Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tina Y, Liu"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Type III CRISPR-Cas systems are able to target transcriptionally active DNA sequences in phages and plasmids. Here, the authors reveal the mechanism of the target nucleic acid preference of Type III-A CRISPR-Cas complexes at the transcription bubble
Externí odkaz:
https://doaj.org/article/5a2efd0e054746c6934bd0d016c53fc2
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170552 (2017)
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids. Type III-A systems use a multisubunit inter
Externí odkaz:
https://doaj.org/article/bca95d28e5344ed99d022829cc19ce02
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175612 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0170552.].
Externí odkaz:
https://doaj.org/article/68458607d61f41d68bf36968e5aa67a5
Autor:
Robin W. Klemm, Justin P. Norton, Ronald A. Cole, Chen S. Li, Seong H. Park, Matthew M. Crane, Liying Li, Diana Jin, Alexandra Boye-Doe, Tina Y. Liu, Yoko Shibata, Hang Lu, Tom A. Rapoport, Robert V. Farese, Jr., Craig Blackstone, Yi Guo, Ho Yi Mak
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1465-1475 (2013)
Lipid droplets (LDs) are the major fat storage organelles in eukaryotic cells, but how their size is regulated is unknown. Using genetic screens in C. elegans for LD morphology defects in intestinal cells, we found that mutations in atlastin, a GTPas
Externí odkaz:
https://doaj.org/article/70257a33a26343e89708a3a6891a3693
Autor:
Camille R. Simoneau, Dylan C. J. Smock, Amy Lyden, Renuka Kumar, Tina Y. Liu, Gavin J. Knott, Stephanie I Stephens, Parinaz Fozouni, Jeffrey H Shu, Sungmin Son, Melanie Ott, Jennifer A. Doudna, Daniel A. Fletcher, Daniela Boehm
SUMMARYRapid and sensitive quantification of RNA is critical for detecting infectious diseases and identifying disease biomarkers. Recent direct detection assays based on CRISPR-Cas13a1–4 avoid reverse transcription and DNA amplification required o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8271dcc9505643c01a8e0c16aeede90
https://doi.org/10.1101/2021.08.02.21261509
https://doi.org/10.1101/2021.08.02.21261509
Autor:
Chunyu Zhao, Abdul Bhuiya, Jennifer A. Doudna, Melanie Ott, Emeric J Charles, Ming X. Tan, Brittney W. Thornton, Patrick D. Hsu, Amanda Mok, Arturo M. Escajeda, María Díaz de León Derby, Katherine S. Pollard, Daniel A. Fletcher, David F. Savage, G. Renuka Kumar, Noam Prywes, Tina Y. Liu, Dylan C. J. Smock, Shineui Kim, John J Desmarais, Eli J Dugan, Parinaz Fozouni, Sungmin Son, Liana F. Lareau, Neil A. Switz, Andrew R. Harris, Stephanie I. Stephens, Maxim Armstrong, Jeffrey Shu, Shrutee Jakhanwal, Anthony T. Iavarone, Roger McIntosh, Shreeya Agrawal, Gavin J. Knott
Publikováno v:
Nat Chem Biol
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Nature Chemical Biology
medRxiv
article-version (status) pre
article-version (number) 1
Direct, amplification-free detection of RNA has the potential to transform molecular diagnostics by enabling simple on-site analysis of human or environmental samples. CRISPR-Cas nucleases offer programmable RNA-guided RNA recognition that triggers c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785d1b2d3e9f64e47f040660076a9bd
https://europepmc.org/articles/PMC10184463/
https://europepmc.org/articles/PMC10184463/
Autor:
