Matrixing Designs for Shelf-Life Determination of Parenteral Drug Product: A Comparative Analysis of Full and Reduced Stability Testing Design

Autor: Lara Pavčnik, Igor Locatelli, Tina Trdan Lušin, Robert Roškar

Publikováno v: Pharmaceutics, Vol 16, Iss 9, p 1117 (2024)

This article highlights the applicability of matrixing designs in stability studies for parenteral medications. The traditional approach involves extensive testing over the product’s shelf-life. However, matrixing designs offer an alternative appro

Externí odkaz: https://doaj.org/article/5d59e97ed6954de4b7c4448ceedf3aab

Fast and Simple LC-MS/MS Method for Rifampicin Quantification in Human Plasma

Autor: Žane Temova Rakuša, Robert Roškar, Anita Klančar Andrejc, Tina Trdan Lušin, Nataša Faganeli, Iztok Grabnar, Aleš Mrhar, Albin Kristl, Jurij Trontelj

Publikováno v: International Journal of Analytical Chemistry, Vol 2019 (2019)

A simple, fast, and cost-effective LC-MS/MS method for quantification of rifampicin in human plasma was developed and fully validated. The plasma samples containing rifampicin and isotopically labelled internal standard rifampicin D8, were cleaned up

Externí odkaz: https://doaj.org/article/1fc16eb82b664d9c940255043dc92af3

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Fast and simple LC-MS/MS method for rifampicin quantification in human plasma

Autor: Nataša Faganeli, Iztok Grabnar, Robert Roškar, Tina Trdan Lušin, Aleš Mrhar, Albin Kristl, Žane Temova Rakuša, Anita Klančar Andrejc, Jurij Trontelj

Publikováno v: International Journal of Analytical Chemistry (Online), vol. 4848236, no. 2019, pp. 1-7, 2019.
International Journal of Analytical Chemistry
International Journal of Analytical Chemistry (Online), str. 1-7 : Ilustr., Vol. 2019, 2019
COBISS-ID: 522084377
International Journal of Analytical Chemistry, Vol 2019 (2019)

A simple, fast, and cost-effective LC-MS/MS method for quantification of rifampicin in human plasma was developed and fully validated. The plasma samples containing rifampicin and isotopically labelled internal standard rifampicin D8, were cleaned up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5009789d77fe45ac4458883af5e5b97
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=141359

Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination

Autor: Uroš Urleb, Tanja Rozman Peterka, Rok Grahek, Tina Trdan Lusin, Zoran Ham, Jure Bergles

Publikováno v: Acta Pharmaceutica, Vol 69, Iss 3, Pp 363-380 (2019)
Acta Pharmaceutica
Volume 69
Issue 3

An ultra-high performance liquid chromatography method for simultaneous determination of tacrolimus impurities in pharmaceutical dosage forms has been developed. Appropriate chromatographic separation was achieved on a BEH C18 column using gradient e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715fbf278fd8b9440275ed5ab859cb82
https://doaj.org/article/54ec73a7ee72486f86dd35defad533fe