Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tine Decruy"'
Autor:
Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cel
Externí odkaz:
https://doaj.org/article/ddd72678135941fdb84362715749b1f1
Autor:
Joke Deprez, Silke Roovers, Guillaume Lajoinie, Heleen Dewitte, Tine Decruy, Julie Coudenys, Benedicte Descamps, Christian Vanhove, Michel Versluis, Dirk Elewaut, Peggy Jacques, Stefaan C. De Smedt, Ine Lentacker
Publikováno v:
Scientia Pharmaceutica, Vol 90, Iss 1, p 17 (2022)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by severe inflammation of the synovial tissue. Here, we assess the feasibility of liposome-loaded microbubbles as theranostic agents in a murine arthritis model. First, contrast-enhance
Externí odkaz:
https://doaj.org/article/9847d7cc916e43a9a3f03ff3b7aa744c
Autor:
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we presen
Externí odkaz:
https://doaj.org/article/b6242e5fce344e1e9535e44bda9ee7ff
Autor:
Céline Mortier, Eric Gracey, Julie Coudenys, Teddy Manuello, Tine Decruy, Margaux Maelegheer, Flore Stappers, Elisabeth Gilis, Djoere Gaublomme, Luc Van Hoorebeke, Sophie Van Welden, Catherine Ambler, Martin Hegen, Peter Symanowicz, Stefan Steyn, Gabriel Berstein, Dirk Elewaut, Koen Venken
Publikováno v:
Rheumatology.
Objective Divergent therapeutic outcomes on different disease domains have been noted with IL-23 and IL-17A-blockade in PsA. Therefore, elucidating the role of RORγt, the master regulator of type 17 immune responses, is of potential therapeutic inte
Autor:
Koen Venken, Matthias Jarlborg, Tine Decruy, Céline Mortier, Carolien Vlieghe, Elisabeth Gilis, Ann-Sophie De Craemer, Julie Coudenys, Isabelle Cambré, Devan Fleury, Alexander Klimowicz, Filip Van den Bosch, Anne Hoorens, Triana Lobaton, Sytze de Roock, Tim Sparwasser, Gerald Nabozny, Peggy Jacques, Dirk Elewaut
Publikováno v:
ANNALS OF THE RHEUMATIC DISEASES
ObjectivesGut and joint inflammation commonly co-occur in spondyloarthritis (SpA) which strongly restricts therapeutic modalities. The immunobiology underlying differences between gut and joint immune regulation, however, is poorly understood. We the
Autor:
Elisabeth Gilis, Tine Decruy, Koen Venken, Rudi Beyaert, Amélie De Muynck, Jens Staal, Julie Coudenys, Nadia Schryvers, Annelies Demeyer, Jolanda van Hengel, Maarten Dhaenens, Luc Van Hoorebeke, Stijn Lambrecht, Dirk Elewaut, Emilie Dumas, Djoere Gaublomme, Yasmine Driege, Dieter Deforce
Publikováno v:
Arthritis & Rheumatology. 71:2005-2015
Objective: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1) plays a crucial role in innate and adaptive immune signaling by modulating the threshold for activation of immune cells, including Treg cells. Therefore, MALT-1 is
Autor:
Dirk M. Zajonc, Soumya G. Remesh, Serge Van Calenbergh, Tine Decruy, Jonas Janssens, Mathy Froeyen, Martijn D. P. Risseeuw, Dirk Elewaut, Joren Guillaume, Jing Wang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
SCIENTIFIC REPORTS
Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synth
Autor:
Dirk Elewaut, Toshiyuki Seki, Tine Decruy, Johan Van der Eycken, Moriya Tsuji, Koen Venken, Serge Van Calenbergh, Simon Krols, Jonas Janssens
Publikováno v:
ACS MEDICINAL CHEMISTRY LETTERS
A synthesis strategy for the swift generation of 4"-modified alpha-galactosylceramide (alpha-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure activity relationships (SAR) of this understudi
Autor:
J. Van der Eycken, Tine Decruy, Dirk Elewaut, S. Van Calenbergh, Jonas Janssens, Jing Wang, Dirk M. Zajonc, Koen Venken, Aruna Bitra
Publikováno v:
ChemMedChem. 14(1)
Invariant natural killer T-cells (iNKT) are a glycolipid-responsive subset of T-lymphocytes that fulfill a pivotal role in the immune system. The archetypical synthetic glycolipid, alpha-galactosylceramide (alpha-GalCer), whose molecular framework is
Autor:
Dirk Elewaut, Toshiyuki Seki, Serge Van Calenbergh, Tine Decruy, Moriya Tsuji, Joren Guillaume, Koen Venken
Publikováno v:
Organicbiomolecular chemistry. 15(10)
α-GalCer analogues that combine known Th1 polarizing C6′′-modifications with a C-glycosidic linkage were synthesized. We employed a protecting group strategy that allowed the preparation of both saturated and unsaturated derivatives with variabl