Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tinamarie Skedzielewski"'
Autor:
Hasan Alsaid, Tinamarie Skedzielewski, Mary V Rambo, Kristen Hunsinger, Bao Hoang, William Fieles, Edward R Long, James Tunstead, Danielle J Vugts, Matthew Cleveland, Neil Clarke, Christopher Matheny, Beat M Jucker
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176075 (2017)
The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced 'AccretaMab' monoclonal antibody) pharmacokinetics and pharmacodynamics in human xenograft tumor-bearing mic
Externí odkaz:
https://doaj.org/article/8a2ccc9895534f1ca10fbfa2c7a01728
Autor:
Shih-Hsun Cheng, M. Reid Groseclose, Cindy Mininger, Mats Bergstrom, Lily Zhang, Stephen C. Lenhard, Tinamarie Skedzielewski, Zachary D. Kelley, Debra Comroe, Hyundae Hong, Haifeng Cui, Jennifer L. Hoover, Steve Rittenhouse, Stephen Castellino, Beat M. Jucker, Hasan Alsaid
Publikováno v:
Journal of Controlled Release. 352:199-210
Liposomes are promising targeted drug delivery systems with the potential to improve the efficacy and safety profile of certain classes of drugs. Though attractive, there are unique analytical challenges associated with the development of liposomal d
Autor:
Hasan Alsaid, Shih-Hsun Cheng, Meixia Bi, Fang Xie, Mary Rambo, Tinamarie Skedzielewski, Bao Hoang, Sunish Mohanan, Debra Comroe, Andrew Gehman, Chih-Yang Hsu, Kamyar Farhangi, Hoang Tran, Valeriia Sherina, Minh Doan, M. Reid Groseclose, Christopher B. Hopson, Sara Brett, Ian A. Wilson, Andrew Nicholls, Marc Ballas, Jeremy D. Waight, Beat M. Jucker
Publikováno v:
Molecular Imaging and Biology. 25:528-540
Purpose The presence and functional competence of intratumoral CD8+ T cells is often a barometer for successful immunotherapeutic responses in cancer. Despite this understanding and the extensive number of clinical-stage immunotherapies focused on po
Autor:
Tolulope A. Aweda, Shih-Hsun Cheng, Stephen C. Lenhard, Armin Sepp, Tinamarie Skedzielewski, Chih-Yang Hsu, Shelly Marshall, Heather Haag, Jonathan Kehler, Prabhas Jagdale, Alessia Peter, Michael A. Schmid, Andrew Gehman, Minh Doan, Andrew P. Mayer, Peter Gorycki, Marie Fanget, Christophe Colas, Brenda Smith, Curtis C. Maier, Hasan Alsaid
Publikováno v:
European journal of nuclear medicine and molecular imaging.
Purpose Sotrovimab (VIR-7831), a human IgG1κ monoclonal antibody (mAb), binds to a conserved epitope on the SARS-CoV-2 spike protein receptor binding domain (RBD). The Fc region of VIR-7831 contains an LS modification to promote neonatal Fc receptor
Autor:
Mark Reid Groseclose, Jeremy Barry, Tinamarie Skedzielewski, Gerald McDermott, Chakravarthi Balabhadrapatruni, Bill Benson, Yongle Pang, David K. Lim, Hoang Tran, Mike Ringenberg, Keyur Gada, Amine Aziez, Elaine Paul, Hasan Alsaid
Publikováno v:
Cancer Research. 83:3582-3582
Purpose: There remains an unmet need to provide effective treatment therapy for patients with primary and metastatic brain tumors; lack of drug penetration across the blood brain barrier (BBB) is a key factor. Synthetic lethality remains an attractiv
Autor:
Shih-Hsun Cheng, Reid Groseclose, Cindy Mininger, Mats Bergstrom, Lily Zhang, Steve C. Lenhard, Tinamarie Skedzielewski, Debra Comroe, Hyundae Hong, Haifeng Cui, Jennifer L. Hoover, Steve Rittenhouse, Stephen Castellino, Beat M. Jucker, Hasan Alsaid
Liposomes are promising targeted drug delivery systems with the potential to improve the efficacy and safety profile of certain classes of drugs. Though attractive, there are unique analytical challenges associated with the development of liposomal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82667fb7fe71b9e81cdf899bcb1d908e
https://doi.org/10.21203/rs.3.rs-1479300/v1
https://doi.org/10.21203/rs.3.rs-1479300/v1
Autor:
Howard M. Solomon, Joyce Rendemonti, Tinamarie Skedzielewski, Beat M. Jucker, Dinesh Stanislaus, Stacia F Murzyn, Hasan Alsaid, Sharon P Chapman
Publikováno v:
Birth Defects Research. 110:276-298
Objectives In our laboratory we evaluated the use of micro-computed tomography (micro-CT) using a high resolution acquisition protocol and fetuses obtained on Gestation Day (GD) 29 (mating = GD 0). Methods To show concordance between traditional Aliz
Autor:
Chih-Yang Hsu, Fang Xie, Sunish Mohanan, Sara Brett, Axel Hoos, Bao Hoang, Tinamarie Skedzielewski, Jeremy D. Waight, Hasan Alsaid, Meixia Bi, Minh Doan, M. Reid Groseclose, Andrew Gehman, Shih-Hsun Cheng, Mary V. Rambo, Marc S. Ballas, Christopher B. Hopson, Andrew Nicholls, Ian A. Wilson, Beat M. Jucker
Publikováno v:
Cancer Research. 81:2816-2816
Introduction Inducible T cell co-stimulator (ICOS) is a co-stimulatory receptor that is important for promoting immune activation and function. Despite reported clinical activity and a wide range of non-clinical studies supporting a role for ICOS in
Autor:
Danielle J. Vugts, Mary V. Rambo, Matthew Cleveland, Bao Hoang, Hasan Alsaid, Edward Long, Tinamarie Skedzielewski, James Tunstead, Neil J. Clarke, Kristen Hunsinger, William E. Fieles, Beat M. Jucker, Christopher Matheny
Publikováno v:
PLoS ONE, 12(4). Public Library of Science
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0176075 (2017)
Alsaid, H, Skedzielewski, T, Rambo, M V, Hunsinger, K, Hoang, B, Fieles, W, Long, E R, Tunstead, J, Vugts, D J, Cleveland, M, Clarke, N, Matheny, C & Jucker, B M 2017, ' Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice ', PLoS ONE, vol. 12, no. 4, pp. e0176075 . https://doi.org/10.1371/journal.pone.0176075
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0176075 (2017)
Alsaid, H, Skedzielewski, T, Rambo, M V, Hunsinger, K, Hoang, B, Fieles, W, Long, E R, Tunstead, J, Vugts, D J, Cleveland, M, Clarke, N, Matheny, C & Jucker, B M 2017, ' Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice ', PLoS ONE, vol. 12, no. 4, pp. e0176075 . https://doi.org/10.1371/journal.pone.0176075
The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced 'AccretaMab' monoclonal antibody) pharmacokinetics and pharmacodynamics in human xenograft tumor-bearing mic