Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tine N. Vinther"'
Autor:
Tine N Vinther, Mathias Norrman, Holger M Strauss, Kasper Huus, Morten Schlein, Thomas Å Pedersen, Thomas Kjeldsen, Knud J Jensen, František Hubálek
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30882 (2012)
An ingenious system evolved to facilitate insulin binding to the insulin receptor as a monomer and at the same time ensure sufficient stability of insulin during storage. Insulin dimer is the cornerstone of this system. Insulin dimer is relatively we
Externí odkaz:
https://doaj.org/article/56be5fcb4f9d42f782c421c1d91bc207
Autor:
Trine R. Clausen, Marika Ejby Reinau, Ulrich Sensfuss, Kasper Huus, Henriette Kold Uldam, Tine N. Vinther, Susanne Schéele, Rikke Bjerring Skyggebjerg, Thomas Kruse, Bill Vestergaard
Publikováno v:
Journal of medicinal chemistry. 62(3)
A group of peptide-based, long-acting, stable, highly selective cholecystokinin 1 receptor (CCK-1R) agonists with the potential to treat obesity has been identified and characterized, based on systematic investigation of synthetic CCK-8 analogues wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6288d769777ecb3a872df748389c468e
https://pubmed.ncbi.nlm.nih.gov/30624060
https://pubmed.ncbi.nlm.nih.gov/30624060
Publikováno v:
Journal of Peptide Science. 21:797-806
Insulin, a small peptide hormone, is crucial in maintaining blood glucose homeostasis. The stability and activity of the protein is directed by an intricate system involving disulfide bonds to stabilize the active monomeric species and by their non-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e47352d83c6e27d6d5aa0bdae41ce6f
https://doi.org/10.1002/psc.2822
https://doi.org/10.1002/psc.2822
Autor:
Knud J. Jensen, Morten Schlein, Anders S. Sørensen, Ingrid Pettersson, Kasper Huus, Tine N. Vinther, Thomas Kjeldsen, Frantisek Hubalek, Dorte Bjerre Steensgaard
Publikováno v:
Protein Science. 24:779-788
The structure of insulin, a glucose homeostasis-controlling hormone, is highly conserved in all vertebrates and stabilized by three disulfide bonds. Recently, we designed a novel insulin analogue containing a fourth disulfide bond located between pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f46b57fab82ced83f61f3ab2c76a5c0
https://doi.org/10.1002/pro.2649
https://doi.org/10.1002/pro.2649
Autor:
Knud J. Jensen, Ulla Ribel, Morten Schlein, Thomas Åskov Pedersen, Ingrid Pettersson, Svend Ludvigsen, Kasper Huus, Mathias Norrman, Tine N. Vinther, Thomas Kjeldsen, Frantisek Hubalek, Dorte Bjerre Steensgaard
Publikováno v:
Protein Science. 22:296-305
Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7f79cf205328b66ca4506dd399f8840
https://doi.org/10.1002/pro.2211
https://doi.org/10.1002/pro.2211
Autor:
Tine N. Vinther, Thomas Kjeldsen, Thomas Åskov Pedersen, Ulla Ribel, Knud J. Jensen, Frantisek Hubalek
Publikováno v:
ChemBioChem. 12:2448-2455
Chemical modifications of proteins are increasingly important in the development of protein drugs with fine-tuned properties. Regioselective modification, such as the chemoselective alkylation of an unpaired cysteine residue, is a prerequisite for ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c1d9f9aebdd862fb6fa181cb7f316d
https://doi.org/10.1002/cbic.201100464
https://doi.org/10.1002/cbic.201100464
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 21(11)
Insulin, a small peptide hormone, is crucial in maintaining blood glucose homeostasis. The stability and activity of the protein is directed by an intricate system involving disulfide bonds to stabilize the active monomeric species and by their non-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79b836e8d73f3bb510fd5835e41a93ca
https://pubmed.ncbi.nlm.nih.gov/26382042
https://pubmed.ncbi.nlm.nih.gov/26382042
Autor:
Tine N, Vinther, Mathias, Norrman, Ulla, Ribel, Kasper, Huus, Morten, Schlein, Dorte B, Steensgaard, Thomas Å, Pedersen, Ingrid, Pettersson, Svend, Ludvigsen, Thomas, Kjeldsen, Knud J, Jensen, František, Hubálek
Publikováno v:
Protein science : a publication of the Protein Society. 22(3)
Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd6bec06fb7a4f24d6310e0381a742c6
https://pubmed.ncbi.nlm.nih.gov/23281053
https://pubmed.ncbi.nlm.nih.gov/23281053
Autor:
Ulla Ribel, Frantisek Hubalek, Tine N. Vinther, Knud J. Jensen, Thomas Kjeldsen, Thomas Åskov Pedersen
Publikováno v:
ChemBioChem. 12:2378-2378
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa27dabb36aad3bf506b3b9ff0c56e0
https://doi.org/10.1002/cbic.201190075
https://doi.org/10.1002/cbic.201190075