The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling.

Autor: Roberto Gherzi, Michele Trabucchi, Marco Ponassi, Tina Ruggiero, Giorgio Corte, Christoph Moroni, Ching-Yi Chen, Khalid S Khabar, Jens S Andersen, Paola Briata

Publikováno v: PLoS Biology, Vol 5, Iss 1, p e5 (2006)

Beta-catenin plays an essential role in several biological events including cell fate determination, cell proliferation, and transformation. Here we report that beta-catenin is encoded by a labile transcript whose half-life is prolonged by Wnt and ph

Externí odkaz: https://doaj.org/article/d4c5b6a4f9264eff8c800c05fbe91ca5

Frequent NS5A and multiclass resistance in almost all HCV genotypes at DAA failures: What are the chances for second-line regimens?

Autor: Velia Chiara Di Maio, Valeria Cento, Marianna Aragri, Stefania Paolucci, Teresa Pollicino, Nicola Coppola, Bianca Bruzzone, Valeria Ghisetti, Maurizio Zazzi, Maurizia Brunetto, Ada Bertoli, Silvia Barbaliscia, Silvia Galli, William Gennari, Fausto Baldanti, Giovanni Raimondo, Carlo Federico Perno, Francesca Ceccherini-Silberstein, Pietro Andreone, Massimo Andreoni, Mario Angelico, Sergio Babudieri, Giorgio Barbarini, Vincenzo Boccaccio, Lucio Boglione, Matteo Bolis, Stefano Bonora, Vanni Borghi, Giuseppina Brancaccio, Savino Bruno, Pierluigi Cacciatore, Vincenza Calvaruso, Nicola Caporaso, Antonio Ciaccio, Alessia Ciancio, Piero Colombatto, Raffaele Cozzolongo, Antonio Craxì, Cecilia D'Ambrosio, Gabriella D'Ettorre, Andrea De Luca, Antonio Di Biagio, Giovanni Di Perri, Simona Francioso, Giovanni Battista Gaeta, Alessia Giorgini, Antonio Grieco, Guido Gubertini, Roberto Gulminetti, Lara Lambiase, Ilaria Lenci, Miriam Lichtner, Ivana Maida, Simona Marenco, Letizia Marinaro, Renato Maserati, Chiara Masetti, Michela Melis, Elisa Meregalli, Valeria Micheli, Filomena Morisco, Fosca Niero, Laura Ambra Nicolini, Valeria Pace Palitti, Maurizio Paoloni, Giustino Parruti, Caterina Pasquazzi, Adriano Pellicelli, Ennio Polilli, Maria Laura Ponti, Massimo Puoti, Maria Rendina, Giuliano Rizzardini, Barbara Rossetti, Tina Ruggiero, Vincenzo Sangiovanni, Mario Starace, Laura Sticchi, Pierluigi Tarquini, Pierluigi Toniutto, Vincenzo Vullo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5feb34a815fb252bfeeb7d412c134bae
http://hdl.handle.net/11573/1552372

LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages

Autor: Simona Zupo, Tina Ruggiero, Brian D. Harfe, Roberto Gherzi, Michael T. McManus, Michele Trabucchi, M. Geoff Rosenfeld, Francesca De Santa, Paola Briata

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(9)

The importance of post-transcriptional mechanisms for the regulation of the homoeostasis of the immune system and the response to challenge by microorganisms is becoming increasingly appreciated. We investigated the contribution of microRNAs (miRNAs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc92240c451f834dc52a381906efdad
https://pubmed.ncbi.nlm.nih.gov/19423639

Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin

Autor: Maria Flavia Di Renzo, Stefania Crispi, Andrea Rasola, Silvia Saviozzi, Martina Olivero, Ferdinando Di Cunto, Raffaele A. Calogero, Tina Ruggiero, Nadia Coltella

Publikováno v: Molecular cancer therapeutics 5 (2006): 1126–1135.
info:cnr-pdr/source/autori:Olivero M, Ruggiero T, Saviozzi S, Rasola A, Coltella N, Crispi S, Di Cunto F, Calogero R, Di Renzo MF./titolo:Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin./doi:/rivista:Molecular cancer therapeutics/anno:2006/pagina_da:1126/pagina_a:1135/intervallo_pagine:1126–1135/volume:5

Advanced ovarian cancers are initially responsive to chemotherapy with platinum drugs but develop drug resistance in most cases. We showed recently that hepatocyte growth factor (HGF) enhances death of human ovarian cancer cell lines treated with cis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2510c97cb2d3d38d1f03763ee8ae604a
http://hdl.handle.net/2318/29289

The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling

Autor: Marco Ponassi, Tina Ruggiero, Paola Briata, Michele Trabucchi, Roberto Gherzi, Khalid S.A. Khabar, Giorgio Corte, Christoph Moroni, Ching Yi Chen, Jens S. Andersen

Publikováno v: PLoS Biology
PLoS Biology, Vol 5, Iss 1, p e5 (2006)
Gherzi, R, Trabucchi, M, Ponassi, M, Ruggiero, T, Corte, G, Moroni, C, Chen, C-Y, Khabar, K S, Andersen, J S & Briata, P 2006, ' The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling ', PLoS-Biology, vol. 5, no. 1, pp. 82-95 . https://doi.org/10.1371/journal.pbio.0050005

β-catenin plays an essential role in several biological events including cell fate determination, cell proliferation, and transformation. Here we report that β-catenin is encoded by a labile transcript whose half-life is prolonged by Wnt and phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b87701b60133f1f05de319f3b0efaa
https://doi.org/10.1371/journal.pbio.0050005