Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Tina Rich"'
Autor:
Tina Rich, Archana Varadaraj
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1014 (2007)
Intranuclear inclusion bodies (IBs) are the histopathologic markers of multiple protein folding diseases. IB formation has been extensively studied using fluorescent fusion products of pathogenic polyglutamine (polyQ) expressing proteins. These studi
Externí odkaz:
https://doaj.org/article/0b685e96490f47fe8fdc3b9750bf5733
Autor:
Stephen J Kennel, Joseph W Jackson, Alan Stuckey, Tina Richey, James S Foster, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301756 (2024)
IntroductionAmyloid deposition is a cause of restrictive cardiomyopathy. Patients who present with cardiac disease can be evaluated for transthyretin (TTR)-associated cardiac amyloidosis using nuclear imaging with 99mTc-labeled pyrophosphate (PYP); h
Externí odkaz:
https://doaj.org/article/ae00333921e540a68f07fb68eada90da
Autor:
James S. Foster, Manasi Balachandran, Trevor J. Hancock, Emily B. Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D. Williams, Joseph W. Jackson, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSystemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral organs and tissues. Amyloid accumulation causes organ dysfunction and is not generally clea
Externí odkaz:
https://doaj.org/article/3ce636148a204e3aafd0f0efaec0fd54
Autor:
Tina Rich, Janet C. Patterson-Kane
Publikováno v:
ILAR Journal. 55:86-99
Superficial digital flexor tendon (SDFT) injury in equine athletes is one of the most well-accepted, scientifically supported companion animal models of human disease (i.e., exercise-induced Achilles tendon [AT] injury). The SDFT and AT are functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a3968d6df217bbbc630f2392ec69a1
https://doi.org/10.1093/ilar/ilu004
https://doi.org/10.1093/ilar/ilu004
Publikováno v:
Cell Cycle. 8:2711-2717
The tumor suppressor promyelocytic leukemia protein (PML) is possibly unique in that its tumor suppressive functions may be attributed to both the protein and the conspicuous nuclear bodies (PML-NBs) that PML builds. Untangling the role of either the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd18be7b67a4f613ae2c4c21907777
https://doi.org/10.4161/cc.8.17.9462
https://doi.org/10.4161/cc.8.17.9462
Publikováno v:
Journal of General Virology. 90:95-104
Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de273061213d3117fb7e1ca59e2cb710
https://doi.org/10.1099/vir.0.005512-0
https://doi.org/10.1099/vir.0.005512-0
Publikováno v:
Molecular Immunology. 45:1477-1484
The promyelocytic leukaemia (PML) nuclear domain (PML-ND) is a nuclear sentinel for stress. Each PML-ND cradles a delicate scaffold of nucleoproteins, many of which can trigger the apoptotic death cascade if disrupted. Given their place in integratin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dce38f20151f1db492c6fa1460a43a6
https://doi.org/10.1016/j.molimm.2007.08.019
https://doi.org/10.1016/j.molimm.2007.08.019
Autor:
Hamish S. Scott, Ana Rebane, Simona W. Rossi, Clare E. Alexander, Brian J. Ferguson, Pärt Peterson, Joyce Wong, Eric J. Jenkinson, Ingrid Liiv, Catherine L. Worth, Anne Cooke, Martti Laan, Graham Anderson, Tina Rich
Publikováno v:
Journal of Biological Chemistry. 283:1723-1731
Developing T cells encounter peripheral self-antigens in the thymus in order to delete autoreactive clones. It is now known that the autoimmune regulator protein (AIRE), which is expressed in thymic medullary epithelial cells, plays a key role in reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4db5423183a57026c317347e944af8
https://doi.org/10.1074/jbc.m707211200
https://doi.org/10.1074/jbc.m707211200
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Rationale Prognostic accuracy of the quick sequential organ failure assessment (qSOFA) and CRB-65 (confusion, respiratory rate, blood pressure and age (≥65 years)) risk scores have not been widely evaluated in patients with SARS-CoV-2-positive comp
Externí odkaz:
https://doaj.org/article/2fbb87adacb34218a401d15b03868e73
Autor:
CL Dovey, Archana Varadaraj, Brian J. Ferguson, Andrew H. Wyllie, L.N. Laredj, Clare E. Alexander, N Lubben, Tina Rich
Publikováno v:
The Journal of Pathology. 211:471-480
Promyelocytic leukaemia nuclear domains (PML-NDs) comprise a shell of PML protein and many labile cargo proteins. The nature of their cargo, their juxtaposition to foci of damaged DNA following ionizing radiation (IR), and the altered DNA damage resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfca6e216f88ed3e31601e3d8316a89
https://doi.org/10.1002/path.2126
https://doi.org/10.1002/path.2126