Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Tina S. Skinner-Adams"'
Autor:
Christopher JS. Hart, Andrew G. Riches, Snigdha Tiash, Rebecca Abraham, Keely Fayd’Herbe, Ellis Joch, Bilal Zulfiqar, Melissa L. Sykes, Vicky M. Avery, Jan Šlapeta, Sam Abraham, John H. Ryan, Tina S. Skinner-Adams
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 54-62 (2023)
Giardia duodenalis is the causative agent of the neglected diarrhoeal disease giardiasis. While often self-limiting, giardiasis is ubiquitous and impacts hundreds of millions of people annually. It is also a common gastro-intestinal disease of domest
Externí odkaz:
https://doaj.org/article/3fa7736589924458957c5c2cc3f0b335
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 249-256 (2020)
The prevention and treatment of malaria requires a multi-pronged approach, including the development of drugs that have novel modes of action. Histone deacetylases (HDACs), enzymes involved in post-translational protein modification, are potential ne
Externí odkaz:
https://doaj.org/article/c65cbe77f8f5495ba8bbb913ad120199
Autor:
Snigdha Tiash, Jake Saunders, Christopher J.S. Hart, John H. Ryan, Andrew G. Riches, Tina S. Skinner-Adams
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 12, Iss , Pp 60-67 (2020)
Giardia duodenalis, the most prevalent human intestinal parasite causes the disease, giardiasis. On an annual basis G. duodenalis infects ~1 billion people, of which ~280 million develop symptomatic disease. Giardiasis can be severe and chronic, caus
Externí odkaz:
https://doaj.org/article/869d3b2bd0794b4aab21dcde3b91fc96
Autor:
Christopher J. S. Hart, Andrew G. Riches, Snigdha Tiash, Erin Clapper, Soumya Ramu, Johannes Zuegg, John H. Ryan, Tina S. Skinner-Adams
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3182 (2022)
On an annual basis the flagellate protozoan, Giardia duodenalis, is responsible for an estimated one billion human infections of which approximately two hundred million cause disease. However, the treatment of Giardia infections is reliant on a small
Externí odkaz:
https://doaj.org/article/4f6dd0a1bdf549999d1439e7cc7483e9
The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides
Autor:
Gillian M. Fisher, Simon A. Cobbold, Andrew Jezewski, Emma F. Carpenter, Megan Arnold, Annie N. Cowell, Erick T. Tjhin, Kevin J. Saliba, Tina S. Skinner-Adams, Marcus C. S. Lee, Audrey Odom John, Elizabeth A. Winzeler, Malcolm J. McConville, Sally-Ann Poulsen, Katherine T. Andrews
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic
Externí odkaz:
https://doaj.org/article/610827e8ff5a4ac08e02462e0f5e26af
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 189-193 (2018)
Bromodomain-containing proteins (BDPs) are involved in the regulation of eukaryotic gene expression. Compounds that bind and/or inhibit BDPs are of interest as tools to better understand epigenetic regulation, and as possible drug leads for different
Externí odkaz:
https://doaj.org/article/9e3ba0dab96549508ca108c49cf6c4ed
Autor:
Christopher J.S. Hart, Taylah Munro, Katherine T. Andrews, John H. Ryan, Andrew G. Riches, Tina S. Skinner-Adams
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 1, Pp 83-89 (2017)
Giardia duodenalis is an intestinal parasite that causes giardiasis, a widespread human gastrointestinal disease. Treatment of giardiasis relies on a small arsenal of compounds that can suffer from limitations including side-effects, variable treatme
Externí odkaz:
https://doaj.org/article/b6a88d5961814ec080e145a59d05eb41
Autor:
Ming Jang Chua, Megan S.J. Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F. Späth, Eric Prina, Raymond J. Pierce, David P. Fairlie, Tina S. Skinner-Adams, Katherine T. Andrews
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 1, Pp 42-50 (2017)
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progres
Externí odkaz:
https://doaj.org/article/652ca88e8de1425aa193abfb8a20b233
Autor:
Brett D. Schwartz, Mark J. Coster, Tina S. Skinner-Adams, Katherine T. Andrews, Jonathan M. White, Rohan A. Davis
Publikováno v:
Marine Drugs, Vol 13, Iss 9, Pp 5784-5795 (2015)
Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequentl
Externí odkaz:
https://doaj.org/article/623c45ec2ba348dcb643745991d2732a
Autor:
Karine Thivierge, Rency T. Mathew, Desire M. M. Nsangou, Fabio Da Silva, Sophie Cotton, Tina S. Skinner-Adams, Katharine R. Trenholme, Christopher L. Brown, Colin M. Stack, Donald L. Gardiner, John P. Dalton
Publikováno v:
ARKIVOC, Vol 2012, Iss 4, Pp 330-346 (2012)
Externí odkaz:
https://doaj.org/article/3d531d6849984330a80c2835c0d9cffb