Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Tinggui Yin"'
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
PDF - 1128K, Figure S1. Knockdown of CDK7 and CDK9 can inhibit RNAP II CTD P-Ser2 and P-Ser5. Figure S2. LY2857785 and flavopiridol inhibit MCL-1, XIAP protein expression and induce CASP-3 and cleaved PARP in AML cell MV-4-11. Table S1. LY2857785 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb62eb48bfbf19159c380c73cb9da0d
https://doi.org/10.1158/1535-7163.22500105.v1
https://doi.org/10.1158/1535-7163.22500105.v1
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
XLSX - 54K, Table S2. 261 probsets gene signature in sens and res cell lines in Excel format.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70fa29c964bb208bbfee904a5d0548e
https://doi.org/10.1158/1535-7163.22500102
https://doi.org/10.1158/1535-7163.22500102
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Supplementary Table 1. In vitro anticancer activity of LY2523355 against a panel of commonly used cancer cell lines; supplementary Table 2. Anticancer activity of LY2523355 in NCI-60 assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a65911a747f00062ac61a9596c14f42
https://doi.org/10.1158/1535-7163.22506618.v1
https://doi.org/10.1158/1535-7163.22506618.v1
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805b19504f4ca7d3dd3ca23723e6c77
https://doi.org/10.1158/1535-7163.c.6536355
https://doi.org/10.1158/1535-7163.c.6536355
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Intervention of cancer cell mitosis by antitubulin drugs is among the most effective cancer chemotherapies. However, antitubulin drugs have dose-limiting side effects due to important functions of microtubules in resting normal cells and are often re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed1dda9c315451439788b0da0e62655
https://doi.org/10.1158/1535-7163.c.6538446.v1
https://doi.org/10.1158/1535-7163.c.6538446.v1
Autor:
Sheng-Bin Peng, Gregory D. Plowman, James J. Starling, James R. Henry, Ilaria Conti, Lysiane Huber, Yong Gang Yue, Swee Seong Wong, Igor Mochalkin, Vipin Yadav, Sean Buchanan, Tinggui Yin, Robert D. Van Horn, Youyan Zhang, Shih-Hsun Chen
Supplementary Figure S1. Validation of BRAF deletion in BxPC-3 cells by Sanger's sequencing method. Supplementary Figure S2. BRAF deletion (deltaBRAF), but not WT BRAF, is able to transform cells. Supplementary Figure S3. Validation of in situ PLA in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436628872cb0b1f40e19a206dbd41888
https://doi.org/10.1158/2159-8290.22531479
https://doi.org/10.1158/2159-8290.22531479
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Supplementary Figure 1 (A-C). LY2523355 has potent and selective activity against microtubule-stimulated Eg5 ATPase activity but unlike antitubulins, has no effect on microtubule dynamics in vitro; supplementary Figure 2 (A-E). LY2523355 causes cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327deaa062a75d5daccf35952d6b60e
https://doi.org/10.1158/1535-7163.22506624
https://doi.org/10.1158/1535-7163.22506624
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Figure Legends to supplementary Figures 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acf89d9470e8c0b4b636be6a70853a0
https://doi.org/10.1158/1535-7163.22506621.v1
https://doi.org/10.1158/1535-7163.22506621.v1
Autor:
Xueqian Gong, Wenjuan Wu, Youyan Zhang, R.D. Van Horn, S-H Chen, Richard P. Beckmann, Sean Buchanan, Phillip W Iversen, Lysiane Huber, Teresa F. Burke, Tinggui Yin, Ramon V. Tiu, Shripad V. Bhagwat, S-B Peng, Jason Manro
Publikováno v:
Oncogene. 37:821-832
KRAS, NRAS and BRAF mutations are among the most important oncogenic drivers in many major cancer types, such as melanoma, lung, colorectal and pancreatic cancer. There is currently no effective therapy for the treatment of RAS mutant cancers. LY3009
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a1037c2c823ec0676981822a09dfd4
https://doi.org/10.1038/onc.2017.384
https://doi.org/10.1038/onc.2017.384
Autor:
R. Brown, John R. Stille, Eyas Raddad, Charles Edward Ruegg, William C. Roell, Robert D. Van Horn, Tinggui Yin, Sheng-Bin Peng, Victor H. Obungu, Victor J. Wroblewski
Publikováno v:
Oncotarget
Stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 play a critical role in mobilization and redistribution of immune cells and hematopoietic stem cells (HSCs). We evaluated effects of two CXCR4-targeting agents, peptide antagonist LY2510924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e51967ed3ed8abe1ff2c0c7814a804
http://europepmc.org/articles/PMC5706900
http://europepmc.org/articles/PMC5706900