Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation

Autor: Larry Gerace, Howard J. Worman, Eric C. Schirmer, Arthur P. Hays, Cecilia Östlund, Denise A. Figlewicz, Tinglu Guan

Publikováno v: Ostlund, C, Guan, T, Figlewicz, D A, Hays, A P, Worman, H J, Gerace, L & Schirmer, E C 2009, ' Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation ', Biochemical and Biophysical Research Communications, vol. 389, no. 2, pp. 279-83 . https://doi.org/10.1016/j.bbrc.2009.08.133

Muscular dystrophy and peripheral neuropathy have been linked to mutations in genes encoding nuclear envelope proteins; however, the molecular mechanisms underlying these disorders remain unresolved. Nuclear envelope protein p19A is a protein of unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e4b0660c918b6a54e727100b36fa1
https://doi.org/10.1016/j.bbrc.2009.08.133

Overlapping Functions of Nuclear Envelope Proteins NET25 (Lem2) and Emerin in Regulation of Extracellular Signal-Regulated Kinase Signaling in Myoblast Differentiation

Autor: Larry Gerace, Michael D. Huber, Tinglu Guan

Publikováno v: Molecular and Cellular Biology. 29:5718-5728

Mutations in certain nuclear envelope (NE) proteins cause muscular dystrophies and other disorders, but the disease mechanisms remain unclear. The nuclear envelope transmembrane protein NET25 (Lem2) is a truncated paralog of MAN1, an NE component lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cc461a61b81387ad1de2a2fc83e5ba
https://doi.org/10.1128/mcb.00270-09

Synergy of Silent and Hot Spot Mutations in Importin β Reveals a Dynamic Mechanism for Recognition of a Nuclear Localization Signal

Autor: Larry Gerace, Carolin Koerner, Gino Cingolani, Tinglu Guan

Publikováno v: Journal of Biological Chemistry. 278:16216-16221

Molecular recognition of the importin beta-binding (IBB) domain of importin alpha by importin beta is critical for the nuclear import of protein cargoes containing a classical nuclear localization signal. We have studied the function of four conserve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7350deca04bd6ef72a452c7331c78c58
https://doi.org/10.1074/jbc.m301137200

Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export

Autor: Larry Gerace, Klaus M. Hahn, P. Frosst, Tinglu Guan, Cecilia Subauste

Publikováno v: The Journal of Cell Biology

Tpr is a coiled-coil protein found near the nucleoplasmic side of the pore complex. Since neither the precise localization of Tpr nor its functions are well defined, we generated antibodies to three regions of Tpr to clarify these issues. Using light

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6c514b1e2beaa0f009431a03105779
https://doi.org/10.1083/jcb.200106046

Regulation of Adenovirus Membrane Penetration by the Cytoplasmic Tail of Integrin β5

Autor: Glen R. Nemerow, Tinglu Guan, David A. Cheresh, Kena Wang

Publikováno v: Journal of Virology. 74:2731-2739

Adenovirus (Ad) cell entry involves sequential interactions with host cell receptors that mediate attachment (CAR), internalization (alphavbeta3 and alphavbeta5), and penetration (alphavbeta5) of the endosomal membrane. These events allow the virus t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2367416803ccab23cb760866edf7f7be
https://doi.org/10.1128/jvi.74.6.2731-2739.2000