Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tina Schwabe"'
Autor:
Hua Long, Adam Simmons, Arthur Mayorga, Brady Burgess, Tuan Nguyen, Balasubrahmanyam Budda, Anna Rychkova, Herve Rhinn, Ilaria Tassi, Michael Ward, Felix Yeh, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosenthal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer’s disease (AD) and other neurodegenerative disorders. Signaling by TREM2, an innate immune receptor expressed by microg
Externí odkaz:
https://doaj.org/article/b420255d30c04ee396e2fe0de38486c6
Autor:
Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, immune regulator, and
Externí odkaz:
https://doaj.org/article/b2df0fda23a94d45afa816e976160d6e
Autor:
Mahesh Kondapuram, Benedikt Frieg, Sezin Yüksel, Tina Schwabe, Christian Sattler, Marco Lelle, Andrea Schweinitz, Ralf Schmauder, Klaus Benndorf, Holger Gohlke, Jana Kusch
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Interactions between opposite subunits of HCN channels are relevant for stabilizing the auto-inhibited state of the channel. Like cAMP-binding, K464E-mutation breaks these interactions to favor a channel’s pre-activated state.
Externí odkaz:
https://doaj.org/article/4cd43313eb1744ae8c3bd4d84f1bb5b3
Autor:
Sezin Yüksel, Michele Bonus, Tina Schwabe, Christopher Pfleger, Thomas Zimmer, Uta Enke, Inga Saß, Holger Gohlke, Klaus Benndorf, Jana Kusch
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to th
Externí odkaz:
https://doaj.org/article/9fd4821d4e2641c9a8abc668af73cd8c
Autor:
Xiaoling Li, Richard Fetter, Tina Schwabe, Christophe Jung, Liren Liu, Hermann Steller, Ulrike Gaul
Publikováno v:
eLife, Vol 10 (2021)
The blood–brain barrier (BBB) of Drosophila comprises a thin epithelial layer of subperineural glia (SPG), which ensheath the nerve cord and insulate it against the potassium-rich hemolymph by forming intercellular septate junctions (SJs). Previous
Externí odkaz:
https://doaj.org/article/1a4165662da7452f9862cb4dcd70373d
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 104962- (2020)
Recent human genetic studies have challenged long standing hypotheses about the chain of events in Alzheimer's disease (AD), as the identification of genetic risk factors in microglial genes supports a causative role for microglia in the disease. Par
Externí odkaz:
https://doaj.org/article/25f6593a3d28464881e8580af7849801
Publikováno v:
Biology Open, Vol 6, Iss 2, Pp 232-243 (2017)
During development, many epithelia are formed by a mesenchymal-epithelial transition (MET). Here, we examine the major stages and underlying mechanisms of MET during blood-brain barrier formation in Drosophila. We show that contact with the basal lam
Externí odkaz:
https://doaj.org/article/a33e65807f4641659ff5a1720b12375c
Most of receptor proteins in biomembranes are oligomers of either homologue or identical subunits, that govern a cooperative activation process. HCN ion channels, generating electric rhythmicity in specialized brain neurons and cardiomyocytes1, are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da431e9a3a7015aa47b8da6a9b6b26a
https://doi.org/10.1101/2023.04.18.537331
https://doi.org/10.1101/2023.04.18.537331
Autor:
Danilo Licastro, Melissa Manis, Bryan Bollman, Fabia Filipello, Michael E. Buckland, Laura Piccio, Carlos Cruchaga, David M. Holtzman, Kathie A. Mihindukulasuriya, Adiljan Ibrahim, Bruno A. Benitez, Francesca Cignarella, Robert Mikesell, Alberto Locca, Claudia Cantoni, Ilaria Tassi, Arnon Rosenthal, Oscar Harari, Li Deng, Tina Schwabe
Publikováno v:
Acta Neuropathologica
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8a1cc95c24ecd7fea243ab646032fc
http://europepmc.org/articles/PMC7498497
http://europepmc.org/articles/PMC7498497
Autor:
Maik Otte, Klaus Benndorf, Andrea Schweinitz, Tina Schwabe, Christian Sattler, Ralf Schmauder, Frank Schwede, Christopher Unzeitig
Publikováno v:
Journal of Neurochemistry. 154:251-262
Ionotropic purinergic receptors (P2X receptors) are non-specific cation channels that are activated by the binding of ATP at their extracellular side. P2X receptors contribute to multiple functions, including the generation of pain, inflammation, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b334b51065207d24039d4540e2405c
https://doi.org/10.1111/jnc.14948
https://doi.org/10.1111/jnc.14948