Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ting-Nien Lin"'
Autor:
Natalie P Archer, Virginia Perez-Andreu, Ulrik Stoltze, Michael E Scheurer, Anna V Wilkinson, Ting-Nien Lin, Maoxiang Qian, Charnise Goodings, Michael D Swartz, Nalini Ranjit, Karen R Rabin, Erin C Peckham-Gregory, Sharon E Plon, Pedro A de Alarcon, Ryan C Zabriskie, Federico Antillon-Klussmann, Cesar R Najera, Jun J Yang, Philip J Lupo
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0180488 (2017)
We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more
Externí odkaz:
https://doaj.org/article/66ee2b0dd9024e2a833cc9b23e7f6b6b
Autor:
Ting-Nien Lin, 林庭年
98
Enduring great company, almost all have core values. While a company''s core values, business leaders, mostly from the belief, and through the rituals, slogans, and other pipeline systems to deliver its organizational culture. Organizational
Enduring great company, almost all have core values. While a company''s core values, business leaders, mostly from the belief, and through the rituals, slogans, and other pipeline systems to deliver its organizational culture. Organizational
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/32455488814343896704
Autor:
Takaya Moriyama, Karen R. Rabin, Jeffery M. Klco, Rebekah Baskin-Doerfler, Charles G. Mullighan, Katherine Verbist, Ninad Oak, Jun J. Yang, Kim E. Nichols, Rina Nishii, Keito Hoshitsuki, Mignon L. Loh, Zhenhua Li, Maoxiang Qian, Elizabeth A. Raetz, Allen Eng Juh Yeoh, Mackenzie Bloom, Stephen P. Hunger, Monika L. Metzger, Xujie Zhao, Wentao Yang, Wenjian Yang, Jinghui Zhang, Scott Newman, Julie M. Gastier-Foster, Melissa A. Burns, Gang Wu, Ting-Nien Lin, Ching-Hon Pui
Publikováno v:
Blood. 137:364-373
There is growing evidence supporting an inherited basis for susceptibility to acute lymphoblastic leukemia (ALL) in children. In particular, we and others reported recurrent germline ETV6 variants linked to ALL risk, which collectively represent a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a13e78449aecfa40b786a3679941e19
https://doi.org/10.1182/blood.2020006164
https://doi.org/10.1182/blood.2020006164
Autor:
Jie Zhao, Ke Xu, Fan Yang, Ludmil B. Alexandrov, Edgar Sioson, Cheng Cheng, Samuel W. Brady, Shuhong Shen, Lele Sun, Liqing Tian, Benshang Li, Heather L. Mulder, Tianyi Wang, Yu Liu, Diane Flasch, James R. Downing, Ting Nien Lin, Xiaofan Zhu, Hui Zhang, Lijuan Du, Ching-Hon Pui, Matthew A. Myers, Yongjin Li, Ningling Wang, Michael Rusch, Karol Szlachta, Xiaotu Ma, Liu Yang, Jingyan Tang, Bin-Bing S. Zhou, Xin Zhou, Benjamin J. Raphael, Jinghui Zhang, Hui Li, Hui Ying Sun, Lixia Ding, Li Dong, Ying Shao, Jiaoyang Cai, Jingliao Zhang, Yingchi Zhang, Hongye Sun, Michael N. Edmonson, Kohei Hagiwara, John Easton, Yanling Liu, Jun J. Yang
Publikováno v:
Blood
To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients. Relapse-specific somatic alteration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae14692e7b8ad521ac621cf58128a54
https://doi.org/10.1182/blood.2019002220
https://doi.org/10.1182/blood.2019002220
Autor:
Tomohiro Morio, Shirley Kow Yin Kham, Atsushi Manabe, Kentaro Kihira, Nan Jiang, Matthias Schwab, Chase C. Suiter, Rina Nishii, Masatoshi Takagi, Jun J. Yang, Takaya Moriyama, Karen R. Rabin, Ute Hofmann, Lie Li, Hiroki Hori, Laura J. Janke, Hidemi Toyoda, Ting-Nien Lin, Motohiro Kato, Katsuyoshi Koh, Wenjian Yang, Allen Eng Juh Yeoh
Publikováno v:
Blood. 131:2466-2474
Thiopurines (eg, 6-mercaptopurine [MP]) are highly efficacious antileukemic agents, but they are also associated with dose-limiting toxicities. Recent studies by us and others have identified inherited NUDT15 deficiency as a novel genetic cause of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f029485f75587177c15dfc00ec96cec
