Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tine Brouns"'
Publikováno v:
Cells, Vol 13, Iss 3, p 227 (2024)
The transcriptional co-activator lens epithelium-derived growth factor/p75 (LEDGF/p75) plays an important role in the biology of the cell and in several human diseases, including MLL-rearranged acute leukemia, autoimmunity, and HIV-1 infection. In bo
Externí odkaz:
https://doaj.org/article/5f1ec83871864e7ab48c3460f74818d4
Autor:
Willem Vanderlinden, Tine Brouns, Philipp U. Walker, Pauline J. Kolbeck, Lukas F. Milles, Wolfgang Ott, Philipp C. Nickels, Zeger Debyser, Jan Lipfert
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Retroviral integration of DNA into the host genome is a point of no return in the replication cycle but how efficient integration can take place remains unclear. Here the authors demonstrate that consecutive nucleoprotein intermediates are increasing
Externí odkaz:
https://doaj.org/article/ba3ac588e06f42a0baa99862c45b98ff
Force and torque spectroscopy have provided unprecedented insights into the mechanical properties, conformational transitions, and dynamics of DNA and DNA-protein complexes, notably nucleosomes. Reliable single-molecule manipulation measurements requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49e263f6c4d354db8feb9b93c3c4282
https://doi.org/10.1101/2023.01.05.522917
https://doi.org/10.1101/2023.01.05.522917
Autor:
Yi-Yun Lin1,2, Tine Brouns1,3, Kolbeck, Pauline J.1,2, Vanderlinden, Willem1,2 W.Vanderlinden@uu.nl, Lipfert, Jan1,2 J.Lipfert@uu.nl
Publikováno v:
Journal of Biological Chemistry. Jul2023, Vol. 299 Issue 7, p1-10. 10p.
Autor:
Zeger Debyser, Alessandro Canella, Giovanni Nigita, Frauke Christ, Siska Van Belle, Tine Brouns, Marianne Carlon
Publikováno v:
Cancer Gene Therapy. 29:133-140
MLL is an aggressive subtype of leukemia with a poor prognosis that mostly affects pediatric patients. MLL-rearranged fusion proteins (MLLr) induce aberrant target gene expression resulting in leukemogenesis. MLL and its fusions are tethered to chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13249a49a60ed52d41f4d8aa555ebfbf
https://doi.org/10.1038/s41417-021-00319-3
https://doi.org/10.1038/s41417-021-00319-3
Autor:
Kateřina Čermáková, Magdalena Hořejší, Zeger Debyser, Milan Fábry, Zdeněk Kukačka, Tine Brouns, Marcela Mádlíková, M. Kugler, Frauke Christ, Pavel Srb, Vaclav Veverka, Jan DeRijck, Jiří Brynda, Vanda Lux, Petr Novák
Publikováno v:
Structure
Dimerization of many eukaryotic transcription regulatory factors is critical for their function. Regulatory role of an epigenetic reader lens epithelium-derived growth factor/p75 (LEDGF/p75) requires at least two copies of this protein to overcome th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c02af025d8326252cb2ab25335eed45
https://lirias.kuleuven.be/handle/123456789/660608
https://lirias.kuleuven.be/handle/123456789/660608
Publikováno v:
Biophysical Journal. 118:375a-376a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8d4550e0e7e4724ac44e83daf70566
https://doi.org/10.1016/j.bpj.2019.11.2148
https://doi.org/10.1016/j.bpj.2019.11.2148
Autor:
Zeger Debyser, Philipp C. Nickels, Jan Lipfert, Lukas F. Milles, Willem Vanderlinden, Wolfgang Ott, Tine Brouns, Philipp U. Walker, Pauline J. Kolbeck
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Retroviral integration, the process of covalently inserting viral DNA into the host genome, is a point of no return in the replication cycle. Yet, strand transfer is intrinsically iso-energetic and it is not clear how efficient integration can be ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e534cc99b149b012ec2cc4f35d304b4
https://doi.org/10.1038/s41467-019-12649-w
https://doi.org/10.1038/s41467-019-12649-w
Publikováno v:
Acs Nano, 10(9), 8394-8402. AMER CHEMICAL SOC
Many important processes in biology involve the translocation of a biopolymer through a nanometer-scale pore. Moreover, the electrophoretic transport of DNA across nanoscale pores is under intense investigation for single-molecule DNA sequencing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb20d2f09c68cd768baef2bf4ae42ec
https://doi.org/10.1021/acsnano.6b03159
https://doi.org/10.1021/acsnano.6b03159
Autor:
Herlinde De Keersmaecker, Willem Vanderlinden, Jan Lipfert, Steven De Feyter, Toshio Ando, Noriyuki Kodera, Sebastian F. Konrad, Tine Brouns
Publikováno v:
ACS nano. 12(12)
DNA supercoiling fundamentally constrains and regulates the storage and use of genetic information. While the equilibrium properties of supercoiled DNA are relatively well understood, the dynamics of supercoils are much harder to probe. Here we use a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5948de6a636490086ea58d2a1f695e7c
https://pubmed.ncbi.nlm.nih.gov/30346700
https://pubmed.ncbi.nlm.nih.gov/30346700