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pro vyhledávání: '"Tine Thone"'
Autor:
Werner Embrechts, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Serge Pieters, Vineet Pande, Geert Pille, Katie Amssoms, Ilham Smyej, Deborah Dhuyvetter, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thone, Dorien De Pooter, Gregory Fanning, Tim H. M. Jonckers, Helen Horton, Pierre Raboisson, David McGowan
Publikováno v:
Journal of Medicinal Chemistry. 61:6236-6246
A novel series of 2,4-diaminoquinazolines was identified as potent dual Toll-like receptor (TLR) 7 and 8 agonists with reduced off-target activity. The stereochemistry of the amino alcohol was found to influence the TLR7/8 selectivity with the ( R) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a3b7db1da80bbf55cd9acce1f8bb47
https://doi.org/10.1021/acs.jmedchem.8b00643
https://doi.org/10.1021/acs.jmedchem.8b00643
