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Akademický článek

Impavido attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice

Autor: C. Alicia Traughber, Amanda J. Iacano, Kalash Neupane, Mariam R. Khan, Emmanuel Opoku, Tina Nunn, Ashutosh Prince, Naseer Sangwan, Stanley L. Hazen, Jonathan D. Smith, Kailash Gulshan

Publikováno v: iScience, Vol 26, Iss 4, Pp 106453- (2023)

Summary: Impavido (Miltefosine) is an FDA-approved drug for treating leishmaniasis and primary amebic meningoencephalitis. We have shown previously that Miltefosine increased cholesterol release and dampened Nlrp3 inflammasome assembly in macrophages

Externí odkaz: https://doaj.org/article/99e28f8c7c7a4508851f6ba00250eb94

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Miltefosine attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice

Autor: C. Alicia Traughber, Amanda J Iacano, Mariam R Khan, Kalash Neupane, Emmanuel Opoku, Tina Nunn, Naseer Sangwan, Stanley L Hazen, Jonathan D Smith, Kailash Gulshan

Excess cholesterol induces foam cell formation, NLRP3 inflammasome activation, and IL-1β release in atherosclerotic plaques. We have shown previously that Miltefosine increased cholesterol release and dampened NLRP3 inflammasome assembly in macropha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbe8bc967a5f7dca1651d52fc0bd796a
https://doi.org/10.1101/2022.08.22.504848

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Barrier Housing and Gender Effects on Allergic Airway Disease in a Murine House Dust Mite Model

Autor: Kimberly Queisser, Kewal Asosingh, Serpil C. Erzurum, Timothy Myshrall, Matthew Frimel, Nicholas Wanner, Naseer Sangwan, Kelly Weiss, Tina Nunn

Publikováno v: ImmunoHorizons. 5:33-47

Allergic airway disease models use laboratory mice housed in highly controlled and hygienic environments, which provide a barrier between the mice and a predetermined list of specific pathogens excluded from the facility. In this study, we hypothesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f9a1b15fa5d8058a85e39390c72142
https://doi.org/10.4049/immunohorizons.2000096

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