Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tina M. Schnoeder"'
Autor:
Nuria Tubío-Santamaría, Ashok Kumar Jayavelu, Tina M. Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V. Wenge, Fynn M. Hansen, Joanna M. Kirkpatrick, Nidhi Jyotsana, Steven W. Lane, Björn von Eyss, Aniruddha J. Deshpande, Michael W. M. Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frédéric Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A. Armstrong, Florian H. Heidel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for thera
Externí odkaz:
https://doaj.org/article/32a44bd3490c43d78d23fc64b13aaac5
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
While Janus-kinase (JAK)-inhibitors effectively reduce the inflammatory phenotype of myeloproliferative neoplasms (MPN), they do not affect disease burden or presence of the mutated clone to a major extent. Here, we show how Janus-kinase 2 (JAK2)-mut
Externí odkaz:
https://doaj.org/article/456df2cfe6ca47dab91567fd6162afef
Autor:
Muhammed Burak Demircan, Peter C. Mgbecheta, Anne Kresinsky, Tina M. Schnoeder, Katrin Schröder, Florian H. Heidel, Frank D. Böhmer
Publikováno v:
Antioxidants, Vol 11, Iss 3, p 513 (2022)
Acute myeloid leukemia (AML) cells harbor elevated levels of reactive oxygen species (ROS), which promote cell proliferation and cause oxidative stress. Therefore, the inhibition of ROS formation or elevation beyond a toxic level have been considered
Externí odkaz:
https://doaj.org/article/76f0fad3945d48f7882ce02f3570f99d
Autor:
Jasmin Straube, Theresa Eifert, Therese Vu, Yashaswini Janardhanan, Rohit Haldar, Björn von Eyss, Leanne Cooper, Claudia Bruedigam, Victoria Y. Ling, Emily Cooper, Ann-Marie Patch, Lars Bullinger, Tina M. Schnoeder, Megan Bywater, Florian H. Heidel, Steven W. Lane
Publikováno v:
Leukemia. 37:741-750
Murine models offer a valuable tool to recapitulate genetically defined subtypes of AML, and to assess the potential of compound mutations and clonal evolution during disease progression. This is of particular importance for difficult to treat leukem
Autor:
Florian Perner, Peter R. Mertens, Andreas Hochhaus, Scott A. Armstrong, Charlie Hatton, Sabine Brandt, Ciara Murphy, Matthias Mann, Nicolas Schröder, Ashok Kumar Jayavelu, Birgit Perner, Tina M. Schnoeder, Yijun Xiong, Anna Mandinova, Kristina Todorova, Jessica I. Hoell, Theresa Eifert, Nicolas Huber, Nomusa Mashamba, Florian H. Heidel, Nuria Tubio Santamaria, Maximilian Hartmann
Publikováno v:
Leukemia
Persistence of malignant clones is a major determinant of adverse outcome in patients with hematologic malignancies. Despite the fact that the majority of patients with acute myeloid leukemia (AML) achieve complete remission after chemotherapy, a lar
Autor:
Tina M Schnoeder, Florian Perner, Ashok Kumar Jayavelu, Lianghao Mao, Qirui Zhang, Chen-Jen Hsu, Theresa Eifert, Uwe Grunwald, Peter Mertens, Dhanir Tailor, Akram Taherinasab, Theodore P. Braun, Sanjay Malhotra, Florian H. Heidel
Publikováno v:
Blood. 140:491-492
Autor:
Böhmer, Muhammed Burak Demircan, Peter C. Mgbecheta, Anne Kresinsky, Tina M. Schnoeder, Katrin Schröder, Florian H. Heidel, Frank D.
Publikováno v:
Antioxidants; Volume 11; Issue 3; Pages: 513
Acute myeloid leukemia (AML) cells harbor elevated levels of reactive oxygen species (ROS), which promote cell proliferation and cause oxidative stress. Therefore, the inhibition of ROS formation or elevation beyond a toxic level have been considered
Autor:
Steven W. Lane, Florian Perner, Nicolas Huber, Florian H. Heidel, Elizabeth Ng, Andreas Hochhaus, Edouard G. Stanley, Zhu Chen, Chen-Jen Hsu, Monica Nafria, Ashok Kumar Jayavelu, Lars Bullinger, Lu Jiang, Klaus-Dieter Fischer, Constanze Bonifer, Matthias Mann, Marcus Buschbeck, Steffen Brodt, Holger Bierhoff, Tina M. Schnoeder, Adrian Schwarzer, Sai-Juan Chen, Joanna Kirkpatrick, Georg Matziolis, Olaf Heidenreich, Patricia Arreba-Tutusaus, Theresa Eifert, Björn von Eyss, Chun-Wei Chen, Konstanze Döhner, Andrew G. Elefanty, Anna Dolnik, Yuting Dai, Sophie G Kellaway, Anetta Ptasinska, Salam A. Assi, Alessandro Ori
Publikováno v:
Blood
In an effort to identify novel drugs targeting fusion-oncogene–induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, we uncovered a deregulation of phospholipase C (PLC) signaling. We id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc5d880ca55311258241635b370c0f4
http://edoc.mdc-berlin.de/21022/1/21022oa.pdf
http://edoc.mdc-berlin.de/21022/1/21022oa.pdf
Autor:
Muhammed Burak Demircan, Tina M. Schnoeder, Peter C. Mgbecheta, Katrin Schröder, Frank-D. Böhmer, Florian H. Heidel
Publikováno v:
Journal of cancer research and clinical oncology, Early view
Purpose Oxidative stress has been linked to initiation and progression of cancer and recent studies have indicated a potential translational role regarding modulation of ROS in various cancers, including acute myeloid leukemia (AML). Detailed underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bdf4d686c1fa56ff5939e8eb9a4f3e
https://repository.publisso.de/resource/frl:6432780
https://repository.publisso.de/resource/frl:6432780
Autor:
Tina M Schnoeder, Daniela S. Krause, Lars Bullinger, Denise Wolleschak, Björn Hartleben, Costanza Zanetti, Tobias B. Huber, Sönke Weinert, Nuria Tubío Santamaría, Sonika Godavarthy, Banaja P. Dash, Juliane Mohr, Florian H. Heidel, Michael Naumann, Carolin Herzog, Thilo Kähne
Publikováno v:
Leukemia. 32:1211-1221
Cell fate determinants influence self-renewal potential of hematopoietic stem cells. Scribble and Llgl1 belong to the Scribble polarity complex and reveal tumor-suppressor function in drosophila. In hematopoietic cells, genetic inactivation of Llgl1