Alison Fanton, Arturo M. Escajeda, Qi Dang, Sarah A. Stanley, Scott B. Biering, Jennifer A. Doudna, Maria Lukarska, David F. Savage, Shreeya Agrawal, Sita S. Chandrasekaran, Tina Y. Liu, Shin Kim, Dylan C. J. Smock, Gavin J. Knott, Ming X. Tan, Eli J Dugan, Eva Harris, Maxim Armstrong, María Díaz de León Derby, Patrick D. Hsu, Bérénice Charrez, Abdul Bhuiya, Daniel A. Fletcher, Noam Prywes, Andrew R. Harris, Roger McIntosh, Neil A. Switz, Sungmin Son, Amanda Mok, Erik Van Dis, Liana F. Lareau
SummaryRapid nucleic acid testing is a critical component of a robust infrastructure for increased disease surveillance. Here, we report a microfluidic platform for point-of-care, CRISPR-based molecular diagnostics. We first developed a nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e1f77d8169d1823e572832e48428314
https://doi.org/10.1101/2020.12.14.20247874
https://doi.org/10.1101/2020.12.14.20247874
Autor:
Sita S, Chandrasekaran, Shreeya, Agrawal, Alison, Fanton, Aditya R, Jangid, Bérénice, Charrez, Arturo M, Escajeda, Sungmin, Son, Roger, Mcintosh, Huyen, Tran, Abdul, Bhuiya, María Díaz, de León Derby, Neil A, Switz, Maxim, Armstrong, Andrew R, Harris, Noam, Prywes, Maria, Lukarska, Scott B, Biering, Dylan C J, Smock, Amanda, Mok, Gavin J, Knott, Qi, Dang, Erik, Van Dis, Eli, Dugan, Shin, Kim, Tina Y, Liu, Erica A, Moehle, Katherine, Kogut, Brenda, Eskenazi, Eva, Harris, Sarah A, Stanley, Liana F, Lareau, Ming X, Tan, Daniel A, Fletcher, Jennifer A, Doudna, David F, Savage, Alisha, Baldwin
Publikováno v:
Nature biomedical engineering. 6(8)
Rapid nucleic acid testing is central to infectious disease surveillance. Here, we report an assay for rapid COVID-19 testing and its implementation in a prototype microfluidic device. The assay, which we named DISCoVER (for diagnostics with coronavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00c2f7d800c01ee74ace68eaf9a0d410
https://pubmed.ncbi.nlm.nih.gov/35986182
https://pubmed.ncbi.nlm.nih.gov/35986182
Autor:
Tina Y. Liu, Jennifer A. Doudna
Publikováno v:
J Biol Chem
The Journal of biological chemistry, vol 295, iss 42
The Journal of biological chemistry, vol 295, iss 42
Among the multiple antiviral defense mechanisms found in prokaryotes, CRISPR-Cas systems stand out as the only known RNA-programmed pathways for detecting and destroying bacteriophages and plasmids. Class 1 CRISPR-Cas systems, the most widespread and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4ff050d687b5884ec7475c66bc65d9
https://pubmed.ncbi.nlm.nih.gov/32817336
https://pubmed.ncbi.nlm.nih.gov/32817336
Autor:
Amanda Mok, G. Renuka Kumar, Eli J Dugan, Noam Prywes, Stephanie I. Stephens, Shreeya Agrawal, María Díaz de León Derby, Liana F. Lareau, John J Desmarais, Brittney W. Thornton, David F. Savage, Andrew R. Harris, Katherine S. Pollard, Roger McIntosh, Patrick D. Hsu, Abdul Bhuiya, Emeric J Charles, Gavin J. Knott, Parinaz Fozouni, Anthony T. Iavarone, Melanie Ott, Shineui Kim, Sungmin Son, Ming X. Tan, Tina Y. Liu, Neil A. Switz, Chunyu Zhao, Shrutee Jakhanwal, Arturo M. Escajeda, Maxim Armstrong, Jeffrey Shu, Dylan C. J. Smock, Jennifer A. Doudna, Daniel A. Fletcher
Publikováno v:
Nature Chemical Biology. 17:1210-1210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e69823a25845fdf9d36025153b0066d
https://doi.org/10.1038/s41589-021-00882-8
https://doi.org/10.1038/s41589-021-00882-8