Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tine Thoné"'
Autor:
Mari Luz Rosauro, Kris Van Dijck, Gregory Fanning, David McGowan, Sara M. Pérez Benedicto, Bart Stoops, Pierre Jean-Marie Bernard Raboisson, Bertrand Van Schoubroeck, Wendy Mostmans, Annick Scholliers, Tine Thoné, Frederik Pauwels, Mourad Daoubi Khamlichi, Vineet Pande, Tim H. M. Jonckers, Florence Herschke, Helen Horton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3216-3221
In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure-activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672c8e93b24a0e8e1a7a0d8161208345
https://doi.org/10.1016/j.bmcl.2018.08.015
https://doi.org/10.1016/j.bmcl.2018.08.015
Autor:
Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Werner Embrechts, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thoné, Dorien De Pooter, Gregory Fanning, Mari Luz Rosauro, Mourad Daoubi Khamlichi, Ioannis Houpis, Eric Arnoult, Tim H.M. Jonckers, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:711-719
The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb247545d952c5e2d61547d1061dea6
https://doi.org/10.1016/j.bmcl.2018.01.014
https://doi.org/10.1016/j.bmcl.2018.01.014
Autor:
David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Serge Pieters, Annick Scholliers, Tine Thoné, Bertrand Van Schoubroeck, Dorien De Pooter, Wendy Mostmans, Mourad Daoubi Khamlichi, Werner Embrechts, Deborah Dhuyvetter, Ilham Smyej, Eric Arnoult, Samuël Demin, Herman Borghys, Gregory Fanning, Jaromir Vlach, Pierre Raboisson
Publikováno v:
Journal of medicinal chemistry. 59(17)
Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcdde8057c6d45e0f5c5a8697064288
https://pubmed.ncbi.nlm.nih.gov/27513093
https://pubmed.ncbi.nlm.nih.gov/27513093