T cell responses to SARS-1 CoV-2 spike cross-recognize Omicron

Autor: Keeton, R, Tincho, MB, Ngomti, A, Baguma, R, Benede, N, Suzuki, A, Khan, K, Madzorerera, SV, Moyo-Gwete, T, Mennen, M, SKelem, S, Adriaanse, M, Muthithu, D, Aremu, O, Stek, C, Du Bruyn, E, Van Der Mescht, MA, De Beer, Z, De Villiers, TR, Bodenstein, A, Van der Berg, G, Mendes, A, Strydom, A, Venter, M, Giandhari, J, Naidoo, Y, Pillay, S, Tegally, H, Grifoni, A, Weiskopf, D, Sette, A, Wilkinson, RJ, De Oliveira, T, Bekker, L-G, Gray, G, Ueckermann, V, Rossouw, T, Boswell, MT, Bihman, F, Moore, PL, Ntusi, NN, Burgers, WA, Riou, C

The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations1,2 that contribute to escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other components of the adaptive response such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::8027487aaa08530c0ca18cc29a2881c0
http://hdl.handle.net/10044/1/94062

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection.

Autor: Moyo-Gwete T; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Richardson SI; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Keeton R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa., Hermanus T; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Spencer H; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Manamela NP; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Ayres F; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Makhado Z; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Motlou T; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Tincho MB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa., Benede N; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa., Ngomti A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa., Baguma R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa., Chauke MV; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa., Mennen M; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa.; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa., Adriaanse M; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa.; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa., Skelem S; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa.; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa., Goga A; South African Medical Research Council, Cape Town, South Africa., Garrett N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Discipline of Public Health Medicine, University of KwaZulu-Natal, Durban, South Africa., Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Desmond Tutu HIV Centre, Cape Town, South Africa., Gray G; South African Medical Research Council, Cape Town, South Africa., Ntusi NAB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, South Africa.; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa., Riou C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Division of Medical Virology, Department of Pathology; University of Cape Town; Observatory, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa., Moore PL; SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Nov 09; Vol. 19 (11), pp. e1011772. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).

Impact of SARS-CoV-2 exposure history on the T cell and IgG response.

Autor: Keeton R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Tincho MB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Suzuki A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Benede N; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Ngomti A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Baguma R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Chauke MV; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Mennen M; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa., Skelem S; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa., Adriaanse M; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA., Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Gray G; South African Medical Research Council, Cape Town, South Africa., Ntusi NAB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Extramural Unit on Intersection of Non-communicable Diseases and Infectious Diseases, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa. Electronic address: wendy.burgers@uct.ac.za., Riou C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa. Electronic address: cr.riou@uct.ac.za.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Jan 17; Vol. 4 (1), pp. 100898. Date of Electronic Publication: 2022 Dec 22.

Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron.

Autor: Keeton R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Tincho MB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Ngomti A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Baguma R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Benede N; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Suzuki A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Bernstein M; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Madzorera SV; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mennen M; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Skelem S; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Adriaanse M; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Mutithu D; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Aremu O; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Stek C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., du Bruyn E; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Van Der Mescht MA; Department of Immunology, University of Pretoria, Pretoria, South Africa., de Beer Z; Tshwane District Hospital, Tshwane, South Africa., de Villiers TR; Tshwane District Hospital, Tshwane, South Africa., Bodenstein A; Tshwane District Hospital, Tshwane, South Africa., van den Berg G; Tshwane District Hospital, Tshwane, South Africa., Mendes A; Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa., Strydom A; Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa., Venter M; Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Naidoo Y; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Pillay S; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA., Wilkinson RJ; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Infectious Diseases, Imperial College London, London, UK.; The Francis Crick Institute, London, UK., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.; Centre for Epidemic Response and Innovation, Stellenbosch University, Stellenbosch, South Africa., Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Gray G; South African Medical Research Council, Cape Town, South Africa., Ueckermann V; Department of Internal Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa., Rossouw T; Department of Immunology, University of Pretoria, Pretoria, South Africa., Boswell MT; Department of Internal Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa., Bhiman JN; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Moore PL; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany., Ntusi NAB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, Cape Town, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa. wendy.burgers@uct.ac.za.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa. wendy.burgers@uct.ac.za.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa. wendy.burgers@uct.ac.za., Riou C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa. cr.riou@uct.ac.za.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa. cr.riou@uct.ac.za.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa. cr.riou@uct.ac.za.

Publikováno v: Nature [Nature] 2022 Apr; Vol. 604 (7907), pp. E25.

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity.

Autor: Riou C; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Keeton R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Hermanus T; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kgagudi P; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Baguma R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Valley-Omar Z; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Smith M; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Doolabh D; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Iranzadeh A; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Tyers L; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Mutavhatsindi H; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa., Tincho MB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Benede N; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Marais G; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa.; Groote Schuur Hospital Medical Virology Laboratory of the National Health Laboratory Service, Observatory 7925, South Africa., Chinhoyi LR; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., Mennen M; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., Skelem S; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., du Bruyn E; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa., Stek C; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Department of Infectious Diseases, Imperial College London, London W12 0NN, UK., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Williamson C; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa., Moore PL; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Wilkinson RJ; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Department of Infectious Diseases, Imperial College London, London W12 0NN, UK.; The Francis Crick Institute, London NW1 1AT, UK., Ntusi NAB; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa.; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa., Burgers WA; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory 7925, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town, Observatory 7925, South Africa.

Publikováno v: Science translational medicine [Sci Transl Med] 2022 Feb 09; Vol. 14 (631), pp. eabj6824. Date of Electronic Publication: 2022 Feb 09.