Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tina Loeffler"'
Autor:
Livia Breznik, Magdalena Daurer, Roland Rabl, Tina Loeffler, Estibaliz Etxeberria-Rekalde, Joerg Neddens, Stefanie Flunkert, Manuela Prokesch
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundParkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons and the accumulation of α-synuclein (α-syn) aggregates. The A53T missense point mutation occurs in autos
Externí odkaz:
https://doaj.org/article/7b4a2cab111043688b5e5efe3b8aac70
Autor:
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Panzenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101972- (2024)
Externí odkaz:
https://doaj.org/article/d463c6ae0e50498bb0f6926bfae42908
Autor:
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Pazenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101959- (2024)
Objectives: Aggregation and misfolding of amyloid beta (Aβ) and tau proteins, suggested to arise from post-translational modification processes, are thought to be the main cause of Alzheimer's disease (AD). Additionally, a plethora of evidence exist
Externí odkaz:
https://doaj.org/article/adc5cdc60dae4aeea2d8de4c6bfa0ca8
Autor:
Joerg Neddens, Magdalena Daurer, Tina Loeffler, Saioa Alzola Aldamizetxebarria, Stefanie Flunkert, Birgit Hutter-Paier
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Excessive tau phosphorylation is the hallmark of tauopathies. Today’s research thus focusses on the development of drugs targeting this pathological feature. To test new drugs in preclinical studies, animal models are needed that properly mimic thi
Externí odkaz:
https://doaj.org/article/df5722407bdb4230818fc8a4c7743ad7
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Neurofilament-light chain (NF-L) is a well-known clinical biomarker of many neurodegenerative diseases. By analyzing amyotrophic lateral sclerosis (ALS) patients cerebrospinal fluid (CSF) or plasma, progression of NF-L levels can forecast conversion
Externí odkaz:
https://doaj.org/article/0d5bf9bfac8a4832a8bd8c30d7a1d5d2
Autor:
Victoria Schiffer, Estibaliz Santiago-Mujika, Stefanie Flunkert, Staffan Schmidt, Martina Farcher, Tina Loeffler, Irene Schilcher, Maria Posch, Joerg Neddens, Ying Sun, Jan Kehr, Birgit Hutter-Paier
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227077 (2020)
Gaucher disease is caused by a deficiency in glucocerebrosidase that can result in non-neuronal as well as neuronal symptoms. Common visceral symptoms are an increased organ size, specifically of the spleen, and glucosylceramide as well as glucosylsp
Externí odkaz:
https://doaj.org/article/934465be4e504e42abf8e2944f2bd11d
Autor:
Joerg Neddens, Magdalena Daurer, Stefanie Flunkert, Kerstin Beutl, Tina Loeffler, Lauren Walker, Johannes Attems, Birgit Hutter-Paier
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235543 (2020)
Senile plaques frequently contain Aβ-pE(3), a N-terminally truncated Aβ species that is more closely linked to AD compared to other Aβ species. Tau protein is highly phosphorylated at several residues in AD, and specifically phosphorylation at Ser
Externí odkaz:
https://doaj.org/article/cf26ea1d390049a8b12b75c147266aa2
Autor:
Joerg Neddens, Magdalena Temmel, Stefanie Flunkert, Bianca Kerschbaumer, Christina Hoeller, Tina Loeffler, Vera Niederkofler, Guenther Daum, Johannes Attems, Birgit Hutter-Paier
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Alzheimer’s disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions. Tau phosphorylation causes formation of neurofibrillary tangles and neuropil threads. Phosphorylation at tau Ser2
Externí odkaz:
https://doaj.org/article/5e739ae9d8044eee9e537a57254e5932
Autor:
Estibaliz Santiago-Mujica, Stefanie Flunkert, Roland Rabl, Joerg Neddens, Tina Loeffler, Birgit Hutter-Paier
Publikováno v:
Heliyon, Vol 5, Iss 3, Pp e01293- (2019)
Niemann-Pick type C disease (NPC) is a fatal autosomal recessive disorder characterized by a defect in the intracellular transport of lipoproteins leading to the accumulation of lipids in diverse tissues. A visceral and neuronal phenotype mimicking h
Externí odkaz:
https://doaj.org/article/fb3ad7c087c74498bf11829d5c6ef972
Autor:
Vijay R. Varma, Rishi J. Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B. Horton, Seoyoung C. Kim, Tobias Gerhard, Jodi B. Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty
Publikováno v:
Molecular Psychiatry. 28:1312-1326
We recently nominated cytokine signaling through the Janus-kinase–signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothe