Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tinalyn Kupfer"'
Autor:
Ghanashyam Sarikonda, Sowbarnika Sachithanantham, Yulia Manenkova, Tinalyn Kupfer, Amanda Posgai, Clive Wasserfall, Philip Bernstein, Laura Straub, Philippe P Pagni, Darius Schneider, Teresa Rodriguez Calvo, Marilyne Coulombe, Kevan Herold, Ronald G Gill, Mark Atkinson, Gerald Nepom, Mario Ehlers, Teodora Staeva, Hideki Garren, Lawrence Steinman, Andrew C Chan, Matthias von Herrath
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54712 (2013)
A recent type 1 diabetes (T1D) clinical trial of rituximab (a B cell-depleting anti-CD20 antibody) achieved some therapeutic benefit in preserving C-peptide for a period of approximately nine months in patients with recently diagnosed diabetes. Our p
Externí odkaz:
https://doaj.org/article/de59e6efcbf84a03a25062ac99797d76
Autor:
Philip Bernstein, Matthias von Herrath, Clive Wasserfall, Teodora Staeva, Philippe P. Pagni, Yulia Manenkova, Kevan C. Herold, Laura Straub, Mario R. Ehlers, Amira Bel Hani, Amanda L. Posgai, Ronald G. Gill, Tinalyn Kupfer, Songyan Deng, Mark A. Atkinson, Gerald T. Nepom
Publikováno v:
Diabetes. 65:1310-1316
There is an ongoing need to develop strategic combinations of therapeutic agents to prevent type 1 diabetes (T1D) or to preserve islet β-cell mass in new-onset disease. Although clinical trials using candidate therapeutics are commonly based on prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36411722484d0435d1b96d38ac175e3
https://doi.org/10.2337/db15-0492
https://doi.org/10.2337/db15-0492
Autor:
Michelle Nelsen, K. Scott Beard, B.A. Pietra, Ronald G. Gill, Todd J. Grazia, Tinalyn Kupfer, Robert J. Plenter, Martin R. Zamora, Marilyne Coulombe, C.M. Lin
The induction of tolerance to transplanted organs is a major objective in transplantation immunology research. Lymphocyte function-associated antigen-1 (LFA-1) interactions have been identified as a key component of the T-cell activation process that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76091600a735b10707bd498b06d3e824
https://europepmc.org/articles/PMC6174680/
https://europepmc.org/articles/PMC6174680/
Autor:
Lawrence Steinman, Sowbarnika Sachithanantham, Mark A. Atkinson, Marilyne Coulombe, Hideki Garren, Ghanashyam Sarikonda, Mario R. Ehlers, Yulia Manenkova, Teodora Staeva, Philip Bernstein, Gerald T. Nepom, Teresa Rodriguez Calvo, Darius A. Schneider, Clive Wasserfall, Ronald G. Gill, Tinalyn Kupfer, Kevan C. Herold, Andrew C. Chan, Philippe P. Pagni, Matthias von Herrath, Laura Straub, Amanda L. Posgai
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54712 (2013)
PLoS ONE
PLoS ONE
A recent type 1 diabetes (T1D) clinical trial of rituximab (a B cell-depleting anti-CD20 antibody) achieved some therapeutic benefit in preserving C-peptide for a period of approximately nine months in patients with recently diagnosed diabetes. Our p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49181466fb83861299602a37ecba497
http://europepmc.org/articles/PMC3566105?pdf=render
http://europepmc.org/articles/PMC3566105?pdf=render
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(4)
When transplanted into type 1a diabetic recipients, islet allografts are subject both to conventional allograft immunity and, presumably, to recurrent autoimmune (islet-specific) pathogenesis. Importantly, CD4 T cells play a central role both in isle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fca8b9e850f8ca42e95a0d6c23aaef
https://pubmed.ncbi.nlm.nih.gov/16081800
https://pubmed.ncbi.nlm.nih.gov/16081800
Publikováno v:
The Journal of Immunology. 192:202.9-202.9
It is unclear whether autoimmune disease recurrence overlaps with allograft immunity in the autoimmune diabetic recipient of a pancreatic islet transplant. We grafted autoimmune NOD mice with either syngeneic NOD or allogeneic C57Bl/6 (B6) islets tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c098e146d28dbfd43e5da8989a2dc7b6
https://doi.org/10.4049/jimmunol.192.supp.202.9
https://doi.org/10.4049/jimmunol.192.supp.202.9
Publikováno v:
The Journal of Immunology. 192:202.10-202.10
NOD mice, a well-characterized model of type 1 diabetes, provide a stringent model in which to test transplant tolerance-promoting therapies. We studied the failure of T cell-directed therapies in the autoimmune recipient. When we blocked T cell co-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d1c2dda30cb1c518d5035415e1a570
https://doi.org/10.4049/jimmunol.192.supp.202.10
https://doi.org/10.4049/jimmunol.192.supp.202.10
Publikováno v:
Transplantation Proceedings. 40:462-463
Islet allografts are destroyed rapidly in spontaneously diabetic nonobese diabetic (NOD) mice. However, whether this process is more similar to conventional allograft immunity, islet-specific autoimmune pathogenesis, or both remains controversial. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006502e38679f2b4ced0de5efa95565e
https://doi.org/10.1016/j.transproceed.2008.01.054
https://doi.org/10.1016/j.transproceed.2008.01.054
Publikováno v:
Transplantation. 86:143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ce4d51923443805461badc556da7ec
https://doi.org/10.1097/01.tp.0000332374.84668.6f
https://doi.org/10.1097/01.tp.0000332374.84668.6f