Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tingjie Guo"'
Autor:
Luca F. Roggeveen, Tingjie Guo, Lucas M. Fleuren, Ronald Driessen, Patrick Thoral, Reinier M. van Hest, Ron A. A. Mathot, Eleonora L. Swart, Harm-Jan de Grooth, Bas van den Bogaard, Armand R. J. Girbes, Rob J. Bosman, Paul W. G. Elbers
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)
Abstract Background Adequate antibiotic dosing may improve outcomes in critically ill patients but is challenging due to altered and variable pharmacokinetics. To address this challenge, AutoKinetics was developed, a decision support system for bedsi
Externí odkaz:
https://doaj.org/article/6a01424511e0433f9b3a6d071324f5c2
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1175 (2023)
Early prediction, quantification and translation of cardiovascular hemodynamic drug effects is essential in pre-clinical drug development. In this study, a novel hemodynamic cardiovascular systems (CVS) model was developed to support these goals. The
Externí odkaz:
https://doaj.org/article/cc5700369e59410fb74eaf1d2540d02e
Autor:
Laura B. Zwep, Kevin L. W. Duisters, Martijn Jansen, Tingjie Guo, Jacqueline J. Meulman, Parth J. Upadhyay, J. G. Coen vanHasselt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 4, Pp 350-361 (2021)
Abstract Pharmacometric modeling can capture tumor growth inhibition (TGI) dynamics and variability. These approaches do not usually consider covariates in high‐dimensional settings, whereas high‐dimensional molecular profiling technologies (“o
Externí odkaz:
https://doaj.org/article/b569bda0fd6a4dffa8e75e560977a350
Autor:
Luca F. Roggeveen, Lucas M. Fleuren, Tingjie Guo, Patrick Thoral, Harm Jan de Grooth, Eleonora L. Swart, Thomas L. T. Klausch, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman, Paul W. G. Elbers
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics in these patients, gu
Externí odkaz:
https://doaj.org/article/2b27308607ef4e9fa44e0add70ba8348
Autor:
Lucas M. Fleuren, Luca F. Roggeveen, Tingjie Guo, Petr Waldauf, Peter H. J. van der Voort, Rob J. Bosman, Eleonora L. Swart, Armand R. J. Girbes, Paul W. G. Elbers
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-9 (2019)
Abstract Background Antibiotic exposure in intensive care patients with sepsis is frequently inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the intensive care, as critically ill patients have altered and fluctu
Externí odkaz:
https://doaj.org/article/bc3f6b1b19dc470598477a7381dd8d8b
Autor:
Luca F. Roggeveen, Tingjie Guo, Ronald H. Driessen, Lucas M. Fleuren, Patrick Thoral, Peter H. J. van der Voort, Armand R. J. Girbes, Rob J. Bosman, Paul Elbers
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
IntroductionAntibiotic dosing in critically ill patients is challenging because their pharmacokinetics (PK) are altered and may change rapidly with disease progression. Standard dosing frequently leads to inadequate PK exposure. Therapeutic drug moni
Externí odkaz:
https://doaj.org/article/14b67b93653c458aa8af08df6f0b2300
Publikováno v:
Clinical Pharmacokinetics. 62:519-532
Autor:
Feiyan Liu, Linda B. S. Aulin, Tingjie Guo, Elke H. J. Krekels, Matthijs Moerland, Piet H. van der Graaf, Johan G. C. van Hasselt
Publikováno v:
British Journal of Clinical Pharmacology, 88(12), 5420-5427. WILEY
Clinical studies in healthy volunteers challenged with lipopolysaccharide (LPS), a constituent of the cell wall of Gram-negative bacteria, represent a key model to characterize the Toll-like receptor 4 (TLR4)-mediated inflammatory response. Here, we
Publikováno v:
Antimicrob Agents Chemother
Antimicrobial Agents and Chemotherapy, 66(8):e0036622
Antimicrobial Agents and Chemotherapy, 66(8):e0036622
BackgroundQuantitative systems pharmacology (QSP) modeling of the host-immune response against Mtb can inform rational design of host-directed therapies (HDTs). We aimed to develop a QSP framework to evaluate the effects of metformin-associated autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d888289369943673a02dcb1896adb7
https://hdl.handle.net/1887/3494210
https://hdl.handle.net/1887/3494210
Autor:
Nicole P. Juffermans, Tingjie Guo, Pieter R. Tuinman, Stephan A. Loer, Marcus J. Schultz, Armand R. J. Girbes, J. Juschten, H. J. de Grooth
Publikováno v:
Juschten, J, Tuinman, P R, Guo, T, Juffermans, N P, Schultz, M J, Loer, S A, Girbes, A R J & de Grooth, H J 2021, ' Between-trial heterogeneity in ARDS research ', Intensive Care Medicine, vol. 47, no. 4, pp. 422-434 . https://doi.org/10.1007/s00134-021-06370-w, https://doi.org/10.1007/s00134-021-06370-w
Intensive Care Medicine
Intensive Care Medicine
Purpose Most randomized controlled trials (RCTs) in patients with acute respiratory distress syndrome (ARDS) revealed indeterminate or conflicting study results. We aimed to systematically evaluate between-trial heterogeneity in reporting standards a