Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients

Autor: Ming-Han Chen, Ming-Ting Huang, Wen-Kuang Yu, Shinn-Shing Lee, Jia-Horng Wang, Ting-Jen R. Cheng, Michael R. Bowman, Shie-Liang Hsieh

Publikováno v: Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-12 (2019)

Abstract Background Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodies (MoAbs) attenuat

Externí odkaz: https://doaj.org/article/c062eb9bc197464890eb2f07a165030d

Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1

Autor: Chi-Huey Wong, Ting-Jen R. Cheng, Wei-Chen Lin, Narayana Murthy Sabbavarapu, Chiao-Yuan Fan, Shang-Cheng Hung, Li-Ting Chiu, Chih-Chung Wu

Publikováno v: Journal of the American Chemical Society. 142:5282-5292

Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09685fbaa0382c841657aa48d243eb1b
https://doi.org/10.1021/jacs.0c00005

Immunogenicity Evaluation of N-Glycans Recognized by HIV Broadly Neutralizing Antibodies

Autor: Vidya S. Shivatare, Yang-Yu Cheng, Ting-Jen R. Cheng, Sachin S. Shivatare, Hong-Yang Chuang, Chi-Huey Wong, Chung-Yi Wu, Tsung-I Tsai

Publikováno v: ACS Chem Biol

While the improved treatment of human immunodeficiency virus type 1 (HIV-1) infection is available, the development of an effective and safe prophylactic vaccine against HIV-1 is still an unrealized goal. Encouragingly, the discovery of broadly neutr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a25bb47685ade6ca5c9d4c1c448ff8f
https://pubmed.ncbi.nlm.nih.gov/34649433

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

Autor: Ting-Jen R. Cheng, Jiun-Jie Shie, Jia Tsrong Jan, Ting Hung Chou, Wen-Bin Yang, Wei-Chieh Cheng, Chi-Huey Wong, Shang-Cheng Hung, Rong-Jie Chein, Hsiu Hua Ma, Cheng Wei Cheng, Pi-Hui Liang, Xiaorui Chen, Ying-Ta Wu, Che Ma, Yu Pu Juang, Shi Shan Mao

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118(5):e20211579118

Significance COVID-19 is a global pandemic currently lacking an effective cure. We used a cell-based infection assay to screen more than 3,000 agents used in humans and animals and identified 15 with antiinfective activity, ranging from 0.1 nM to 50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006ff36b872509529e809eb42882f41c
https://doi.org/10.1073/pnas.2021579118

Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes

Autor: Kuo-I Lin, Chi-Huey Wong, Yi-An Ko, Che Ma, Shih-Chi Wang, Ting-Jen R. Cheng, Hsin-Yu Liao

Publikováno v: Proc Natl Acad Sci U S A

Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have been directed toward development of a universal v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915b66fafc5cf5d916437baf3ddb79ab
https://pubmed.ncbi.nlm.nih.gov/32669430