can induce sustained therapeutic effects in some cancers. Antitumor T-cell grafts are often individually prepared in vitro from autologous T cells, which requires an intensive workload and increased costs. The quality of the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cb5fb34a5edad3330af3b54055a68c
https://doi.org/10.1158/2326-6066.c.6550458
https://doi.org/10.1158/2326-6066.c.6550458
Autor:
Naoto Hirano, Marcus O. Butler, Yota Ohashi, Yukiko Matsunaga, Hiroshi Saijo, Kenji Sugata, Kenji Murata, Chung-Hsi Wang, Mark Anczurowski, Kayoko Saso, Brian Yeung, Tingxi Guo, Yuki Kagoya
Tables S1-S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f614a0f60ef8f44dc310b486e12f74
https://doi.org/10.1158/2326-6066.22543920.v1
https://doi.org/10.1158/2326-6066.22543920.v1
Autor:
Naoto Hirano, Marcus O. Butler, Yota Ohashi, Yukiko Matsunaga, Hiroshi Saijo, Kenji Sugata, Kenji Murata, Chung-Hsi Wang, Mark Anczurowski, Kayoko Saso, Brian Yeung, Tingxi Guo, Yuki Kagoya
Figures S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2781425cc26826a7765bd568dcd0c3a0
https://doi.org/10.1158/2326-6066.22543923
https://doi.org/10.1158/2326-6066.22543923
Autor:
Naoto Hirano, Marcus O. Butler, Masaki Yasukawa, Hiroshi Fujiwara, Tingxi Guo, Yuki Yamashita, Shinya Tanaka, Kenji Chamoto, Munehide Nakatsugawa, Toshiki Ochi
Adoptive transfer of T cells redirected by a high-affinity antitumor T-cell receptor (TCR) is a promising treatment modality for cancer patients. Safety and efficacy depend on the selection of a TCR that induces minimal toxicity and elicits sufficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a56f1ac964678bf8eb4b4fc816e8b7
https://doi.org/10.1158/2326-6066.c.6548594.v1
https://doi.org/10.1158/2326-6066.c.6548594.v1
Autor:
Naoto Hirano, Marcus O. Butler, Masaki Yasukawa, Hiroshi Fujiwara, Tingxi Guo, Yuki Yamashita, Shinya Tanaka, Kenji Chamoto, Munehide Nakatsugawa, Toshiki Ochi
Supplementary table S1. Amino acid sequences of A24/WT1235-related peptides. Supplementary figure S1. The TAK1β hemi-chain has a dominant role in dictating A24/WT1235 reactivity. Supplementary figure S2. All forty-five Jurkat 76/CD8 TCR transfectant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f03ad579335d423c81ae0aa575e4e3
https://doi.org/10.1158/2326-6066.22537889.v1
https://doi.org/10.1158/2326-6066.22537889.v1
Autor:
Timothy K. Lu, Andres Cubillos-Ruiz, Jose M. Lora, Tingxi Guo, James J. Collins, Paul F. Miller, Anna Sokolovska
Publikováno v:
Nature Reviews Drug Discovery. 20:941-960
The steadfast advance of the synthetic biology field has enabled scientists to use genetically engineered cells, instead of small molecules or biologics, as the basis for the development of novel therapeutics. Cells endowed with synthetic gene circui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1689880d9c6a8d180bf1ae70cc36a849
https://doi.org/10.1038/s41573-021-00285-3
https://doi.org/10.1038/s41573-021-00285-3