Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Ting‐Fen Tsai"'
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Autor:
Zhao-Qing Shen, Cheng-Yen Chang, Chi-Hsiao Yeh, Chung-Kuang Lu, Hao-Chih Hung, Tai-Wen Wang, Kuan-Sheng Wu, Chien-Yi Tung, Ting-Fen Tsai
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Abstract Background CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, a persistently high level of CISD2 promotes longevity and ameliorates
Externí odkaz:
https://doaj.org/article/a234936568064c509ab7ba49f8c5352b
Autor:
I-Wen Wu, Tsung-Hsien Tsai, Chi-Jen Lo, Yi-Ju Chou, Chi-Hsiao Yeh, Yun-Hsuan Chan, Jun-Hong Chen, Paul Wei-Che Hsu, Heng-Chih Pan, Heng-Jung Hsu, Chun-Yu Chen, Chin-Chan Lee, Yu-Chiau Shyu, Chih-Lang Lin, Mei-Ling Cheng, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-10 (2022)
Abstract Diabetic kidney disease is the leading cause of end-stage kidney disease worldwide; however, the integration of high-dimensional trans-omics data to predict this diabetic complication is rare. We develop artificial intelligence (AI)-assisted
Externí odkaz:
https://doaj.org/article/ab4ebbc5ed2d46b3875d0d9cf12463aa
Autor:
Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu, Ting-Fen Tsai
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-21 (2022)
Abstract Background The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspa
Externí odkaz:
https://doaj.org/article/d11df834c11b41a3ac3d234147818e8f
Autor:
Wei-Ju Lin, Wei-Ju Lee, Li-Ning Peng, Yi-Long Huang, Chien-Yi Tung, Chi-Hung Lin, Ting-Fen Tsai, Liang-Kung Chen
Publikováno v:
Experimental Gerontology, Vol 172, Iss , Pp 112053- (2023)
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker. Anti-TNF-α, a natura
Externí odkaz:
https://doaj.org/article/2a9e3e03109147ba8a8d80655a53bc6d
Autor:
Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Autophagy and the ubiquitin–proteasome system (UPS) are cellular quality control processes, but their coordination remains unclear. Here, the authors show that branched ubiquitination of VPS34 functions as a switch between UPS and autophagy and has
Externí odkaz:
https://doaj.org/article/48717331846c4d5699d2e8a3c33c5192
Autor:
Kuei-Ching Hsiung, Kuan-Yu Liu, Ting-Fen Tsai, Sawako Yoshina, Shohei Mitani, Bertrand Chin-Ming Tan, Szecheng J. Lo
Publikováno v:
Biomedical Journal, Vol 43, Iss 1, Pp 32-43 (2020)
Background: CDGSH iron sulfur domain-containing protein 1 (CISD-1) belongs to the CISD protein family that is evolutionary conserved across different species. In mammals, CISD-1 protein has been implicated in diseases such as cancers and diabetes. As
Externí odkaz:
https://doaj.org/article/9dbf6b10f04c4f688e0b229b07e10cbc
Autor:
Chi-Chin Sun, Shao-Yun Lee, Cheng-Heng Kao, Li-Hsien Chen, Zhao-Qing Shen, Chia-Hui Lai, Tsai-Yu Tzeng, Jong-Hwei Su Pang, Wen-Tai Chiu, Ting-Fen Tsai
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103654- (2021)
Background: Age-related changes affecting the ocular surface cause vision loss in the elderly. Cisd2 deficiency drives premature aging in mice as well as resulting in various ocular surface abnormalities. Here we investigate the role of CISD2 in corn
Externí odkaz:
https://doaj.org/article/78376f21572c42f4975d2649ef8f3641
Autor:
Chi-Hsiao Yeh, Yi-Ju Chou, Tsung-Hsien Tsai, Paul Wei-Che Hsu, Chun-Hsien Li, Yun-Hsuan Chan, Shih-Feng Tsai, Soh-Ching Ng, Kuei-Mei Chou, Yu-Ching Lin, Yu-Hsiang Juan, Tieh-Cheng Fu, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 116 (2022)
An increased risk of cardiovascular events was identified in patients with peripheral artery disease (PAD). Clopidogrel is one of the most widely used antiplatelet medications. However, there are heterogeneous outcomes when clopidogrel is used to pre
Externí odkaz:
https://doaj.org/article/ab0fbb6b97f64d179adcaa24ad358c34
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1635 (2021)
With an increased life expectancy among humans, aging has recently emerged as a major focus in biomedical research. The lack of in vitro aging models—especially for neurological disorders, where access to human brain tissues is limited—has hamper
Externí odkaz:
https://doaj.org/article/176669d699564ff39946f69f3f715455