Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Ting Wei Mu"'
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107356- (2024)
Recent advances in genetic diagnosis identified variants in genes encoding GABAA receptors as causative for genetic epilepsy. Here, we selected eight disease-associated variants in the α1 subunit of GABAA receptors causing mild to severe clinical ph
Externí odkaz:
https://doaj.org/article/7b37f9d84fe544c290db0fec354b5c63
Autor:
Ya-Juan Wang, Xiao-Jing Di, Pei-Pei Zhang, Xi Chen, Marnie P Williams, Dong-Yun Han, Raad Nashmi, Brandon J Henderson, Fraser J Moss, Ting-Wei Mu
Publikováno v:
eLife, Vol 13 (2024)
Protein homeostasis (proteostasis) deficiency is an important contributing factor to neurological and metabolic diseases. However, how the proteostasis network orchestrates the folding and assembly of multi-subunit membrane proteins is poorly underst
Externí odkaz:
https://doaj.org/article/3c4e1af339594e16b884f8208cc9c4b6
Autor:
Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting-Wei Mu
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABAA subunits
Externí odkaz:
https://doaj.org/article/569f39d2a4334662858040e0811c4d49
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104754- (2022)
Summary: The endoplasmic reticulum membrane complex (EMC) plays a critical role in the biogenesis of tail-anchored proteins and a subset of multi-pass membrane proteins in the endoplasmic reticulum (ER). However, because of nearly exclusive expressio
Externí odkaz:
https://doaj.org/article/7968e75a471f4833b1bacde1523fab6b
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically
Externí odkaz:
https://doaj.org/article/7568307c58bf4ab18065a1438ff1225c
Autor:
Dawid Krokowski, Bo-Jhih Guan, Jing Wu, Yuke Zheng, Padmanabhan P. Pattabiraman, Raul Jobava, Xing-Huang Gao, Xiao-Jing Di, Martin D. Snider, Ting-Wei Mu, Shijie Liu, Brian Storrie, Eric Pearlman, Anna Blumental-Perry, Maria Hatzoglou
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2895-2910 (2017)
Summary: GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function in hyperosmotic stress through its well-known role in the integrated stress response (ISR) pathway. Adaptation to hyperosmotic stress is important for t
Externí odkaz:
https://doaj.org/article/d251b901866045d39c6dbea94d5add74
Publikováno v:
bioRxiv
Recent advances in genetic diagnosis identified variants in genes encoding GABAAreceptors as causative for genetic epilepsy. Here, we selected eight disease-associated variants in the α1 subunit of GABAAreceptors causing mild to severe clinical phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600e0155eeba2b8093cc2183f2d2cdce
https://europepmc.org/articles/PMC10153171/
https://europepmc.org/articles/PMC10153171/
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207948 (2018)
Biogenesis of membrane proteins is controlled by the protein homeostasis (proteostasis) network. We have been focusing on protein quality control of γ-aminobutyric acid type A (GABAA) receptors, the major inhibitory neurotransmitter-gated ion channe
Externí odkaz:
https://doaj.org/article/d146b7fd7b744215a70ac2a8c47f18c5
Autor:
Ya-Juan Wang, Xiao-Jing Di, Dong-Yun Han, Raad Nashmi, Brandon J. Henderson, Fraser J. Moss, Ting-Wei Mu
Protein homeostasis (proteostasis) deficiency is an important contributing factor to neurodegenerative, neurological, and metabolic diseases. However, how the proteostasis network orchestrates the folding and assembly of multi-subunit membrane protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cfe6d3a7a4ebc3ca4bb34747512832d
https://doi.org/10.1101/2022.10.24.513629
https://doi.org/10.1101/2022.10.24.513629
Publikováno v:
Epilepsy ISBN: 9780645332049
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88ad3b75e47757da9b834c2fc0a4a9b4
https://doi.org/10.36255/exon-publications-epilepsy-gaba-receptor
https://doi.org/10.36255/exon-publications-epilepsy-gaba-receptor