Genome-wide Analysis of CDX2 Binding in Intestinal Epithelial Cells (Caco-2)

Autor: Mads Bak, Anders Krüger Olsen, Lotte L. Bram, Mette Boyd, Jørgen Olsen, Morten Hartvig Hansen, Niels Tommerup, Jesper T. Troelsen, Anna Perearnau, Tine G.K. Jensen

Publikováno v: Journal of Biological Chemistry. 285:25115-25125

The CDX2 transcription factor is known to play a crucial role in inhibiting proliferation, promoting differentiation and the expression of intestinal specific genes in intestinal cells. The overall effect of CDX2 in intestinal cells has previously be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e268d0bd33d6b62533b09f1d54403d7d
https://doi.org/10.1074/jbc.m109.089516

Independent introduction of two lactase-persistence alleles into humanpopulations reflects different history of adaptation to milk culture

Autor: Jeong Kee Seo, Insaf F. Khalil, Leif Groop, Hatem El-Shanti, Faiqa Imtiaz, Else Marie Vestergaard, Abdrazak Natah, Mikko Kuokkanen, Heli Rasinperä, Sirajedin S. Natah, David Comas, Brian F. Meyer, Mette Olaf Nielsen, S. Qasim Mehdi, Rikke Lewinski, Mohamed S. Rashed, Nabil Enattah, Tine G.K. Jensen, Michael Alifrangis, Jesper T. Troelsen, Leena Peltonen, Ahmed Ali

Publikováno v: Enattah, NS, Jensen, TG, Nielsen, M, Lewinski, R, Kuokkanen, M, Rasinpera, H, El-Shanti, H, Seo, JK, Alifrangis, M, Khalil, IF, Natah, A, Ali, A, Natah, S, Comas, D, Mehdi, SQ, Groop, L, Vestergaard, E M, Imtiaz, F, Rashed, MS, Meyer, B, Troelsen, J & Peltonen, L 2008, ' Independent introduction of two lactase-persistence alleles into humanpopulations reflects different history of adaptation to milk culture ', American Journal of Human Genetics, vol. 82, no. 1, pp. 57-72 . https://doi.org/10.1016/j.ajhg.2007.09.012

Udgivelsesdato: jan The T(-13910) variant located in the enhancer element of the lactase (LCT) gene correlates perfectly with lactase persistence (LP) in Eurasian populations whereas the variant is almost nonexistent among Sub-Saharan African populat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c3b03e1d3631a071aec67888c21290
https://pure.au.dk/portal/da/publications/independent-introduction-of-two-lactasepersistence-alleles-into-humanpopulations-reflects-different-history-of-adaptation-to-milk-culture(55a85440-c6b8-11dd-9710-000ea68e967b).html

T-13910 DNA variant associated with lactase persistence interacts With Oct-1 and stimulates lactase promoter activity in vitro

Autor: Jørgen Olsen, Jesper T. Troelsen, Jette Møller, Tine G.K. Jensen, Allan Stensballe, Rikke H. Lewinsky

Publikováno v: University of Copenhagen
Aalborg University
Lewinsky, R H, Jensen, T G K, Møller, J, Stensballe, A, Olsen, J & Troelsen, J T 2005, ' T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro ', Human Molecular Genetics, vol. 14, no. 24, pp. 3945-53 .

Two phenotypes exist in the human population with regard to expression of lactase in adults. Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized by a decline in the expression of lactase-phlorizin hydrolase (LPH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57b25238cbcc1ebf74d980571e2f6d6
https://curis.ku.dk/portal/en/publications/t13910-dna-variant-associated-with-lactase-persistence-interacts-with-oct1-and-stimulates-lactase-promoter-activity-in-vitro(364b17d0-74c2-11db-bee9-02004c4f4f50).html