Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tina Yi-Ting Huang"'
Autor:
Yajing Lyu, Yongkang Yang, Varen Talwar, Haiquan Lu, Chelsey Chen, Shaima Salman, Elizabeth E. Wicks, Tina Yi-Ting Huang, Daiana Drehmer, Yufeng Wang, Qiaozhu Zuo, Emmanuel Datan, Walter Jackson, III, Dominic Dordai, Ru Wang, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113972- (2024)
Summary: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and m
Externí odkaz:
https://doaj.org/article/81c1beb3ca954c18aaff5e6ff94c9e4a
Autor:
Qiaozhu Zuo, Yongkang Yang, Yajing Lyu, Chen Yang, Chelsey Chen, Shaima Salman, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, III, Emmanuel Datan, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112164- (2023)
Summary: Intratumoral hypoxia is a microenvironmental feature that promotes breast cancer progression and is associated with cancer mortality. Plexin B3 (PLXNB3) is highly expressed in estrogen receptor-negative breast cancer, but the underlying mech
Externí odkaz:
https://doaj.org/article/33aaf8ed82ef405fa617b1722f2239c3
Autor:
Tina Yi-Ting Huang, Andrea Piunti, Jin Qi, Marc Morgan, Elizabeth Bartom, Ali Shilatifard, Amanda M. Saratsis
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase). Consequently, reduced H
Externí odkaz:
https://doaj.org/article/dcbb1c3fc7df43c0a5fd0aa7be97d7ea
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108073- (2020)
Summary: Immune checkpoint blockade (ICB) has led to therapeutic responses in some cancer patients for whom no effective treatment previously existed. ICB acts on T lymphocytes and other immune cells that are inactivated due to checkpoint signals tha
Externí odkaz:
https://doaj.org/article/ac422b58e43643a8aaeb90e0c4eba117
Autor:
Yongkang Yang, Chelsey Chen, Qiaozhu Zuo, Haiquan Lu, Shaima Salman, Yajing Lyu, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson, Emmanuel Datan, Ru Wang, Yufeng Wang, Nguyet Le, Yayun Zhu, Wenxin Qin, Gregg L. Semenza
Publikováno v:
Science Advances. 8
Hypoxia is a key characteristic of the breast cancer microenvironment that promotes expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and is associated with poor patient outcome. HIF-1 increases the expression or activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d896dcfdf36233d0f5f333c2815f74
https://doi.org/10.1126/sciadv.abo5000
https://doi.org/10.1126/sciadv.abo5000
Autor:
Juan Wang, Ye Hou, Ali Shilatifard, Xinyan Lu, Tina Yi-Ting Huang, Feng Yue, Elizabeth T. Bartom, Amanda Saratsis
Publikováno v:
Science advances. 7(23)
Pediatric high-grade gliomas (pHGGs), including glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), are morbid brain tumors. Even with treatment survival is poor, making pHGG the number one cause of cancer death in children. Up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dd2bdbd7120f9b78b72627f69dc7c9
https://pubmed.ncbi.nlm.nih.gov/34078608
https://pubmed.ncbi.nlm.nih.gov/34078608
Autor:
Ali Shilatifard, Jin Qi, Elizabeth T. Bartom, Marc A. Morgan, Tina Yi-Ting Huang, Amanda Saratsis, Andrea Piunti
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase). Consequently, reduced H3K36me3 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473b2c381d4c0cd17c6d3cf231b15d3f
https://doi.org/10.1186/s40478-020-01092-4
https://doi.org/10.1186/s40478-020-01092-4
Autor:
Juliette A. Morris, Javad Nazarian, Paul M. Thomas, Daphne Li, Amanda Saratsis, Madeline A. Zoltek, Jeannie M. Camarillo, Jin Qi, Shejuan An, Mandana Behbahani, Neil L. Kelleher, Tina Yi Ting Huang, Madhuri Kambhampati
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor. Most DIPGs harbor a histone H3 mutation, which alters histone post-translational modification (PTM) states and transcription. Here, we employed quantitativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63574e05676499083ed1e19a2cf87770
https://doi.org/10.5167/uzh-197985
https://doi.org/10.5167/uzh-197985
Autor:
Jackson III, Walter1,2, Yongkang Yang1,3, Salman, Shaima1,2, Dordai, Dominic1,2, Yajing Lyu1,2, Datan, Emmanuel1,2, Drehmer, Daiana1,2, Tina Yi-Ting Huang1,2, Yousang Hwang1,2, Semenza, Gregg L.1,2,3 gsemenza@jhmi.edu
Publikováno v:
Science Advances. 8/30/2024, Vol. 10 Issue 35, p1-12. 12p.