Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected

Autor: Liselotte Bruun Christiansen, Tine Lovsø Dohlmann, Trine Pagh Ludvigsen, Ewa Parfieniuk, Michal Ciborowski, Lukasz Szczerbinski, Adam Kretowski, Claus Desler, Luca Tiano, Patrick Orlando, Torben Martinussen, Lisbeth Høier Olsen, Steen Larsen

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Statins lower the risk of cardiovascular events but have been associated with mitochondrial functional changes in a tissue-dependent manner. We investigated tissue-specific modifications of mitochondrial function in liver, heart and skeletal

Externí odkaz: https://doaj.org/article/464bb8e1326e4d41b93a471fef364086

Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected

Autor: Lisbeth H. Olsen, Steen Larsen, Patrick Orlando, Michal Ciborowski, Torben Martinussen, Claus Desler, Tine Lovsø Dohlmann, Trine Pagh Ludvigsen, Lukasz Szczerbinski, Luca Tiano, Liselotte B Christiansen, Adam Kretowski, Ewa Parfieniuk

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Christiansen, L B, Dohlmann, T L, Ludvigsen, T P, Parfieniuk, E, Ciborowski, M, Szczerbinski, L, Kretowski, A, Desler, C, Tiano, L, Orlando, P, Martinussen, T, Olsen, L H & Larsen, S 2021, ' Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected ', Scientific Reports, vol. 11, 2167 . https://doi.org/10.1038/s41598-021-81846-9
Scientific Reports

Statins lower the risk of cardiovascular events but have been associated with mitochondrial functional changes in a tissue-dependent manner. We investigated tissue-specific modifications of mitochondrial function in liver, heart and skeletal muscle m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6164af5438a7c7bda42aca951062204e
https://doaj.org/article/464bb8e1326e4d41b93a471fef364086

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Autor: Jeppe Kjærgaard Larsen, Magnus R. Larsen, Jørgen F. P. Wojtaszewski, Joachim Fentz, Peter Schjerling, Henriette Pilegaard, Benoit Viollet, Steen Larsen, Christian Frøsig, Andreas M. Fritzen, Peter Overby, Jens Frey Halling, Stephanie Holm, Tine Lovsø Dohlmann, Rasmus Kjøbsted, Jesper B. Birk, Kohei Kido, Nicolas O. Jørgensen, Marc Foretz, Janne R. Hingst, Sasha A.S. Kjeldsen, Ylva Hellsten

Publikováno v: Molecular Metabolism, Vol 40, Iss, Pp 101028-(2020)
Molecular Metabolism

Objective Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8038a3d242e58e10654753efaca0f30d
http://www.sciencedirect.com/science/article/pii/S2212877820301022

The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study

Autor: Jørn Wulff Helge, Nis Stride, Magnus Asping, Tine Lovsø Dohlmann, Flemming Dela, Ditte Søgaard, Steen Larsen

Publikováno v: European Journal of Clinical Pharmacology. 73:679-687

Statins are used to lower cholesterol in plasma and are one of the most used drugs in the world. Many statin users experience muscle pain, but the mechanisms are unknown at the moment. Many studies have hypothesized that mitochondrial function could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe7bd1694f84f0ad273cc1e48b5f80d
https://doi.org/10.1007/s00228-017-2224-4

LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction

Autor: Steen Larsen, Anja Birk Kuhlman, John Sahl Andersen, Maria Nathalie Angleys Olsen, Ian D. Hickson, Bjarke Oxlund, A. Heltberg, Sofie Rosenlund Lau, Thomas Morville, Kasper Bering Liisberg, Birgitte Bruun, Margit Kriegbaum, Tine Lovsø Dohlmann, Christa Lykke Christensen, Flemming Dela, Jørn Wulff Helge, Allan Krasnik, Lene Juel Rasmussen

Publikováno v: Christensen, C L, Helge, J W, Krasnik, A, Kriegbaum, M, Rasmussen, L J, Hickson, I D, Liisberg, K B, Oxlund, B, Bruun, B, Lau, S R, Olsen, M N A, Andersen, J S, Heltberg, A S, Kuhlman, A C B, Morville, T H, Dohlmann, T L, Larsen, S & Dela, F 2016, ' LIFESTAT – Living with statins : An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction ', Scandinavian Journal of Public Health, vol. 44, no. 5, pp. 534-539 . https://doi.org/10.1177/1403494816636304

AIM:LIFESTAT is an interdisciplinary project that leverages approaches and knowledge from medicine, the humanities and the social sciences to analyze the impact of statin use on health, lifestyle and well-being in cohorts of Danish citizens. The impe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dc33b034186afe9f647024013b8f17
https://doi.org/10.1177/1403494816636304