Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tina M. Schnöder"'
Autor:
Sibylle Cocciardi, Anna Dolnik, Silke Kapp-Schwoerer, Frank G. Rücker, Susanne Lux, Tamara J. Blätte, Sabrina Skambraks, Jan Krönke, Florian H. Heidel, Tina M. Schnöder, Andrea Corbacioglu, Verena I. Gaidzik, Peter Paschka, Veronica Teleanu, Gudrun Göhring, Felicitas Thol, Michael Heuser, Arnold Ganser, Daniela Weber, Eric Sträng, Hans A. Kestler, Hartmut Döhner, Lars Bullinger, Konstanze Döhner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
NPM1 gene mutation is a founding event in acute myeloid leukaemia. Here, the authors find that at relapse, some patients lose the NPM1 mutation and show distinct mutational and gene expression patterns, highlighting a potential route for relapse.
Externí odkaz:
https://doaj.org/article/ab42b55dd8f048919990526549391171
Autor:
Satish Ranjan, Alexander Goihl, Shrey Kohli, Ihsan Gadi, Mandy Pierau, Khurrum Shahzad, Dheerendra Gupta, Fabian Bock, Hongjie Wang, Haroon Shaikh, Thilo Kähne, Dirk Reinhold, Ute Bank, Ana C. Zenclussen, Jana Niemz, Tina M. Schnöder, Monika Brunner-Weinzierl, Thomas Fischer, Thomas Kalinski, Burkhart Schraven, Thomas Luft, Jochen Huehn, Michael Naumann, Florian H. Heidel, Berend Isermann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the d
Externí odkaz:
https://doaj.org/article/17c58ccb118041e9a3a369a75450a669
Autor:
Anne Kresinsky, Reinhard Bauer, Tina M. Schnöder, Tobias Berg, Daria Meyer, Volker Ast, Rainer König, Hubert Serve, Florian H. Heidel, Frank-D. Böhmer, Jörg P. Müller
Publikováno v:
Haematologica, Vol 103, Iss 11 (2018)
Externí odkaz:
https://doaj.org/article/f006f8ad8d8f408f877180ee73f1e904
Autor:
Caroline Ebert, Florian Perner, Denise Wolleschak, Tina M. Schnöder, Thomas Fischer, Florian H. Heidel
Publikováno v:
Haematologica, Vol 101, Iss 3 (2016)
Externí odkaz:
https://doaj.org/article/bdb25c9bf31c4bb3bca911f4cf027a6f
Autor:
Denise Wolleschak, Thomas S. Mack, Florian Perner, Stephanie Frey, Tina M. Schnöder, Marie-Christine Wagner, Christine Höding, Marina C. Pils, Andreas Parkner, Stefanie Kliche, Burkhart Schraven, Katrin Hebel, Monika Brunner-Weinzierl, Satish Ranjan, Berend Isermann, Daniel B. Lipka, Thomas Fischer, Florian H. Heidel
Publikováno v:
Haematologica, Vol 99, Iss 6 (2014)
Externí odkaz:
https://doaj.org/article/68fbacd4bf9642a2b43031de231f561e
Autor:
Philipp Ernst, Tina M. Schnöder, Nicolas Huber, Florian Perner, Ashok Kumar Jayavelu, Theresa Eifert, Chen-Jen Hsu, Nuria Tubío-Santamaría, Carl C. Crodel, Martin Ungelenk, Christian A. Hübner, Joachim H. Clement, Andreas Hochhaus, Florian H. Heidel
Publikováno v:
Leukemia. 36:1843-1849
Mutations of the JAK2 gene are frequent aberrations in the aging hematopoietic system and in myeloid neoplasms. While JAK-inhibitors efficiently reduce hyperinflammation induced by the constitutively active mutated JAK2 kinase, the malignant clone an
Autor:
Bärbel Edelmann-Stephan, Andreas Hochhaus, Sabine Brandt, Nicolas Schröder, Florian Perner, Gurumoorthy Krishnamoorthy, Iain Coldham, Amit U. Sinha, Claudia Waskow, Lars Bullinger, Stefanie Jilg, Philipp J. Jost, Martin Ungelenk, Francesca Palandri, Matthias Mann, Rebecca Austin, Frank Edlich, Tina M. Schnöder, Susann Rahmig, Carolin Herzog, Robert Zeiser, Steven W. Lane, Arno Meiler, Thomas Ernst, Christian A. Hübner, Juliane Mohr, Ashok Kumar Jayavelu, Peter R. Mertens, Nicolas Huber, Florian H. Heidel, Ann Mullally, Berend Isermann
Publikováno v:
Nature
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively
Autor:
Tina M. Schnöder, Stefan Freigang, Georgia Konstantinidou, Ralph A. Schmid, Sabina Berezowska, Alessandro Rimessi, Paolo Pinton, Johanna Baumgartner, Chiara Pozzato, Florian H. Heidel, Maria Saliakoura, Matteo Rossi Sebastiano, Lukas Bubendorf, Spasenija Savic Prince
Publikováno v:
Nature cell biology
Mutant KRAS modulates the metabolic plasticity of cancer cells to confer a growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutan
Autor:
Eric Sträng, Andrea Corbacioglu, Sabrina Skambraks, Silke Kapp-Schwoerer, Sibylle Cocciardi, Veronica Teleanu, Anna Dolnik, Verena I. Gaidzik, Susanne Lux, Peter Paschka, Michael Heuser, Jan Krönke, Hartmut Döhner, Florian H. Heidel, Tina M. Schnöder, Felicitas Thol, Arnold Ganser, Konstanze Döhner, Gudrun Göhring, Tamara J. Blätte, Hans A. Kestler, Frank G. Rücker, Daniela Weber, Lars Bullinger
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Mutations in the nucleophosmin 1 (NPM1) gene are considered founder mutations in the pathogenesis of acute myeloid leukemia (AML). To characterize the genetic composition of NPM1 mutated (NPM1mut) AML, we assess mutation status of five recurrently mu
Autor:
Jörg P. Müller, Carl-Magnus Svensson, Rainer König, Tina M. Schnöder, Martina Rauner, Lorenz C. Hofbauer, Volker Ast, Ingrid Hilger, Marc Thilo Figge, Frank-D. Böhmer, Florian H. Heidel, Ilse D. Jacobsen, Bianca Hoffmann, Anne Kresinsky
Publikováno v:
Oncogene. 38:4773-4787
The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Activating mutations in FLT3 occur in 25-30% of acute myeloid leukaemia (AML) patients. Most common are internal tandem duplications of sequence (ITD) leading to