https://doi.org/10.1182/blood-2017-11-815506
https://doi.org/10.1182/blood-2017-11-815506
Autor:
Sima Jeha, Takaya Moriyama, Hany Ariffin, Ting-Nien Lin, Shirley Kow Yin Kham, Yung-Li Yang, William E. Evans, Mary V. Relling, Wenjian Yang, Chengcheng Liu, Dong-Tsamn Lin, Chih-Hsiang Yu, Rina Nishii, Jun J. Yang, Ching-Hon Pui, Allen Eng Juh Yeoh
Publikováno v:
Blood. 130:1209-1212
Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose-limiting hematopoietic toxicities, which is partly explained by inherited g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344de226899fdaedb75b64ef5365ae2a
https://doi.org/10.1182/blood-2017-05-782383
https://doi.org/10.1182/blood-2017-05-782383
Autor:
Ching-Hon Pui, Hui Zhang, Jin Yang, Jian Pan, Jun Lu, Meimei Chang, Ah-Moy Tan, Shaoyan Hu, Guoqing Du, Maoxiang Qian, Hailong He, Anders Jacobsen Skanderup, Yu Guo, Ting-Nien Lin, Xujie Zhao, Chunliang Li, Allen Eng Juh Yeoh, Yong Cheng, Thuan Chong Quah, Jun J. Yang, Shirley Kow-Yin Kham, Hany Ariffin
Publikováno v:
Blood. 129:3264-3268
Publisher's Note: There is an [Inside Blood Commentary][1] on this article in this issue. To the editor: Our understanding of acute lymphoblastic leukemia (ALL) has expanded tremendously in the past few years because of large-scale genomic studies.[1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07484fde89543a4c0daf5774a92414d
https://doi.org/10.1182/blood-2017-03-771162
https://doi.org/10.1182/blood-2017-03-771162
Autor:
Hiroki Hori, Ting-Nien Lin, Takaya Moriyama, Atsushi Manabe, Katsuyoshi Koh, Rina Nishii, Kentaro Kihira, Motohiro Kato, Nersting Jacob, Jun J. Yang, Hiroto Inaba, Hidemi Toyoda, Kjeld Schmiegelow
Publikováno v:
Pharmacogenetics and Genomics. 27:236-239
Thiopurines [e.g. mercaptopurine (MP)] are widely used as chemotherapeutic agents in the treatment of pediatric acute lymphoblastic leukemia with dose-limiting hematopoietic toxicity. Recently, germline variants in NUDT15 have been identified as a ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2a3bbf852a0731994c284423a4c4e6
https://doi.org/10.1097/fpc.0000000000000282
https://doi.org/10.1097/fpc.0000000000000282
Autor:
Matthias Schwab, Cesar R. Najera, Kjeld Schmiegelow, Zhiwei Chen, Cynthia Jeffries, Ching-Hon Pui, Mary V. Relling, Tomoya Isobe, Deepa Bhojwani, Allen Eng Juh Yeoh, Takaya Moriyama, Hiroki Hori, Atsushi Manabe, Keito Hoshitsuki, Yan Lu, Rina Nishii, Kentaro Kihira, Federico Antillon Klussmann, Robert McCorkle, Wenjian Yang, Jun J. Yang, Virginia Perez-Andreu, Hiroto Inaba, Katsuyoshi Koh, Lie Li, Shirley Kow-Yin Kham, Yoshihiro Komada, Xujie Zhao, Ting-Nien Lin, Motohiro Kato, Edwynn Kean Hui Chiew, Jacob Nersting, Ute Hofmann, William E. Evans
Publikováno v:
Nature Genetics. 48:367-373
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbccfafb3316d53a99c0cbb7a96a3ae
https://doi.org/10.1038/ng.3508
https://doi.org/10.1038/ng.3508
Autor:
Takaya, Moriyama, Yung-Li, Yang, Rina, Nishii, Hany, Ariffin, Chengcheng, Liu, Ting-Nien, Lin, Wenjian, Yang, Dong-Tsamn, Lin, Chih-Hsiang, Yu, Shirley, Kham, Ching-Hon, Pui, William E, Evans, Sima, Jeha, Mary V, Relling, Allen Eng-Juh, Yeoh, Jun J, Yang
Publikováno v:
Blood. 130(10)
Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose-limiting hematopoietic toxicities, which is partly explained by inherited g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d4c766d2ecccd0eea98c0312307a763
https://pubmed.ncbi.nlm.nih.gov/28659275
https://pubmed.ncbi.nlm.nih.gov/28659275