Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ting-Lan Chiu"'
Autor:
Ting Lan Chiu, Chih Hung Lo, Benjamin D. Grant, Nagamani Vunnam, Tory M. Schaaf, David D. Thomas, Andrew K. Lewis, Benjamin E. Brummel, Jonathan N. Sachs, Prachi Bawaskar
Publikováno v:
SLAS Discovery. 22:950-961
Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that binds tumor necrosis factor or lymphotoxin-alpha and plays a critical role in regulating the inflammatory response. Upregulation of these ligands is associated with inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83d72ce00b50b3b257f70376fd25934
https://doi.org/10.1177/2472555217706478
https://doi.org/10.1177/2472555217706478
Autor:
Michael A. Walters, Ting Lan Chiu, Barry C. Finzel, Jon E. Hawkinson, Jonathan Solberg, Rodney L. Johnson, Elbek K. Kurbanov, Elizabeth A. Amin, Kimberly M. Maize, Jenna Fernandez, Subhashree Francis
Publikováno v:
Journal of Medicinal Chemistry. 58:8723-8733
The lethal factor (LF) enzyme secreted by Bacillus anthracis is a zinc hydrolase that is chiefly responsible for anthrax-related cell death. Although many studies of the design of small molecule LF inhibitors have been conducted, no LF inhibitor is y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e437229548a785354f0d64762cefae0
https://doi.org/10.1021/acs.jmedchem.5b01446
https://doi.org/10.1021/acs.jmedchem.5b01446
Autor:
Ting-Lan Chiu1,2, Mulakala, Chandrika1,2, Lambris, John D.3, Kaznessis, Yiannis N.1,2 yiannis@cems.umn.edu
Publikováno v:
Chemical Biology & Drug Design. Oct2008, Vol. 72 Issue 4, p249-256. 8p. 2 Diagrams, 4 Charts.
Publikováno v:
Chemical research in toxicology. 29(3)
Arylamines (AAs) and heterocyclic aromatic amines (HAAs) are structurally related carcinogens formed during the combustion of tobacco or cooking of meat. They undergo cytochrome P450 mediated N-hydroxylation to form metabolites which bind to DNA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c7c49c00c51d6b5e01d7ef8f2bc669
https://pubmed.ncbi.nlm.nih.gov/26824300
https://pubmed.ncbi.nlm.nih.gov/26824300
Autor:
Sunil A. David, Gunda I. Georg, David Vander Velde, John T. Henri, Richard H. Himes, Sajiv K. Nair, Ting Lan Chiu, Bollu S. Reddy, Ramappa Chakrasali, Elizabeth A. Amin, Emily A. Reiff, Jack F. Greiner
Publikováno v:
The Journal of Organic Chemistry. 75:86-94
Three photoaffinity labeled derivatives of epothilone D were prepared by total synthesis, using efficient novel asymmetric synthesis methods for the preparation of two important synthetic building blocks. The key step for the asymmetric synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6fba875342da743f14b5984997024e
https://doi.org/10.1021/jo901752v
https://doi.org/10.1021/jo901752v
Autor:
David VanderVelde, Sajiv K. Nair, Gunda I. Georg, Richard H. Himes, Emily A. Reiff, Oliver E. Hutt, Jack F. Greiner, Bollu S. Reddy, Jun Inagaki, Elizabeth A. Amin, Ting Lan Chiu, John T. Henri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3293-3296
The total synthesis of 22-(3-azidobenzoyloxy)methyl epothilone C is described as a potential photoaffinity probe to elucidate the beta-tubulin binding site. A sequential Suzuki-aldol-Yamaguchi macrolactonization strategy was utilized employing a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674c6652d0607744da6be034a4c91fc2
https://doi.org/10.1016/j.bmcl.2009.04.077
https://doi.org/10.1016/j.bmcl.2009.04.077
Publikováno v:
Proceedings of the National Academy of Sciences. 105:8855-8860
One of the challenges faced in malarial control is the acquisition of insecticide resistance that has developed in mosquitoes that are vectors for this disease. Anopheles gambiae , which has been the major mosquito vector of the malaria parasite Plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8857a188ec3a39a872e7a24a81057fc
https://doi.org/10.1073/pnas.0709249105
https://doi.org/10.1073/pnas.0709249105
Autor:
Ting-Lan Chiu, Goldstein, Richard A.
Publikováno v:
Journal of Chemical Physics; 9/15/1997, Vol. 107 Issue 11, p4408, 8p, 8 Graphs
Autor:
Ting Lan Chiu, Young Kyung Bae, Craig M. Flory, Yelena V. Grinkova, Ameeta Kelekar, Stephen G. Sligar, M. Gerard O'Sullivan, Adela Galván, Irina F. Sevrioukova, Kalpna Gupta, Beverly Norris, Ian A. Blair, Elizabeth A. Ambrose, Fernando Luna, Ilia G. Denisov, John D. Lipscomb, Eric A. Hanse, Haitao Chu, Daniel S. Swedien, Robert J. Schumacher, William M. Atkins, Rebecca A. D. Cuellar, Gunda I. Georg, Julia Wulfkuhle, Zhijun Guo, Rosa I. Gallagher, Thomas L. Poulos, Qing Cao, Vanessa Wankhede Langenfeld, Xia Zhang, John R. Falck, Juan Alvarez, Emanuel F. Petricoin, Dafydd G. Thomas, Jorge H. Capdevila, David Potter, Justin D. Stamschror
Publikováno v:
Cell Chemical Biology. 24:1259-1275.e6
The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609abd584fa3973a5ec9c305d29ee4dd
https://doi.org/10.1016/j.chembiol.2017.08.009
https://doi.org/10.1016/j.chembiol.2017.08.009
How to generate improved potentials for protein tertiary structure prediction: A lattice model study
Autor:
Ting Lan Chiu, Richard A. Goldstein
Publikováno v:
Proteins: Structure, Function, and Genetics. 41:157-163
Success in the protein structure prediction problem relies heavily on the choice of an appropriate potential function. One approach toward extracting these potentials from a database of known protein structures is to maximize the Z-score of the datab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab4bb4bb26f575333b57aa5c4bcea54b
https://doi.org/10.1002/1097-0134(20001101)41:2<157::aid-prot10>3.0.co
https://doi.org/10.1002/1097-0134(20001101)41:2<157::aid-prot10>3.0.co