Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway

Autor: Ting-Yang Hsieh, Yi Chang, Su-Jane Wang

Publikováno v: Molecules, Vol 27, Iss 9, p 2638 (2022)

The neuroprotective properties of piperine, the major alkaloid extracted from black pepper, have been under investigation, but its mechanism of action in excitotoxicity is still poorly understood. This study aimed to evaluate the protective effects o

Externí odkaz: https://doaj.org/article/83fef2dcd75449ba95ab06c95ac83442

Piperine-mediated suppression of voltage-dependent Ca2+influx and glutamate release in rat hippocampal nerve terminals involves 5HT1Areceptors and G protein βγ activation

Autor: Su-Jane Wang, Ting Yang Hsieh, Yi Chang

Publikováno v: Food & Function. 10:2720-2728

Piperine is the crucial alkaloid component of black pepper (Piper nigrum Linn.) and has neuroprotective effects. Because inhibition of glutamatergic excitatory neurotransmission is a possible mechanism involved in neuroprotection, we investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4737ae0491397492ed2642fa869ceec9
https://doi.org/10.1039/c8fo02189a

Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca2+ Channel Suppression: A Possible Neuroprotective Mechanism

Autor: Yi-Chieh Hung, Pei-Wen Hsieh, Ting-Yang Hsieh, Su-Jane Wang, Yi-Hsiu Kuo, Jinn-Rung Kuo

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11447, p 11447 (2021)

The glutamatergic neurotransmitter system has received substantial attention in research on the pathophysiology and treatment of neurological disorders. The study investigated the effect of the polyphenolic compound chlorogenic acid (CGA) on glutamat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c297a0e0758090dccbf7b28c6df9d56f
https://doi.org/10.3390/ijms222111447

Allicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca

Autor: Cheng-Wei, Lu, Chi-Feng, Hung, Tzu-Yu, Lin, Ting Yang, Hsieh, Su Jane, Wang

Publikováno v: Journal of medicinal food. 22(7)

Evidence indicates that indirect inhibitory regulation of glutamatergic transmission, via reducing glutamate release, may induce neuroprotection. The present work was designed to examine whether allicin, a major component of garlic with neuroprotecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c84976a094a3884b4d3f9764c4320ce6
https://pubmed.ncbi.nlm.nih.gov/30985232

Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway.

Autor: Hsieh, Ting-Yang¹ (AUTHOR) david711young@gmail.com, Chang, Yi² (AUTHOR) m004003@ms.skh.org.tw, Wang, Su-Jane^3,4 (AUTHOR) med0003@mail.fju.edu.tw

Publikováno v: Molecules. May2022, Vol. 27 Issue 9, p2638-2638. 16p.